T cell-intrinsic role for Nod2 in protection against Th17-mediated uveitis

Mutations in nucleotide-binding oligomerization domain-containing protein 2 (NOD2) cause Blau syndrome, an inflammatory disorder characterized by uveitis. The antimicrobial functions of Nod2 are well-established, yet the cellular mechanisms by which dysregulated Nod2 causes uveitis remain unknown. H...

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Detalles Bibliográficos
Autores principales: Napier, Ruth J., Lee, Ellen J., Davey, Michael P., Vance, Emily E., Furtado, João M., Snow, Paige E., Samson, Kimberly A., Lashley, Sydney J., Brown, Brieanna R., Horai, Reiko, Mattapallil, Mary J., Xu, Biying, Callegan, Michelle C., Uebelhoer, Luke S., Lancioni, Christina L., Vehe, Richard K., Binstadt, Bryce A., Smith, Justine R., Caspi, Rachel R., Rosenzweig, Holly L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589501/
https://www.ncbi.nlm.nih.gov/pubmed/33106495
http://dx.doi.org/10.1038/s41467-020-18961-0

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