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Altered Gut Microbiome and Environmental Factors Associated with Development of Eczema in Hong Kong Infants: A 4-Month Pilot Study

Eczema is a multifactorial skin disease that affects 20% of children worldwide and has a complex relationship with microbial, nutritional, parental and environmental factors. In this study, we investigated the potential association of eczema with the gut microbiome and environmental factors. One hun...

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Autores principales: Chan, Carmen Wing Han, Yuet Wa Chan, Judy, Leung, Ting Fan, Choi, Kai Chow, Tsui, Stephen Kwok Wing, Wong, Cho Lee, Chow, Ka Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589899/
https://www.ncbi.nlm.nih.gov/pubmed/33092052
http://dx.doi.org/10.3390/ijerph17207634
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author Chan, Carmen Wing Han
Yuet Wa Chan, Judy
Leung, Ting Fan
Choi, Kai Chow
Tsui, Stephen Kwok Wing
Wong, Cho Lee
Chow, Ka Ming
author_facet Chan, Carmen Wing Han
Yuet Wa Chan, Judy
Leung, Ting Fan
Choi, Kai Chow
Tsui, Stephen Kwok Wing
Wong, Cho Lee
Chow, Ka Ming
author_sort Chan, Carmen Wing Han
collection PubMed
description Eczema is a multifactorial skin disease that affects 20% of children worldwide and has a complex relationship with microbial, nutritional, parental and environmental factors. In this study, we investigated the potential association of eczema with the gut microbiome and environmental factors. One hundred and fifty-two newborn subjects and their mothers were recruited within 10 days postnatally at the Prince of Wales Hospital in Hong Kong, China and asked to complete questionnaires on allergies, maternal diet and environmental assessment at enrolment. Then, the participants were classified as with or without eczema at four months after birth based on the Comprehensive Early Childhood Allergy Questionnaire (CECAQ) and SCORing Atopic Dermatitis (SCORAD) index (n = 48, with 24 in each group). Stool samples were collected from both groups at the same time. Microbial DNA was extracted from each stool sample, and 16S rRNA sequencing was performed to analyze the gut microbiome profiles of the subjects. Our results indicated that the abundance of Bifidobacterium was significantly higher in the eczema group than in the control group (p = 0.04). A multivariable logistic regression analysis was conducted, and the results showed that the father’s education level and maternal intake of cereal products and nutritional supplements during pregnancy were associated with the development of eczema (p = 0.008, 0.032 and 0.015, respectively). In conclusion, this study provided preliminary information about the potential risk factors of eczema development in Hong Kong infants in support of a future full study.
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spelling pubmed-75898992020-10-29 Altered Gut Microbiome and Environmental Factors Associated with Development of Eczema in Hong Kong Infants: A 4-Month Pilot Study Chan, Carmen Wing Han Yuet Wa Chan, Judy Leung, Ting Fan Choi, Kai Chow Tsui, Stephen Kwok Wing Wong, Cho Lee Chow, Ka Ming Int J Environ Res Public Health Article Eczema is a multifactorial skin disease that affects 20% of children worldwide and has a complex relationship with microbial, nutritional, parental and environmental factors. In this study, we investigated the potential association of eczema with the gut microbiome and environmental factors. One hundred and fifty-two newborn subjects and their mothers were recruited within 10 days postnatally at the Prince of Wales Hospital in Hong Kong, China and asked to complete questionnaires on allergies, maternal diet and environmental assessment at enrolment. Then, the participants were classified as with or without eczema at four months after birth based on the Comprehensive Early Childhood Allergy Questionnaire (CECAQ) and SCORing Atopic Dermatitis (SCORAD) index (n = 48, with 24 in each group). Stool samples were collected from both groups at the same time. Microbial DNA was extracted from each stool sample, and 16S rRNA sequencing was performed to analyze the gut microbiome profiles of the subjects. Our results indicated that the abundance of Bifidobacterium was significantly higher in the eczema group than in the control group (p = 0.04). A multivariable logistic regression analysis was conducted, and the results showed that the father’s education level and maternal intake of cereal products and nutritional supplements during pregnancy were associated with the development of eczema (p = 0.008, 0.032 and 0.015, respectively). In conclusion, this study provided preliminary information about the potential risk factors of eczema development in Hong Kong infants in support of a future full study. MDPI 2020-10-20 2020-10 /pmc/articles/PMC7589899/ /pubmed/33092052 http://dx.doi.org/10.3390/ijerph17207634 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chan, Carmen Wing Han
Yuet Wa Chan, Judy
Leung, Ting Fan
Choi, Kai Chow
Tsui, Stephen Kwok Wing
Wong, Cho Lee
Chow, Ka Ming
Altered Gut Microbiome and Environmental Factors Associated with Development of Eczema in Hong Kong Infants: A 4-Month Pilot Study
title Altered Gut Microbiome and Environmental Factors Associated with Development of Eczema in Hong Kong Infants: A 4-Month Pilot Study
title_full Altered Gut Microbiome and Environmental Factors Associated with Development of Eczema in Hong Kong Infants: A 4-Month Pilot Study
title_fullStr Altered Gut Microbiome and Environmental Factors Associated with Development of Eczema in Hong Kong Infants: A 4-Month Pilot Study
title_full_unstemmed Altered Gut Microbiome and Environmental Factors Associated with Development of Eczema in Hong Kong Infants: A 4-Month Pilot Study
title_short Altered Gut Microbiome and Environmental Factors Associated with Development of Eczema in Hong Kong Infants: A 4-Month Pilot Study
title_sort altered gut microbiome and environmental factors associated with development of eczema in hong kong infants: a 4-month pilot study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589899/
https://www.ncbi.nlm.nih.gov/pubmed/33092052
http://dx.doi.org/10.3390/ijerph17207634
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