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Role of microRNAs in Diagnosis, Prognosis and Management of Multiple Myeloma
Multiple myeloma (MM) is a cancerous bone disease characterized by malignant transformation of plasma cells in the bone marrow. MM is considered to be the second most common blood malignancy, with 20,000 new cases reported every year in the USA. Extensive research is currently enduring to validate d...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589124/ https://www.ncbi.nlm.nih.gov/pubmed/33066062 http://dx.doi.org/10.3390/ijms21207539 |
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author | Soliman, Amro M. Lin, Teoh Seong Mahakkanukrauh, Pasuk Das, Srijit |
author_facet | Soliman, Amro M. Lin, Teoh Seong Mahakkanukrauh, Pasuk Das, Srijit |
author_sort | Soliman, Amro M. |
collection | PubMed |
description | Multiple myeloma (MM) is a cancerous bone disease characterized by malignant transformation of plasma cells in the bone marrow. MM is considered to be the second most common blood malignancy, with 20,000 new cases reported every year in the USA. Extensive research is currently enduring to validate diagnostic and therapeutic means to manage MM. microRNAs (miRNAs) were shown to be dysregulated in MM cases and to have a potential role in either progression or suppression of MM. Therefore, researchers investigated miRNAs levels in MM plasma cells and created tools to test their impact on tumor growth. In the present review, we discuss the most recently discovered miRNAs and their regulation in MM. Furthermore, we emphasized utilizing miRNAs as potential targets in the diagnosis, prognosis and treatment of MM, which can be useful for future clinical management. |
format | Online Article Text |
id | pubmed-7589124 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75891242020-10-29 Role of microRNAs in Diagnosis, Prognosis and Management of Multiple Myeloma Soliman, Amro M. Lin, Teoh Seong Mahakkanukrauh, Pasuk Das, Srijit Int J Mol Sci Review Multiple myeloma (MM) is a cancerous bone disease characterized by malignant transformation of plasma cells in the bone marrow. MM is considered to be the second most common blood malignancy, with 20,000 new cases reported every year in the USA. Extensive research is currently enduring to validate diagnostic and therapeutic means to manage MM. microRNAs (miRNAs) were shown to be dysregulated in MM cases and to have a potential role in either progression or suppression of MM. Therefore, researchers investigated miRNAs levels in MM plasma cells and created tools to test their impact on tumor growth. In the present review, we discuss the most recently discovered miRNAs and their regulation in MM. Furthermore, we emphasized utilizing miRNAs as potential targets in the diagnosis, prognosis and treatment of MM, which can be useful for future clinical management. MDPI 2020-10-13 /pmc/articles/PMC7589124/ /pubmed/33066062 http://dx.doi.org/10.3390/ijms21207539 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Soliman, Amro M. Lin, Teoh Seong Mahakkanukrauh, Pasuk Das, Srijit Role of microRNAs in Diagnosis, Prognosis and Management of Multiple Myeloma |
title | Role of microRNAs in Diagnosis, Prognosis and Management of Multiple Myeloma |
title_full | Role of microRNAs in Diagnosis, Prognosis and Management of Multiple Myeloma |
title_fullStr | Role of microRNAs in Diagnosis, Prognosis and Management of Multiple Myeloma |
title_full_unstemmed | Role of microRNAs in Diagnosis, Prognosis and Management of Multiple Myeloma |
title_short | Role of microRNAs in Diagnosis, Prognosis and Management of Multiple Myeloma |
title_sort | role of micrornas in diagnosis, prognosis and management of multiple myeloma |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589124/ https://www.ncbi.nlm.nih.gov/pubmed/33066062 http://dx.doi.org/10.3390/ijms21207539 |
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