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Relationship between Virulence and Resistance among Gram-Negative Bacteria

Bacteria present in the human body are innocuous, providing beneficial functions, some of which are necessary for correct body function. However, other bacteria are able to colonize, invade, and cause damage to different tissues, and these are categorised as pathogens. These pathogenic bacteria poss...

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Autores principales: Cepas, Virginio, Soto, Sara M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589547/
https://www.ncbi.nlm.nih.gov/pubmed/33092201
http://dx.doi.org/10.3390/antibiotics9100719
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author Cepas, Virginio
Soto, Sara M.
author_facet Cepas, Virginio
Soto, Sara M.
author_sort Cepas, Virginio
collection PubMed
description Bacteria present in the human body are innocuous, providing beneficial functions, some of which are necessary for correct body function. However, other bacteria are able to colonize, invade, and cause damage to different tissues, and these are categorised as pathogens. These pathogenic bacteria possess several factors that enable them to be more virulent and cause infection. Bacteria have a great capacity to adapt to different niches and environmental conditions (presence of antibiotics, iron depletion, etc.). Antibiotic pressure has favoured the emergence and spread of antibiotic-resistant bacteria worldwide. Several studies have reported the presence of a relationship (both positive and negative, and both direct and indirect) between antimicrobial resistance and virulence among bacterial pathogens. This review studies the relationship among the most important Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa) taking into account two points of view: (i) the effect the acquisition of resistance has on virulence, and (ii) co-selection of resistance and virulence. The relationship between resistance and virulence among bacteria depends on the bacterial species, the specific mechanisms of resistance and virulence, the ecological niche, and the host.
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spelling pubmed-75895472020-10-29 Relationship between Virulence and Resistance among Gram-Negative Bacteria Cepas, Virginio Soto, Sara M. Antibiotics (Basel) Review Bacteria present in the human body are innocuous, providing beneficial functions, some of which are necessary for correct body function. However, other bacteria are able to colonize, invade, and cause damage to different tissues, and these are categorised as pathogens. These pathogenic bacteria possess several factors that enable them to be more virulent and cause infection. Bacteria have a great capacity to adapt to different niches and environmental conditions (presence of antibiotics, iron depletion, etc.). Antibiotic pressure has favoured the emergence and spread of antibiotic-resistant bacteria worldwide. Several studies have reported the presence of a relationship (both positive and negative, and both direct and indirect) between antimicrobial resistance and virulence among bacterial pathogens. This review studies the relationship among the most important Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa) taking into account two points of view: (i) the effect the acquisition of resistance has on virulence, and (ii) co-selection of resistance and virulence. The relationship between resistance and virulence among bacteria depends on the bacterial species, the specific mechanisms of resistance and virulence, the ecological niche, and the host. MDPI 2020-10-20 /pmc/articles/PMC7589547/ /pubmed/33092201 http://dx.doi.org/10.3390/antibiotics9100719 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Cepas, Virginio
Soto, Sara M.
Relationship between Virulence and Resistance among Gram-Negative Bacteria
title Relationship between Virulence and Resistance among Gram-Negative Bacteria
title_full Relationship between Virulence and Resistance among Gram-Negative Bacteria
title_fullStr Relationship between Virulence and Resistance among Gram-Negative Bacteria
title_full_unstemmed Relationship between Virulence and Resistance among Gram-Negative Bacteria
title_short Relationship between Virulence and Resistance among Gram-Negative Bacteria
title_sort relationship between virulence and resistance among gram-negative bacteria
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589547/
https://www.ncbi.nlm.nih.gov/pubmed/33092201
http://dx.doi.org/10.3390/antibiotics9100719
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