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Cancer: A turbulence problem()

Cancers are complex, adaptive ecosystems. They remain the leading cause of disease-related death among children in North America. As we approach computational oncology and Deep Learning Healthcare, our mathematical models of cancer dynamics must be revised. Recent findings support the perspective th...

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Detalles Bibliográficos
Autor principal: Uthamacumaran, Abicumaran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7588841/
https://www.ncbi.nlm.nih.gov/pubmed/33142240
http://dx.doi.org/10.1016/j.neo.2020.09.008
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author Uthamacumaran, Abicumaran
author_facet Uthamacumaran, Abicumaran
author_sort Uthamacumaran, Abicumaran
collection PubMed
description Cancers are complex, adaptive ecosystems. They remain the leading cause of disease-related death among children in North America. As we approach computational oncology and Deep Learning Healthcare, our mathematical models of cancer dynamics must be revised. Recent findings support the perspective that cancer-microenvironment interactions may consist of chaotic gene expressions and turbulent protein flows during pattern formation. As such, cancer pattern formation, protein-folding and metastatic invasion are discussed herein as processes driven by chemical turbulence within the framework of complex systems theory. To conclude, cancer stem cells are presented as strange attractors of the Waddington landscape.
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spelling pubmed-75888412020-11-05 Cancer: A turbulence problem() Uthamacumaran, Abicumaran Neoplasia Review article Cancers are complex, adaptive ecosystems. They remain the leading cause of disease-related death among children in North America. As we approach computational oncology and Deep Learning Healthcare, our mathematical models of cancer dynamics must be revised. Recent findings support the perspective that cancer-microenvironment interactions may consist of chaotic gene expressions and turbulent protein flows during pattern formation. As such, cancer pattern formation, protein-folding and metastatic invasion are discussed herein as processes driven by chemical turbulence within the framework of complex systems theory. To conclude, cancer stem cells are presented as strange attractors of the Waddington landscape. Neoplasia Press 2020-10-24 /pmc/articles/PMC7588841/ /pubmed/33142240 http://dx.doi.org/10.1016/j.neo.2020.09.008 Text en © 2020 Published by Elsevier Inc. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review article
Uthamacumaran, Abicumaran
Cancer: A turbulence problem()
title Cancer: A turbulence problem()
title_full Cancer: A turbulence problem()
title_fullStr Cancer: A turbulence problem()
title_full_unstemmed Cancer: A turbulence problem()
title_short Cancer: A turbulence problem()
title_sort cancer: a turbulence problem()
topic Review article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7588841/
https://www.ncbi.nlm.nih.gov/pubmed/33142240
http://dx.doi.org/10.1016/j.neo.2020.09.008
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