A case of simultaneous occurrence of hepatitis and pancreatitis during the combination immunochemotherapy for non-small cell lung carcinoma

Immune checkpoint inhibitors (ICIs) improved the prognosis of patients with advanced lung cancers. The combination therapy of cytotoxic drugs and ICI is approved as first-line chemotherapy in non-small-cell lung cancer (NSCLC) and extensive disease small-cell lung cancer (ED-SCLC). It has been repor...

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Autores principales: Tanaka, Satoshi, Asakawa, Ryo, Komuta, Kiyohide, Tanizaki, Satoshi, Kanai, Tomohiro, Kuroyama, Muneyoshi, Shimazu, Kohki, Uchida, Junji, Yakushijin, Takayuki, Ueno, Kiyonobu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589533/
https://www.ncbi.nlm.nih.gov/pubmed/33134073
http://dx.doi.org/10.1016/j.rmcr.2020.101266
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author Tanaka, Satoshi
Asakawa, Ryo
Komuta, Kiyohide
Tanizaki, Satoshi
Kanai, Tomohiro
Kuroyama, Muneyoshi
Shimazu, Kohki
Uchida, Junji
Yakushijin, Takayuki
Ueno, Kiyonobu
author_facet Tanaka, Satoshi
Asakawa, Ryo
Komuta, Kiyohide
Tanizaki, Satoshi
Kanai, Tomohiro
Kuroyama, Muneyoshi
Shimazu, Kohki
Uchida, Junji
Yakushijin, Takayuki
Ueno, Kiyonobu
author_sort Tanaka, Satoshi
collection PubMed
description Immune checkpoint inhibitors (ICIs) improved the prognosis of patients with advanced lung cancers. The combination therapy of cytotoxic drugs and ICI is approved as first-line chemotherapy in non-small-cell lung cancer (NSCLC) and extensive disease small-cell lung cancer (ED-SCLC). It has been reported various immune-related adverse events (irAEs). We herein report a 65-year-old man with NSCLC who developed hepatitis and pancreatitis simultaneously during the combination immunochemotherapy. In the treatment of hepatitis and pancreatitis, the clinical course was different. In this report, the importance of accurate diagnosis through detailed examination and treatment priority depending on the severity of the symptoms is indicated.
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spelling pubmed-75895332020-10-30 A case of simultaneous occurrence of hepatitis and pancreatitis during the combination immunochemotherapy for non-small cell lung carcinoma Tanaka, Satoshi Asakawa, Ryo Komuta, Kiyohide Tanizaki, Satoshi Kanai, Tomohiro Kuroyama, Muneyoshi Shimazu, Kohki Uchida, Junji Yakushijin, Takayuki Ueno, Kiyonobu Respir Med Case Rep Case Report Immune checkpoint inhibitors (ICIs) improved the prognosis of patients with advanced lung cancers. The combination therapy of cytotoxic drugs and ICI is approved as first-line chemotherapy in non-small-cell lung cancer (NSCLC) and extensive disease small-cell lung cancer (ED-SCLC). It has been reported various immune-related adverse events (irAEs). We herein report a 65-year-old man with NSCLC who developed hepatitis and pancreatitis simultaneously during the combination immunochemotherapy. In the treatment of hepatitis and pancreatitis, the clinical course was different. In this report, the importance of accurate diagnosis through detailed examination and treatment priority depending on the severity of the symptoms is indicated. Elsevier 2020-10-20 /pmc/articles/PMC7589533/ /pubmed/33134073 http://dx.doi.org/10.1016/j.rmcr.2020.101266 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Tanaka, Satoshi
Asakawa, Ryo
Komuta, Kiyohide
Tanizaki, Satoshi
Kanai, Tomohiro
Kuroyama, Muneyoshi
Shimazu, Kohki
Uchida, Junji
Yakushijin, Takayuki
Ueno, Kiyonobu
A case of simultaneous occurrence of hepatitis and pancreatitis during the combination immunochemotherapy for non-small cell lung carcinoma
title A case of simultaneous occurrence of hepatitis and pancreatitis during the combination immunochemotherapy for non-small cell lung carcinoma
title_full A case of simultaneous occurrence of hepatitis and pancreatitis during the combination immunochemotherapy for non-small cell lung carcinoma
title_fullStr A case of simultaneous occurrence of hepatitis and pancreatitis during the combination immunochemotherapy for non-small cell lung carcinoma
title_full_unstemmed A case of simultaneous occurrence of hepatitis and pancreatitis during the combination immunochemotherapy for non-small cell lung carcinoma
title_short A case of simultaneous occurrence of hepatitis and pancreatitis during the combination immunochemotherapy for non-small cell lung carcinoma
title_sort case of simultaneous occurrence of hepatitis and pancreatitis during the combination immunochemotherapy for non-small cell lung carcinoma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589533/
https://www.ncbi.nlm.nih.gov/pubmed/33134073
http://dx.doi.org/10.1016/j.rmcr.2020.101266
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