Cargando…

Characterization of Neurons Expressing the Novel Analgesic Drug Target Somatostatin Receptor 4 in Mouse and Human Brains

Somatostatin is an important mood and pain-regulating neuropeptide, which exerts analgesic, anti-inflammatory, and antidepressant effects via its Gi protein-coupled receptor subtype 4 (SST(4)) without endocrine actions. SST(4) is suggested to be a unique novel drug target for chronic neuropathic pai...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kecskés, Angéla, Pohóczky, Krisztina, Kecskés, Miklós, Varga, Zoltán V., Kormos, Viktória, Szőke, Éva, Henn-Mike, Nóra, Fehér, Máté, Kun, József, Gyenesei, Attila, Renner, Éva, Palkovits, Miklós, Ferdinandy, Péter, Ábrahám, István M., Gaszner, Balázs, Helyes, Zsuzsanna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589422/ https://www.ncbi.nlm.nih.gov/pubmed/33096776 http://dx.doi.org/10.3390/ijms21207788

Ejemplares similares

Peptidergic neurons of the Edinger–Westphal nucleus express TRPA1 ion channel that is downregulated both upon chronic variable mild stress in male mice and in humans who died by suicide
por: Kormos, Viktória, et al.
Publicado: (2022)

Functional Transient Receptor Potential Ankyrin 1 and Vanilloid 1 Ion Channels Are Overexpressed in Human Oral Squamous Cell Carcinoma
por: Kiss, Fruzsina, et al.
Publicado: (2022)

Resolvin D1 and D2 Inhibit Transient Receptor Potential Vanilloid 1 and Ankyrin 1 Ion Channel Activation on Sensory Neurons via Lipid Raft Modification
por: Payrits, Maja, et al.
Publicado: (2020)

Human Somatostatin SST(4) Receptor Transgenic Mice: Construction and Brain Expression Pattern Characterization
por: Nemes, Balázs, et al.
Publicado: (2021)

Synthetic Diphenylacetylene-Based Retinoids Induce DNA Damage in Chinese Hamster Ovary Cells without Altering Viability
por: Hudhud, Lina, et al.
Publicado: (2022)

Hemokinin-1 is a mediator of chronic restraint stress-induced pain
por: Borbély, Éva, et al.
Publicado: (2023)

In Silico, In Vitro and In Vivo Pharmacodynamic Characterization of Novel Analgesic Drug Candidate Somatostatin SST(4) Receptor Agonists
por: Kántás, Boglárka, et al.
Publicado: (2021)

Somatostatin expressing GABAergic interneurons in the medial entorhinal cortex preferentially inhibit layer(III-V) pyramidal cells
por: Kecskés, Miklós, et al.
Publicado: (2020)

Hemokinin-1 Gene Expression Is Upregulated in Trigeminal Ganglia in an Inflammatory Orofacial Pain Model: Potential Role in Peripheral Sensitization
por: Aczél, Timea, et al.
Publicado: (2020)

Functionally active TRPA1 ion channel is downregulated in peptidergic neurons of the Edinger-Westphal nucleus upon acute alcohol exposure
por: Al-Omari, Ammar, et al.
Publicado: (2023)

Dimethyl Trisulfide Diminishes Traumatic Neuropathic Pain Acting on TRPA1 Receptors in Mice
por: Dombi, Ágnes, et al.
Publicado: (2021)

Novel Drug-Like Somatostatin Receptor 4 Agonists are Potential Analgesics for Neuropathic Pain
por: Kántás, Boglárka, et al.
Publicado: (2019)

Somatostatin and Its Receptors in Myocardial Ischemia/Reperfusion Injury and Cardioprotection
por: Vörös, Imre, et al.
Publicado: (2021)

Neurodegeneration in the centrally-projecting Edinger–Westphal nucleus contributes to the non-motor symptoms of Parkinson’s disease in the rat
por: Ujvári, Balázs, et al.
Publicado: (2022)

TRPM4 regulates hilar mossy cell loss in temporal lobe epilepsy
por: Mundrucz, Laura, et al.
Publicado: (2023)

PACAP-38 Induces Transcriptomic Changes in Rat Trigeminal Ganglion Cells Related to Neuroinflammation and Altered Mitochondrial Function Presumably via PAC1/VPAC2 Receptor-Independent Mechanism
por: Takács-Lovász, Krisztina, et al.
Publicado: (2022)

Local upregulation of transient receptor potential ankyrin 1 and transient receptor potential vanilloid 1 ion channels in rectosigmoid deep infiltrating endometriosis
por: Bohonyi, Noémi, et al.
Publicado: (2017)

Hemokinin-1 as a Mediator of Arthritis-Related Pain via Direct Activation of Primary Sensory Neurons
por: Borbély, Éva, et al.
Publicado: (2021)

Hemokinin-1 induces transcriptomic alterations in pain-related signaling processes in rat primary sensory neurons independent of NK1 tachykinin receptor activation
por: Takács-Lovász, Krisztina, et al.
Publicado: (2023)

Editorial: Contribution of ion channels to neuropathologies
por: Kecskes, Miklos, et al.
Publicado: (2023)

The Role of TRPA1 Channels in the Central Processing of Odours Contributing to the Behavioural Responses of Mice
por: Konkoly, János, et al.
Publicado: (2021)

Transcriptional Alterations in the Trigeminal Ganglia, Nucleus and Peripheral Blood Mononuclear Cells in a Rat Orofacial Pain Model
por: Aczél, Timea, et al.
Publicado: (2018)

Is it a face of a woman or a man? Visual mismatch negativity is sensitive to gender category
por: Kecskés-Kovács, Krisztina, et al.
Publicado: (2013)

Transient Receptor Potential (TRP) Channels in Head-and-Neck Squamous Cell Carcinomas: Diagnostic, Prognostic, and Therapeutic Potentials
por: Kiss, Fruzsina, et al.
Publicado: (2020)

Somatostatin Primes Endothelial Cells for Agonist-Induced Hyperpermeability and Angiogenesis In Vitro
por: Aslam, Muhammad, et al.
Publicado: (2022)

Proof-of-Concept for the Analgesic Effect and Thermoregulatory Safety of Orally Administered Multi-Target Compound SZV 1287 in Mice: A Novel Drug Candidate for Neuropathic Pain
por: Horváth, Ádám István, et al.
Publicado: (2021)

Molecular Links between Sensory Nerves, Inflammation, and Pain 2.0
por: Szőke, Éva, et al.
Publicado: (2023)

Exploration of Somatostatin Binding Mechanism to Somatostatin Receptor Subtype 4
por: Börzsei, Rita, et al.
Publicado: (2022)

Editorial: Targeting Neuro-Immuno-Vascular Interactions in the Brain and the Periphery
por: Wilhelm, Imola, et al.
Publicado: (2022)

Transcriptome Profiling of the Dorsomedial Prefrontal Cortex in Suicide Victims
por: Dóra, Fanni, et al.
Publicado: (2022)

Elevated Glucagon-like Peptide-1 Receptor Level in the Paraventricular Hypothalamic Nucleus of Type 2 Diabetes Mellitus Patients
por: Renner, Éva, et al.
Publicado: (2022)

Upregulation of the Transient Receptor Potential Ankyrin 1 Ion Channel in the Inflamed Human and Mouse Colon and Its Protective Roles
por: Kun, József, et al.
Publicado: (2014)

Downregulation of PACAP and the PAC1 Receptor in the Basal Ganglia, Substantia Nigra and Centrally Projecting Edinger–Westphal Nucleus in the Rotenone model of Parkinson’s Disease
por: Fehér, Máté, et al.
Publicado: (2023)

Analgesic Effects of Lipid Raft Disruption by Sphingomyelinase and Myriocin via Transient Receptor Potential Vanilloid 1 and Transient Receptor Potential Ankyrin 1 Ion Channel Modulation
por: Horváth, Ádám, et al.
Publicado: (2021)

Exploratory and locomotor activity, learning and memory functions in somatostatin receptor subtype 4 gene-deficient mice in relation to aging and sex
por: Szentes, Nikolett, et al.
Publicado: (2019)

Nucleoside conjugates of quantum dots for characterization of G protein-coupled receptors: strategies for immobilizing A(2A )adenosine receptor agonists
por: Das, Arijit, et al.
Publicado: (2010)

Co-Aggregation and Parallel Aggregation of Specific Proteins in Major Mental Illness
por: Samardžija, Bobana, et al.
Publicado: (2023)

Saxagliptin Cardiotoxicity in Chronic Heart Failure: The Role of DPP4 in the Regulation of Neuropeptide Tone
por: Vörös, Imre, et al.
Publicado: (2022)

Live-Cell Imaging of Single Neurotrophin Receptor Molecules on Human Neurons in Alzheimer’s Disease
por: Barabás, Klaudia, et al.
Publicado: (2021)

Role of Transient Receptor Potential Ankyrin 1 Ion Channel and Somatostatin sst4 Receptor in the Antinociceptive and Anti-inflammatory Effects of Sodium Polysulfide and Dimethyl Trisulfide
por: Bátai, István Z., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_qp7k2t0b6vk4u0jveaf86g1u8m