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Nanomedicine for Ischemic Stroke
Stroke is a severe brain disease leading to disability and death. Ischemic stroke dominates in stroke cases, and there are no effective therapies in clinic, partly due to the challenges in delivering therapeutics to ischemic sites in the brain. This review is focused on the current knowledge of path...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7590220/ https://www.ncbi.nlm.nih.gov/pubmed/33066616 http://dx.doi.org/10.3390/ijms21207600 |
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author | Dong, Xinyue Gao, Jin Su, Yujie Wang, Zhenjia |
author_facet | Dong, Xinyue Gao, Jin Su, Yujie Wang, Zhenjia |
author_sort | Dong, Xinyue |
collection | PubMed |
description | Stroke is a severe brain disease leading to disability and death. Ischemic stroke dominates in stroke cases, and there are no effective therapies in clinic, partly due to the challenges in delivering therapeutics to ischemic sites in the brain. This review is focused on the current knowledge of pathogenesis in ischemic stroke, and its potential therapies and diagnosis. Furthermore, we present recent advances in developments of nanoparticle-based therapeutics for improved treatment of ischemic stroke using polymeric NPs, liposomes and cell-derived nanovesicles. We also address several critical questions in ischemic stroke, such as understanding how nanoparticles cross the blood brain barrier and developing in vivo imaging technologies to address this critical question. Finally, we discuss new opportunities in developing novel therapeutics by targeting activated brain endothelium and inflammatory neutrophils to improve the current therapies for ischemic stroke. |
format | Online Article Text |
id | pubmed-7590220 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75902202020-10-29 Nanomedicine for Ischemic Stroke Dong, Xinyue Gao, Jin Su, Yujie Wang, Zhenjia Int J Mol Sci Review Stroke is a severe brain disease leading to disability and death. Ischemic stroke dominates in stroke cases, and there are no effective therapies in clinic, partly due to the challenges in delivering therapeutics to ischemic sites in the brain. This review is focused on the current knowledge of pathogenesis in ischemic stroke, and its potential therapies and diagnosis. Furthermore, we present recent advances in developments of nanoparticle-based therapeutics for improved treatment of ischemic stroke using polymeric NPs, liposomes and cell-derived nanovesicles. We also address several critical questions in ischemic stroke, such as understanding how nanoparticles cross the blood brain barrier and developing in vivo imaging technologies to address this critical question. Finally, we discuss new opportunities in developing novel therapeutics by targeting activated brain endothelium and inflammatory neutrophils to improve the current therapies for ischemic stroke. MDPI 2020-10-14 /pmc/articles/PMC7590220/ /pubmed/33066616 http://dx.doi.org/10.3390/ijms21207600 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Dong, Xinyue Gao, Jin Su, Yujie Wang, Zhenjia Nanomedicine for Ischemic Stroke |
title | Nanomedicine for Ischemic Stroke |
title_full | Nanomedicine for Ischemic Stroke |
title_fullStr | Nanomedicine for Ischemic Stroke |
title_full_unstemmed | Nanomedicine for Ischemic Stroke |
title_short | Nanomedicine for Ischemic Stroke |
title_sort | nanomedicine for ischemic stroke |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7590220/ https://www.ncbi.nlm.nih.gov/pubmed/33066616 http://dx.doi.org/10.3390/ijms21207600 |
work_keys_str_mv | AT dongxinyue nanomedicineforischemicstroke AT gaojin nanomedicineforischemicstroke AT suyujie nanomedicineforischemicstroke AT wangzhenjia nanomedicineforischemicstroke |