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Improved Diagnostic Accuracy of Bone Metastasis Detection by Water-HAP Associated to Non-Contrast CT

We examined whether water-hydroxyapatite (HAP) images improve the diagnostic accuracy of bone metastasis compared with non-contrast CT alone. We retrospectively evaluated dual-energy computed tomography (DECT) images of 83 cancer patients (bone metastasis, 31; without bone metastasis, 52) from May 2...

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Autores principales: Ishiwata, Yoshinobu, Hieda, Yojiro, Kaki, Soichiro, Aso, Shinjiro, Horie, Keiichi, Kobayashi, Yusuke, Nakamura, Motoki, Yamada, Kazuhiko, Yamashiro, Tsuneo, Utsunomiya, Daisuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589875/
https://www.ncbi.nlm.nih.gov/pubmed/33092274
http://dx.doi.org/10.3390/diagnostics10100853
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author Ishiwata, Yoshinobu
Hieda, Yojiro
Kaki, Soichiro
Aso, Shinjiro
Horie, Keiichi
Kobayashi, Yusuke
Nakamura, Motoki
Yamada, Kazuhiko
Yamashiro, Tsuneo
Utsunomiya, Daisuke
author_facet Ishiwata, Yoshinobu
Hieda, Yojiro
Kaki, Soichiro
Aso, Shinjiro
Horie, Keiichi
Kobayashi, Yusuke
Nakamura, Motoki
Yamada, Kazuhiko
Yamashiro, Tsuneo
Utsunomiya, Daisuke
author_sort Ishiwata, Yoshinobu
collection PubMed
description We examined whether water-hydroxyapatite (HAP) images improve the diagnostic accuracy of bone metastasis compared with non-contrast CT alone. We retrospectively evaluated dual-energy computed tomography (DECT) images of 83 cancer patients (bone metastasis, 31; without bone metastasis, 52) from May 2018 to June 2019. Initially, two evaluators examined for bone metastasis on conventional CT images. In the second session, both CT and CT images plus water-HAP images on DECT. The confidence of bone metastasis was scored from 1 (benign) to 5 (malignant). The sensitivity, specificity, positive predictive values, and negative predictive values for both modalities were calculated based on true positive and negative findings. The intra-observer area under curve (AUC) for detecting bone metastasis was compared by receiver operating characteristic analysis. Kappa coefficient calculated the inter-observer agreement. In conventional CT images, sensitivity, specificity, positive predictive value, and negative predictive value of raters 1 and 2 for the identification of bone metastases were 0.742 and 0.710, 0.981 and 0.981, 0.958 and 0.957, and 0.864 and 0.850, respectively. In water-HAP, they were 1.00 and 1.00, 0.981 and 1.00, 0.969 and 1.00, and 1.00 and 1.00, respectively. In CT, AUCs were 0.861 and 0.845 in each observer. On water-HAP images, AUCs were 0.990 and 1.00. Kappa coefficient was 0.964 for CT and 0.976 for water-HAP images. The combination of CT and water-HAP images significantly increased diagnostic accuracy for detecting bone metastasis. Water-HAP images on DECT may enable accurate initial staging, reduced radiation exposure, and cost.
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spelling pubmed-75898752020-10-29 Improved Diagnostic Accuracy of Bone Metastasis Detection by Water-HAP Associated to Non-Contrast CT Ishiwata, Yoshinobu Hieda, Yojiro Kaki, Soichiro Aso, Shinjiro Horie, Keiichi Kobayashi, Yusuke Nakamura, Motoki Yamada, Kazuhiko Yamashiro, Tsuneo Utsunomiya, Daisuke Diagnostics (Basel) Article We examined whether water-hydroxyapatite (HAP) images improve the diagnostic accuracy of bone metastasis compared with non-contrast CT alone. We retrospectively evaluated dual-energy computed tomography (DECT) images of 83 cancer patients (bone metastasis, 31; without bone metastasis, 52) from May 2018 to June 2019. Initially, two evaluators examined for bone metastasis on conventional CT images. In the second session, both CT and CT images plus water-HAP images on DECT. The confidence of bone metastasis was scored from 1 (benign) to 5 (malignant). The sensitivity, specificity, positive predictive values, and negative predictive values for both modalities were calculated based on true positive and negative findings. The intra-observer area under curve (AUC) for detecting bone metastasis was compared by receiver operating characteristic analysis. Kappa coefficient calculated the inter-observer agreement. In conventional CT images, sensitivity, specificity, positive predictive value, and negative predictive value of raters 1 and 2 for the identification of bone metastases were 0.742 and 0.710, 0.981 and 0.981, 0.958 and 0.957, and 0.864 and 0.850, respectively. In water-HAP, they were 1.00 and 1.00, 0.981 and 1.00, 0.969 and 1.00, and 1.00 and 1.00, respectively. In CT, AUCs were 0.861 and 0.845 in each observer. On water-HAP images, AUCs were 0.990 and 1.00. Kappa coefficient was 0.964 for CT and 0.976 for water-HAP images. The combination of CT and water-HAP images significantly increased diagnostic accuracy for detecting bone metastasis. Water-HAP images on DECT may enable accurate initial staging, reduced radiation exposure, and cost. MDPI 2020-10-20 /pmc/articles/PMC7589875/ /pubmed/33092274 http://dx.doi.org/10.3390/diagnostics10100853 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ishiwata, Yoshinobu
Hieda, Yojiro
Kaki, Soichiro
Aso, Shinjiro
Horie, Keiichi
Kobayashi, Yusuke
Nakamura, Motoki
Yamada, Kazuhiko
Yamashiro, Tsuneo
Utsunomiya, Daisuke
Improved Diagnostic Accuracy of Bone Metastasis Detection by Water-HAP Associated to Non-Contrast CT
title Improved Diagnostic Accuracy of Bone Metastasis Detection by Water-HAP Associated to Non-Contrast CT
title_full Improved Diagnostic Accuracy of Bone Metastasis Detection by Water-HAP Associated to Non-Contrast CT
title_fullStr Improved Diagnostic Accuracy of Bone Metastasis Detection by Water-HAP Associated to Non-Contrast CT
title_full_unstemmed Improved Diagnostic Accuracy of Bone Metastasis Detection by Water-HAP Associated to Non-Contrast CT
title_short Improved Diagnostic Accuracy of Bone Metastasis Detection by Water-HAP Associated to Non-Contrast CT
title_sort improved diagnostic accuracy of bone metastasis detection by water-hap associated to non-contrast ct
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589875/
https://www.ncbi.nlm.nih.gov/pubmed/33092274
http://dx.doi.org/10.3390/diagnostics10100853
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