Alum triggers infiltration of human neutrophils ex vivo and causes lysosomal destabilization and mitochondrial membrane potential‐dependent NET‐formation

Aluminium salts have been used in vaccines for decades. However, the mechanisms underlying their adjuvant effect are still unclear. Neutrophils, the first immune cells at the injection site, can release cellular DNA together with granular material, so‐called neutrophil extracellular traps (NETs). In...

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Detalles Bibliográficos
Autores principales: Reithofer, Manuel, Karacs, Jasmine, Strobl, Johanna, Kitzmüller, Claudia, Polak, Dominika, Seif, Katharina, Kamalov, Meder, Becker, Christian F. W., Greiner, Georg, Schmetterer, Klaus, Stary, Georg, Bohle, Barbara, Jahn‐Schmid, Beatrice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589265/
https://www.ncbi.nlm.nih.gov/pubmed/32860638
http://dx.doi.org/10.1096/fj.202001413R

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