Binding Mode Exploration of B1 Receptor Antagonists’ by the Use of Molecular Dynamics and Docking Simulation—How Different Target Engagement Can Determine Different Biological Effects

The kinin B1 receptor plays a critical role in the chronic phase of pain and inflammation. The development of B1 antagonists peaked in recent years but almost all promising molecules failed in clinical trials. Little is known about these molecules’ mechanisms of action and additional information wil...

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Detalles Bibliográficos
Autores principales: Gemei, Marica, Talarico, Carmine, Brandolini, Laura, Manelfi, Candida, Za, Lorena, Bovolenta, Silvia, Liberati, Chiara, Del Vecchio, Luigi, Russo, Roberto, Cerchia, Carmen, Allegretti, Marcello, Beccari, Andrea Rosario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7590058/
https://www.ncbi.nlm.nih.gov/pubmed/33081372
http://dx.doi.org/10.3390/ijms21207677

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