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Intimate Relations—Mitochondria and Ageing
Mitochondrial dysfunction is associated with ageing, but the detailed causal relationship between the two is still unclear. We review the major phenomenological manifestations of mitochondrial age-related dysfunction including biochemical, regulatory and energetic features. We conclude that the comp...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589147/ https://www.ncbi.nlm.nih.gov/pubmed/33066461 http://dx.doi.org/10.3390/ijms21207580 |
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author | Webb, Michael Sideris, Dionisia P. |
author_facet | Webb, Michael Sideris, Dionisia P. |
author_sort | Webb, Michael |
collection | PubMed |
description | Mitochondrial dysfunction is associated with ageing, but the detailed causal relationship between the two is still unclear. We review the major phenomenological manifestations of mitochondrial age-related dysfunction including biochemical, regulatory and energetic features. We conclude that the complexity of these processes and their inter-relationships are still not fully understood and at this point it seems unlikely that a single linear cause and effect relationship between any specific aspect of mitochondrial biology and ageing can be established in either direction. |
format | Online Article Text |
id | pubmed-7589147 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75891472020-10-29 Intimate Relations—Mitochondria and Ageing Webb, Michael Sideris, Dionisia P. Int J Mol Sci Review Mitochondrial dysfunction is associated with ageing, but the detailed causal relationship between the two is still unclear. We review the major phenomenological manifestations of mitochondrial age-related dysfunction including biochemical, regulatory and energetic features. We conclude that the complexity of these processes and their inter-relationships are still not fully understood and at this point it seems unlikely that a single linear cause and effect relationship between any specific aspect of mitochondrial biology and ageing can be established in either direction. MDPI 2020-10-14 /pmc/articles/PMC7589147/ /pubmed/33066461 http://dx.doi.org/10.3390/ijms21207580 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Webb, Michael Sideris, Dionisia P. Intimate Relations—Mitochondria and Ageing |
title | Intimate Relations—Mitochondria and Ageing |
title_full | Intimate Relations—Mitochondria and Ageing |
title_fullStr | Intimate Relations—Mitochondria and Ageing |
title_full_unstemmed | Intimate Relations—Mitochondria and Ageing |
title_short | Intimate Relations—Mitochondria and Ageing |
title_sort | intimate relations—mitochondria and ageing |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589147/ https://www.ncbi.nlm.nih.gov/pubmed/33066461 http://dx.doi.org/10.3390/ijms21207580 |
work_keys_str_mv | AT webbmichael intimaterelationsmitochondriaandageing AT siderisdionisiap intimaterelationsmitochondriaandageing |