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Fluid-Structure Interaction Analysis on Membrane Behavior of a Microfluidic Passive Valve

In this paper, the effect of membrane features on flow characteristics in the microfluidic passive valve (MPV) and the membrane behavior against fluid flow are studied using the fluid-structure interaction (FSI) analysis. Firstly, the microvalve model with different numbers of microholes and pitches...

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Autores principales: Lin, Zhen-hao, Li, Xiao-juan, Jin, Zhi-jiang, Qian, Jin-yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589823/
https://www.ncbi.nlm.nih.gov/pubmed/33096936
http://dx.doi.org/10.3390/membranes10100300
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author Lin, Zhen-hao
Li, Xiao-juan
Jin, Zhi-jiang
Qian, Jin-yuan
author_facet Lin, Zhen-hao
Li, Xiao-juan
Jin, Zhi-jiang
Qian, Jin-yuan
author_sort Lin, Zhen-hao
collection PubMed
description In this paper, the effect of membrane features on flow characteristics in the microfluidic passive valve (MPV) and the membrane behavior against fluid flow are studied using the fluid-structure interaction (FSI) analysis. Firstly, the microvalve model with different numbers of microholes and pitches of microholes are designed to investigate the flow rate of the MPV. The result shows that the number of microholes on the membrane has a significant impact on the flow rate of the MPV, while the pitch of microholes has little effect on it. The constant flow rate maintained by the microvalve (the number of microholes n = 4) is 5.75 mL/min, and the threshold pressure to achieve the flow rate is 4 kPa. Secondly, the behavior of the membrane against the fluid flow is analyzed. The result shows that as the inlet pressure increases, the flow resistance of the MPV increases rapidly, and the deformation of the membrane gradually becomes stable. Finally, the effect of the membrane material on the flow rate and the deformation of the membrane are studied. The result shows that changes in the material properties of the membrane cause a decrease in the amount of deformation in all stages the all positions of the membrane. This work may provide valuable guidance for the optimization of microfluidic passive valve in microfluidic system.
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spelling pubmed-75898232020-10-29 Fluid-Structure Interaction Analysis on Membrane Behavior of a Microfluidic Passive Valve Lin, Zhen-hao Li, Xiao-juan Jin, Zhi-jiang Qian, Jin-yuan Membranes (Basel) Article In this paper, the effect of membrane features on flow characteristics in the microfluidic passive valve (MPV) and the membrane behavior against fluid flow are studied using the fluid-structure interaction (FSI) analysis. Firstly, the microvalve model with different numbers of microholes and pitches of microholes are designed to investigate the flow rate of the MPV. The result shows that the number of microholes on the membrane has a significant impact on the flow rate of the MPV, while the pitch of microholes has little effect on it. The constant flow rate maintained by the microvalve (the number of microholes n = 4) is 5.75 mL/min, and the threshold pressure to achieve the flow rate is 4 kPa. Secondly, the behavior of the membrane against the fluid flow is analyzed. The result shows that as the inlet pressure increases, the flow resistance of the MPV increases rapidly, and the deformation of the membrane gradually becomes stable. Finally, the effect of the membrane material on the flow rate and the deformation of the membrane are studied. The result shows that changes in the material properties of the membrane cause a decrease in the amount of deformation in all stages the all positions of the membrane. This work may provide valuable guidance for the optimization of microfluidic passive valve in microfluidic system. MDPI 2020-10-21 /pmc/articles/PMC7589823/ /pubmed/33096936 http://dx.doi.org/10.3390/membranes10100300 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lin, Zhen-hao
Li, Xiao-juan
Jin, Zhi-jiang
Qian, Jin-yuan
Fluid-Structure Interaction Analysis on Membrane Behavior of a Microfluidic Passive Valve
title Fluid-Structure Interaction Analysis on Membrane Behavior of a Microfluidic Passive Valve
title_full Fluid-Structure Interaction Analysis on Membrane Behavior of a Microfluidic Passive Valve
title_fullStr Fluid-Structure Interaction Analysis on Membrane Behavior of a Microfluidic Passive Valve
title_full_unstemmed Fluid-Structure Interaction Analysis on Membrane Behavior of a Microfluidic Passive Valve
title_short Fluid-Structure Interaction Analysis on Membrane Behavior of a Microfluidic Passive Valve
title_sort fluid-structure interaction analysis on membrane behavior of a microfluidic passive valve
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589823/
https://www.ncbi.nlm.nih.gov/pubmed/33096936
http://dx.doi.org/10.3390/membranes10100300
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