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Structural Insights into the Active Site Formation of DUSP22 in N-loop-containing Protein Tyrosine Phosphatases

Cysteine-based protein tyrosine phosphatases (Cys-based PTPs) perform dephosphorylation to regulate signaling pathways in cellular responses. The hydrogen bonding network in their active site plays an important conformational role and supports the phosphatase activity. Nearly half of dual-specificit...

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Detalles Bibliográficos
Autores principales:	Lai, Chih-Hsuan, Chang, Co-Chih, Chuang, Huai-Chia, Tan, Tse-Hua, Lyu, Ping-Chiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589817/ https://www.ncbi.nlm.nih.gov/pubmed/33053837 http://dx.doi.org/10.3390/ijms21207515

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