Cargando…

Intimate Relations—Mitochondria and Ageing

Mitochondrial dysfunction is associated with ageing, but the detailed causal relationship between the two is still unclear. We review the major phenomenological manifestations of mitochondrial age-related dysfunction including biochemical, regulatory and energetic features. We conclude that the comp...

Descripción completa

Detalles Bibliográficos
Autores principales: Webb, Michael, Sideris, Dionisia P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589147/
https://www.ncbi.nlm.nih.gov/pubmed/33066461
http://dx.doi.org/10.3390/ijms21207580
_version_ 1783600511709085696
author Webb, Michael
Sideris, Dionisia P.
author_facet Webb, Michael
Sideris, Dionisia P.
author_sort Webb, Michael
collection PubMed
description Mitochondrial dysfunction is associated with ageing, but the detailed causal relationship between the two is still unclear. We review the major phenomenological manifestations of mitochondrial age-related dysfunction including biochemical, regulatory and energetic features. We conclude that the complexity of these processes and their inter-relationships are still not fully understood and at this point it seems unlikely that a single linear cause and effect relationship between any specific aspect of mitochondrial biology and ageing can be established in either direction.
format Online
Article
Text
id pubmed-7589147
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-75891472020-10-29 Intimate Relations—Mitochondria and Ageing Webb, Michael Sideris, Dionisia P. Int J Mol Sci Review Mitochondrial dysfunction is associated with ageing, but the detailed causal relationship between the two is still unclear. We review the major phenomenological manifestations of mitochondrial age-related dysfunction including biochemical, regulatory and energetic features. We conclude that the complexity of these processes and their inter-relationships are still not fully understood and at this point it seems unlikely that a single linear cause and effect relationship between any specific aspect of mitochondrial biology and ageing can be established in either direction. MDPI 2020-10-14 /pmc/articles/PMC7589147/ /pubmed/33066461 http://dx.doi.org/10.3390/ijms21207580 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Webb, Michael
Sideris, Dionisia P.
Intimate Relations—Mitochondria and Ageing
title Intimate Relations—Mitochondria and Ageing
title_full Intimate Relations—Mitochondria and Ageing
title_fullStr Intimate Relations—Mitochondria and Ageing
title_full_unstemmed Intimate Relations—Mitochondria and Ageing
title_short Intimate Relations—Mitochondria and Ageing
title_sort intimate relations—mitochondria and ageing
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589147/
https://www.ncbi.nlm.nih.gov/pubmed/33066461
http://dx.doi.org/10.3390/ijms21207580
work_keys_str_mv AT webbmichael intimaterelationsmitochondriaandageing
AT siderisdionisiap intimaterelationsmitochondriaandageing