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Role of microRNAs in Diagnosis, Prognosis and Management of Multiple Myeloma

Multiple myeloma (MM) is a cancerous bone disease characterized by malignant transformation of plasma cells in the bone marrow. MM is considered to be the second most common blood malignancy, with 20,000 new cases reported every year in the USA. Extensive research is currently enduring to validate d...

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Autores principales: Soliman, Amro M., Lin, Teoh Seong, Mahakkanukrauh, Pasuk, Das, Srijit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589124/
https://www.ncbi.nlm.nih.gov/pubmed/33066062
http://dx.doi.org/10.3390/ijms21207539
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author Soliman, Amro M.
Lin, Teoh Seong
Mahakkanukrauh, Pasuk
Das, Srijit
author_facet Soliman, Amro M.
Lin, Teoh Seong
Mahakkanukrauh, Pasuk
Das, Srijit
author_sort Soliman, Amro M.
collection PubMed
description Multiple myeloma (MM) is a cancerous bone disease characterized by malignant transformation of plasma cells in the bone marrow. MM is considered to be the second most common blood malignancy, with 20,000 new cases reported every year in the USA. Extensive research is currently enduring to validate diagnostic and therapeutic means to manage MM. microRNAs (miRNAs) were shown to be dysregulated in MM cases and to have a potential role in either progression or suppression of MM. Therefore, researchers investigated miRNAs levels in MM plasma cells and created tools to test their impact on tumor growth. In the present review, we discuss the most recently discovered miRNAs and their regulation in MM. Furthermore, we emphasized utilizing miRNAs as potential targets in the diagnosis, prognosis and treatment of MM, which can be useful for future clinical management.
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spelling pubmed-75891242020-10-29 Role of microRNAs in Diagnosis, Prognosis and Management of Multiple Myeloma Soliman, Amro M. Lin, Teoh Seong Mahakkanukrauh, Pasuk Das, Srijit Int J Mol Sci Review Multiple myeloma (MM) is a cancerous bone disease characterized by malignant transformation of plasma cells in the bone marrow. MM is considered to be the second most common blood malignancy, with 20,000 new cases reported every year in the USA. Extensive research is currently enduring to validate diagnostic and therapeutic means to manage MM. microRNAs (miRNAs) were shown to be dysregulated in MM cases and to have a potential role in either progression or suppression of MM. Therefore, researchers investigated miRNAs levels in MM plasma cells and created tools to test their impact on tumor growth. In the present review, we discuss the most recently discovered miRNAs and their regulation in MM. Furthermore, we emphasized utilizing miRNAs as potential targets in the diagnosis, prognosis and treatment of MM, which can be useful for future clinical management. MDPI 2020-10-13 /pmc/articles/PMC7589124/ /pubmed/33066062 http://dx.doi.org/10.3390/ijms21207539 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Soliman, Amro M.
Lin, Teoh Seong
Mahakkanukrauh, Pasuk
Das, Srijit
Role of microRNAs in Diagnosis, Prognosis and Management of Multiple Myeloma
title Role of microRNAs in Diagnosis, Prognosis and Management of Multiple Myeloma
title_full Role of microRNAs in Diagnosis, Prognosis and Management of Multiple Myeloma
title_fullStr Role of microRNAs in Diagnosis, Prognosis and Management of Multiple Myeloma
title_full_unstemmed Role of microRNAs in Diagnosis, Prognosis and Management of Multiple Myeloma
title_short Role of microRNAs in Diagnosis, Prognosis and Management of Multiple Myeloma
title_sort role of micrornas in diagnosis, prognosis and management of multiple myeloma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589124/
https://www.ncbi.nlm.nih.gov/pubmed/33066062
http://dx.doi.org/10.3390/ijms21207539
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