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Bone Marrow and Adipose Tissue Adenosine Receptors Effect on Osteogenesis and Adipogenesis
Adenosine is an extracellular signaling molecule that is particularly relevant in times of cellular stress, inflammation and metabolic disturbances when the levels of the purine increase. Adenosine acts on two G-protein-coupled stimulatory and on two G-protein-coupled inhibitory receptors, which hav...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589187/ https://www.ncbi.nlm.nih.gov/pubmed/33050467 http://dx.doi.org/10.3390/ijms21207470 |
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author | Eisenstein, Anna Chitalia, Shlok V. Ravid, Katya |
author_facet | Eisenstein, Anna Chitalia, Shlok V. Ravid, Katya |
author_sort | Eisenstein, Anna |
collection | PubMed |
description | Adenosine is an extracellular signaling molecule that is particularly relevant in times of cellular stress, inflammation and metabolic disturbances when the levels of the purine increase. Adenosine acts on two G-protein-coupled stimulatory and on two G-protein-coupled inhibitory receptors, which have varying expression profiles in different tissues and conditions, and have different affinities for the endogenous ligand. Studies point to significant roles of adenosine and its receptors in metabolic disease and bone health, implicating the receptors as potential therapeutic targets. This review will highlight our current understanding of the dichotomous effects of adenosine and its receptors on adipogenesis versus osteogenesis within the bone marrow to maintain bone health, as well as its relationship to obesity. Therapeutic implications will also be reviewed. |
format | Online Article Text |
id | pubmed-7589187 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75891872020-10-29 Bone Marrow and Adipose Tissue Adenosine Receptors Effect on Osteogenesis and Adipogenesis Eisenstein, Anna Chitalia, Shlok V. Ravid, Katya Int J Mol Sci Review Adenosine is an extracellular signaling molecule that is particularly relevant in times of cellular stress, inflammation and metabolic disturbances when the levels of the purine increase. Adenosine acts on two G-protein-coupled stimulatory and on two G-protein-coupled inhibitory receptors, which have varying expression profiles in different tissues and conditions, and have different affinities for the endogenous ligand. Studies point to significant roles of adenosine and its receptors in metabolic disease and bone health, implicating the receptors as potential therapeutic targets. This review will highlight our current understanding of the dichotomous effects of adenosine and its receptors on adipogenesis versus osteogenesis within the bone marrow to maintain bone health, as well as its relationship to obesity. Therapeutic implications will also be reviewed. MDPI 2020-10-10 /pmc/articles/PMC7589187/ /pubmed/33050467 http://dx.doi.org/10.3390/ijms21207470 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Eisenstein, Anna Chitalia, Shlok V. Ravid, Katya Bone Marrow and Adipose Tissue Adenosine Receptors Effect on Osteogenesis and Adipogenesis |
title | Bone Marrow and Adipose Tissue Adenosine Receptors Effect on Osteogenesis and Adipogenesis |
title_full | Bone Marrow and Adipose Tissue Adenosine Receptors Effect on Osteogenesis and Adipogenesis |
title_fullStr | Bone Marrow and Adipose Tissue Adenosine Receptors Effect on Osteogenesis and Adipogenesis |
title_full_unstemmed | Bone Marrow and Adipose Tissue Adenosine Receptors Effect on Osteogenesis and Adipogenesis |
title_short | Bone Marrow and Adipose Tissue Adenosine Receptors Effect on Osteogenesis and Adipogenesis |
title_sort | bone marrow and adipose tissue adenosine receptors effect on osteogenesis and adipogenesis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589187/ https://www.ncbi.nlm.nih.gov/pubmed/33050467 http://dx.doi.org/10.3390/ijms21207470 |
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