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Emerging Roles of Single-Cell Multi-Omics in Studying Developmental Temporal Patterning
The complexity of brain structure and function is rooted in the precise spatial and temporal regulation of selective developmental events. During neurogenesis, both vertebrates and invertebrates generate a wide variety of specialized cell types through the expansion and specification of a restricted...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589732/ https://www.ncbi.nlm.nih.gov/pubmed/33050604 http://dx.doi.org/10.3390/ijms21207491 |
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author | Lopes, Andrea Magrinelli, Elia Telley, Ludovic |
author_facet | Lopes, Andrea Magrinelli, Elia Telley, Ludovic |
author_sort | Lopes, Andrea |
collection | PubMed |
description | The complexity of brain structure and function is rooted in the precise spatial and temporal regulation of selective developmental events. During neurogenesis, both vertebrates and invertebrates generate a wide variety of specialized cell types through the expansion and specification of a restricted set of neuronal progenitors. Temporal patterning of neural progenitors rests on fine regulation between cell-intrinsic and cell-extrinsic mechanisms. The rapid emergence of high-throughput single-cell technologies combined with elaborate computational analysis has started to provide us with unprecedented biological insights related to temporal patterning in the developing central nervous system (CNS). Here, we present an overview of recent advances in Drosophila and vertebrates, focusing both on cell-intrinsic mechanisms and environmental influences. We then describe the various multi-omics approaches that have strongly contributed to our current understanding and discuss perspectives on the various -omics approaches that hold great potential for the future of temporal patterning research. |
format | Online Article Text |
id | pubmed-7589732 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75897322020-10-29 Emerging Roles of Single-Cell Multi-Omics in Studying Developmental Temporal Patterning Lopes, Andrea Magrinelli, Elia Telley, Ludovic Int J Mol Sci Review The complexity of brain structure and function is rooted in the precise spatial and temporal regulation of selective developmental events. During neurogenesis, both vertebrates and invertebrates generate a wide variety of specialized cell types through the expansion and specification of a restricted set of neuronal progenitors. Temporal patterning of neural progenitors rests on fine regulation between cell-intrinsic and cell-extrinsic mechanisms. The rapid emergence of high-throughput single-cell technologies combined with elaborate computational analysis has started to provide us with unprecedented biological insights related to temporal patterning in the developing central nervous system (CNS). Here, we present an overview of recent advances in Drosophila and vertebrates, focusing both on cell-intrinsic mechanisms and environmental influences. We then describe the various multi-omics approaches that have strongly contributed to our current understanding and discuss perspectives on the various -omics approaches that hold great potential for the future of temporal patterning research. MDPI 2020-10-11 /pmc/articles/PMC7589732/ /pubmed/33050604 http://dx.doi.org/10.3390/ijms21207491 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Lopes, Andrea Magrinelli, Elia Telley, Ludovic Emerging Roles of Single-Cell Multi-Omics in Studying Developmental Temporal Patterning |
title | Emerging Roles of Single-Cell Multi-Omics in Studying Developmental Temporal Patterning |
title_full | Emerging Roles of Single-Cell Multi-Omics in Studying Developmental Temporal Patterning |
title_fullStr | Emerging Roles of Single-Cell Multi-Omics in Studying Developmental Temporal Patterning |
title_full_unstemmed | Emerging Roles of Single-Cell Multi-Omics in Studying Developmental Temporal Patterning |
title_short | Emerging Roles of Single-Cell Multi-Omics in Studying Developmental Temporal Patterning |
title_sort | emerging roles of single-cell multi-omics in studying developmental temporal patterning |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589732/ https://www.ncbi.nlm.nih.gov/pubmed/33050604 http://dx.doi.org/10.3390/ijms21207491 |
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