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Alginate: From Food Industry to Biomedical Applications and Management of Metabolic Disorders

Initially used extensively as an additive and ingredient in the food industry, alginate has become an important compound for a wide range of industries and applications, such as the medical, pharmaceutical and cosmetics sectors. In the food industry, alginate has been used to coat fruits and vegetab...

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Autores principales: Gheorghita Puscaselu, Roxana, Lobiuc, Andrei, Dimian, Mihai, Covasa, Mihai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589871/
https://www.ncbi.nlm.nih.gov/pubmed/33092194
http://dx.doi.org/10.3390/polym12102417
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author Gheorghita Puscaselu, Roxana
Lobiuc, Andrei
Dimian, Mihai
Covasa, Mihai
author_facet Gheorghita Puscaselu, Roxana
Lobiuc, Andrei
Dimian, Mihai
Covasa, Mihai
author_sort Gheorghita Puscaselu, Roxana
collection PubMed
description Initially used extensively as an additive and ingredient in the food industry, alginate has become an important compound for a wide range of industries and applications, such as the medical, pharmaceutical and cosmetics sectors. In the food industry, alginate has been used to coat fruits and vegetables, as a microbial and viral protection product, and as a gelling, thickening, stabilizing or emulsifying agent. Its biocompatibility, biodegradability, nontoxicity and the possibility of it being used in quantum satis doses prompted scientists to explore new properties for alginate usage. Thus, the use of alginate has been expanded so as to be directed towards the pharmaceutical and biomedical industries, where studies have shown that it can be used successfully as biomaterial for wound, hydrogel, and aerogel dressings, among others. Furthermore, the ability to encapsulate natural substances has led to the possibility of using alginate as a drug coating and drug delivery agent, including the encapsulation of probiotics. This is important considering the fact that, until recently, encapsulation and coating agents used in the pharmaceutical industry were limited to the use of lactose, a potentially allergenic agent or gelatin. Obtained at a relatively low cost from marine brown algae, this hydrocolloid can also be used as a potential tool in the management of diabetes, not only as an insulin delivery agent but also due to its ability to improve insulin resistance, attenuate chronic inflammation and decrease oxidative stress. In addition, alginate has been recognized as a potential weight loss treatment, as alginate supplementation has been used as an adjunct treatment to energy restriction, to enhance satiety and improve weight loss in obese individuals. Thus, alginate holds the promise of an effective product used in the food industry as well as in the management of metabolic disorders such as diabetes and obesity. This review highlights recent research advances on the characteristics of alginate and brings to the forefront the beneficial aspects of using alginate, from the food industry to the biomedical field.
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spelling pubmed-75898712020-10-29 Alginate: From Food Industry to Biomedical Applications and Management of Metabolic Disorders Gheorghita Puscaselu, Roxana Lobiuc, Andrei Dimian, Mihai Covasa, Mihai Polymers (Basel) Review Initially used extensively as an additive and ingredient in the food industry, alginate has become an important compound for a wide range of industries and applications, such as the medical, pharmaceutical and cosmetics sectors. In the food industry, alginate has been used to coat fruits and vegetables, as a microbial and viral protection product, and as a gelling, thickening, stabilizing or emulsifying agent. Its biocompatibility, biodegradability, nontoxicity and the possibility of it being used in quantum satis doses prompted scientists to explore new properties for alginate usage. Thus, the use of alginate has been expanded so as to be directed towards the pharmaceutical and biomedical industries, where studies have shown that it can be used successfully as biomaterial for wound, hydrogel, and aerogel dressings, among others. Furthermore, the ability to encapsulate natural substances has led to the possibility of using alginate as a drug coating and drug delivery agent, including the encapsulation of probiotics. This is important considering the fact that, until recently, encapsulation and coating agents used in the pharmaceutical industry were limited to the use of lactose, a potentially allergenic agent or gelatin. Obtained at a relatively low cost from marine brown algae, this hydrocolloid can also be used as a potential tool in the management of diabetes, not only as an insulin delivery agent but also due to its ability to improve insulin resistance, attenuate chronic inflammation and decrease oxidative stress. In addition, alginate has been recognized as a potential weight loss treatment, as alginate supplementation has been used as an adjunct treatment to energy restriction, to enhance satiety and improve weight loss in obese individuals. Thus, alginate holds the promise of an effective product used in the food industry as well as in the management of metabolic disorders such as diabetes and obesity. This review highlights recent research advances on the characteristics of alginate and brings to the forefront the beneficial aspects of using alginate, from the food industry to the biomedical field. MDPI 2020-10-20 /pmc/articles/PMC7589871/ /pubmed/33092194 http://dx.doi.org/10.3390/polym12102417 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gheorghita Puscaselu, Roxana
Lobiuc, Andrei
Dimian, Mihai
Covasa, Mihai
Alginate: From Food Industry to Biomedical Applications and Management of Metabolic Disorders
title Alginate: From Food Industry to Biomedical Applications and Management of Metabolic Disorders
title_full Alginate: From Food Industry to Biomedical Applications and Management of Metabolic Disorders
title_fullStr Alginate: From Food Industry to Biomedical Applications and Management of Metabolic Disorders
title_full_unstemmed Alginate: From Food Industry to Biomedical Applications and Management of Metabolic Disorders
title_short Alginate: From Food Industry to Biomedical Applications and Management of Metabolic Disorders
title_sort alginate: from food industry to biomedical applications and management of metabolic disorders
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589871/
https://www.ncbi.nlm.nih.gov/pubmed/33092194
http://dx.doi.org/10.3390/polym12102417
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