The Non-Coding RNA GAS5 and Its Role in Tumor Therapy-Induced Resistance

The growth arrest-specific transcript 5 (GAS5) is a >200-nt lncRNA molecule that regulates several cellular functions, including proliferation, apoptosis, invasion and metastasis, across different types of human cancers. Here, we reviewed the current literature on the expression of GAS5 in leukem...

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Detalles Bibliográficos
Autores principales: Lambrou, George I., Hatziagapiou, Kyriaki, Zaravinos, Apostolos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7588928/
https://www.ncbi.nlm.nih.gov/pubmed/33076450
http://dx.doi.org/10.3390/ijms21207633
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author Lambrou, George I.
Hatziagapiou, Kyriaki
Zaravinos, Apostolos
author_facet Lambrou, George I.
Hatziagapiou, Kyriaki
Zaravinos, Apostolos
author_sort Lambrou, George I.
collection PubMed
description The growth arrest-specific transcript 5 (GAS5) is a >200-nt lncRNA molecule that regulates several cellular functions, including proliferation, apoptosis, invasion and metastasis, across different types of human cancers. Here, we reviewed the current literature on the expression of GAS5 in leukemia, cervical, breast, ovarian, prostate, urinary bladder, lung, gastric, colorectal, liver, osteosarcoma and brain cancers, as well as its interaction with various miRNAs and its effect on therapy-related resistance in these malignancies. The general consensus is that GAS5 acts as a tumor suppressor across different tumor types and that its up-regulation results in tumor sensitization to chemotherapy or radiotherapy. GAS5 seems to play a previously unappreciated, but significant role in tumor therapy-induced resistance.
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spelling pubmed-75889282020-10-29 The Non-Coding RNA GAS5 and Its Role in Tumor Therapy-Induced Resistance Lambrou, George I. Hatziagapiou, Kyriaki Zaravinos, Apostolos Int J Mol Sci Review The growth arrest-specific transcript 5 (GAS5) is a >200-nt lncRNA molecule that regulates several cellular functions, including proliferation, apoptosis, invasion and metastasis, across different types of human cancers. Here, we reviewed the current literature on the expression of GAS5 in leukemia, cervical, breast, ovarian, prostate, urinary bladder, lung, gastric, colorectal, liver, osteosarcoma and brain cancers, as well as its interaction with various miRNAs and its effect on therapy-related resistance in these malignancies. The general consensus is that GAS5 acts as a tumor suppressor across different tumor types and that its up-regulation results in tumor sensitization to chemotherapy or radiotherapy. GAS5 seems to play a previously unappreciated, but significant role in tumor therapy-induced resistance. MDPI 2020-10-15 /pmc/articles/PMC7588928/ /pubmed/33076450 http://dx.doi.org/10.3390/ijms21207633 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lambrou, George I.
Hatziagapiou, Kyriaki
Zaravinos, Apostolos
The Non-Coding RNA GAS5 and Its Role in Tumor Therapy-Induced Resistance
title The Non-Coding RNA GAS5 and Its Role in Tumor Therapy-Induced Resistance
title_full The Non-Coding RNA GAS5 and Its Role in Tumor Therapy-Induced Resistance
title_fullStr The Non-Coding RNA GAS5 and Its Role in Tumor Therapy-Induced Resistance
title_full_unstemmed The Non-Coding RNA GAS5 and Its Role in Tumor Therapy-Induced Resistance
title_short The Non-Coding RNA GAS5 and Its Role in Tumor Therapy-Induced Resistance
title_sort non-coding rna gas5 and its role in tumor therapy-induced resistance
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7588928/
https://www.ncbi.nlm.nih.gov/pubmed/33076450
http://dx.doi.org/10.3390/ijms21207633
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