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Effect of Silymarin Supplementation on Physical Performance, Muscle and Myocardium Histological Changes, Bodyweight, and Food Consumption in Rats Subjected to Regular Exercise Training

(1) Background: Regular exercise induces physiological and morphological changes in the organisms, but excessive training loads may induce damage and impair recovery or muscle growth. The purpose of the study was to evaluate the impact of Silymarin (SM) consumption on endurance capacity, muscle/card...

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Autores principales: Vargas-Mendoza, Nancy, Ángeles-Valencia, Marcelo, Madrigal-Santillán, Eduardo Osiris, Morales-Martínez, Mauricio, Tirado-Lule, Judith Margarita, Solano-Urrusquieta, Arturo, Madrigal-Bujaidar, Eduardo, Álvarez-González, Isela, Fregoso-Aguilar, Tomás, Morales-González, Ángel, Morales-González, José A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7590064/
https://www.ncbi.nlm.nih.gov/pubmed/33086540
http://dx.doi.org/10.3390/ijms21207724
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author Vargas-Mendoza, Nancy
Ángeles-Valencia, Marcelo
Madrigal-Santillán, Eduardo Osiris
Morales-Martínez, Mauricio
Tirado-Lule, Judith Margarita
Solano-Urrusquieta, Arturo
Madrigal-Bujaidar, Eduardo
Álvarez-González, Isela
Fregoso-Aguilar, Tomás
Morales-González, Ángel
Morales-González, José A.
author_facet Vargas-Mendoza, Nancy
Ángeles-Valencia, Marcelo
Madrigal-Santillán, Eduardo Osiris
Morales-Martínez, Mauricio
Tirado-Lule, Judith Margarita
Solano-Urrusquieta, Arturo
Madrigal-Bujaidar, Eduardo
Álvarez-González, Isela
Fregoso-Aguilar, Tomás
Morales-González, Ángel
Morales-González, José A.
author_sort Vargas-Mendoza, Nancy
collection PubMed
description (1) Background: Regular exercise induces physiological and morphological changes in the organisms, but excessive training loads may induce damage and impair recovery or muscle growth. The purpose of the study was to evaluate the impact of Silymarin (SM) consumption on endurance capacity, muscle/cardiac histological changes, bodyweight, and food intake in rats subjected to 60 min of regular exercise training (RET) five days per week. (2) Methods: Male Wistar rats were subjected to an eight-week RET treadmill program and were previously administered SM and vitamin C. Bodyweight and food consumption were measured and registered. The maximal endurance capacity (MEC) test was performed at weeks one and eight. After the last training session, the animals were sacrificed, and samples of quadriceps/gastrocnemius and cardiac tissue were obtained and process for histological analyzes. (3) Results: SM consumption improved muscle recovery, inflammation, and damaged tissue, and promoted hypertrophy, vascularization, and muscle fiber shape/appearance. MEC increased after eight weeks of RET in all trained groups; moreover, the SM-treated group was enhanced more than the group with vitamin C. There were no significant changes in bodyweight and in food and nutrient consumption along the study. (5) Conclusion: SM supplementation may enhance physical performance, recovery, and muscle hypertrophy during the eight-week RET program.
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spelling pubmed-75900642020-10-29 Effect of Silymarin Supplementation on Physical Performance, Muscle and Myocardium Histological Changes, Bodyweight, and Food Consumption in Rats Subjected to Regular Exercise Training Vargas-Mendoza, Nancy Ángeles-Valencia, Marcelo Madrigal-Santillán, Eduardo Osiris Morales-Martínez, Mauricio Tirado-Lule, Judith Margarita Solano-Urrusquieta, Arturo Madrigal-Bujaidar, Eduardo Álvarez-González, Isela Fregoso-Aguilar, Tomás Morales-González, Ángel Morales-González, José A. Int J Mol Sci Article (1) Background: Regular exercise induces physiological and morphological changes in the organisms, but excessive training loads may induce damage and impair recovery or muscle growth. The purpose of the study was to evaluate the impact of Silymarin (SM) consumption on endurance capacity, muscle/cardiac histological changes, bodyweight, and food intake in rats subjected to 60 min of regular exercise training (RET) five days per week. (2) Methods: Male Wistar rats were subjected to an eight-week RET treadmill program and were previously administered SM and vitamin C. Bodyweight and food consumption were measured and registered. The maximal endurance capacity (MEC) test was performed at weeks one and eight. After the last training session, the animals were sacrificed, and samples of quadriceps/gastrocnemius and cardiac tissue were obtained and process for histological analyzes. (3) Results: SM consumption improved muscle recovery, inflammation, and damaged tissue, and promoted hypertrophy, vascularization, and muscle fiber shape/appearance. MEC increased after eight weeks of RET in all trained groups; moreover, the SM-treated group was enhanced more than the group with vitamin C. There were no significant changes in bodyweight and in food and nutrient consumption along the study. (5) Conclusion: SM supplementation may enhance physical performance, recovery, and muscle hypertrophy during the eight-week RET program. MDPI 2020-10-19 /pmc/articles/PMC7590064/ /pubmed/33086540 http://dx.doi.org/10.3390/ijms21207724 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Vargas-Mendoza, Nancy
Ángeles-Valencia, Marcelo
Madrigal-Santillán, Eduardo Osiris
Morales-Martínez, Mauricio
Tirado-Lule, Judith Margarita
Solano-Urrusquieta, Arturo
Madrigal-Bujaidar, Eduardo
Álvarez-González, Isela
Fregoso-Aguilar, Tomás
Morales-González, Ángel
Morales-González, José A.
Effect of Silymarin Supplementation on Physical Performance, Muscle and Myocardium Histological Changes, Bodyweight, and Food Consumption in Rats Subjected to Regular Exercise Training
title Effect of Silymarin Supplementation on Physical Performance, Muscle and Myocardium Histological Changes, Bodyweight, and Food Consumption in Rats Subjected to Regular Exercise Training
title_full Effect of Silymarin Supplementation on Physical Performance, Muscle and Myocardium Histological Changes, Bodyweight, and Food Consumption in Rats Subjected to Regular Exercise Training
title_fullStr Effect of Silymarin Supplementation on Physical Performance, Muscle and Myocardium Histological Changes, Bodyweight, and Food Consumption in Rats Subjected to Regular Exercise Training
title_full_unstemmed Effect of Silymarin Supplementation on Physical Performance, Muscle and Myocardium Histological Changes, Bodyweight, and Food Consumption in Rats Subjected to Regular Exercise Training
title_short Effect of Silymarin Supplementation on Physical Performance, Muscle and Myocardium Histological Changes, Bodyweight, and Food Consumption in Rats Subjected to Regular Exercise Training
title_sort effect of silymarin supplementation on physical performance, muscle and myocardium histological changes, bodyweight, and food consumption in rats subjected to regular exercise training
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7590064/
https://www.ncbi.nlm.nih.gov/pubmed/33086540
http://dx.doi.org/10.3390/ijms21207724
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