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Cancer: A turbulence problem()
Cancers are complex, adaptive ecosystems. They remain the leading cause of disease-related death among children in North America. As we approach computational oncology and Deep Learning Healthcare, our mathematical models of cancer dynamics must be revised. Recent findings support the perspective th...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Neoplasia Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7588841/ https://www.ncbi.nlm.nih.gov/pubmed/33142240 http://dx.doi.org/10.1016/j.neo.2020.09.008 |
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author | Uthamacumaran, Abicumaran |
author_facet | Uthamacumaran, Abicumaran |
author_sort | Uthamacumaran, Abicumaran |
collection | PubMed |
description | Cancers are complex, adaptive ecosystems. They remain the leading cause of disease-related death among children in North America. As we approach computational oncology and Deep Learning Healthcare, our mathematical models of cancer dynamics must be revised. Recent findings support the perspective that cancer-microenvironment interactions may consist of chaotic gene expressions and turbulent protein flows during pattern formation. As such, cancer pattern formation, protein-folding and metastatic invasion are discussed herein as processes driven by chemical turbulence within the framework of complex systems theory. To conclude, cancer stem cells are presented as strange attractors of the Waddington landscape. |
format | Online Article Text |
id | pubmed-7588841 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Neoplasia Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-75888412020-11-05 Cancer: A turbulence problem() Uthamacumaran, Abicumaran Neoplasia Review article Cancers are complex, adaptive ecosystems. They remain the leading cause of disease-related death among children in North America. As we approach computational oncology and Deep Learning Healthcare, our mathematical models of cancer dynamics must be revised. Recent findings support the perspective that cancer-microenvironment interactions may consist of chaotic gene expressions and turbulent protein flows during pattern formation. As such, cancer pattern formation, protein-folding and metastatic invasion are discussed herein as processes driven by chemical turbulence within the framework of complex systems theory. To conclude, cancer stem cells are presented as strange attractors of the Waddington landscape. Neoplasia Press 2020-10-24 /pmc/articles/PMC7588841/ /pubmed/33142240 http://dx.doi.org/10.1016/j.neo.2020.09.008 Text en © 2020 Published by Elsevier Inc. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review article Uthamacumaran, Abicumaran Cancer: A turbulence problem() |
title | Cancer: A turbulence problem() |
title_full | Cancer: A turbulence problem() |
title_fullStr | Cancer: A turbulence problem() |
title_full_unstemmed | Cancer: A turbulence problem() |
title_short | Cancer: A turbulence problem() |
title_sort | cancer: a turbulence problem() |
topic | Review article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7588841/ https://www.ncbi.nlm.nih.gov/pubmed/33142240 http://dx.doi.org/10.1016/j.neo.2020.09.008 |
work_keys_str_mv | AT uthamacumaranabicumaran canceraturbulenceproblem |