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Nanomedicine for Ischemic Stroke

Stroke is a severe brain disease leading to disability and death. Ischemic stroke dominates in stroke cases, and there are no effective therapies in clinic, partly due to the challenges in delivering therapeutics to ischemic sites in the brain. This review is focused on the current knowledge of path...

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Detalles Bibliográficos
Autores principales: Dong, Xinyue, Gao, Jin, Su, Yujie, Wang, Zhenjia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7590220/
https://www.ncbi.nlm.nih.gov/pubmed/33066616
http://dx.doi.org/10.3390/ijms21207600
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author Dong, Xinyue
Gao, Jin
Su, Yujie
Wang, Zhenjia
author_facet Dong, Xinyue
Gao, Jin
Su, Yujie
Wang, Zhenjia
author_sort Dong, Xinyue
collection PubMed
description Stroke is a severe brain disease leading to disability and death. Ischemic stroke dominates in stroke cases, and there are no effective therapies in clinic, partly due to the challenges in delivering therapeutics to ischemic sites in the brain. This review is focused on the current knowledge of pathogenesis in ischemic stroke, and its potential therapies and diagnosis. Furthermore, we present recent advances in developments of nanoparticle-based therapeutics for improved treatment of ischemic stroke using polymeric NPs, liposomes and cell-derived nanovesicles. We also address several critical questions in ischemic stroke, such as understanding how nanoparticles cross the blood brain barrier and developing in vivo imaging technologies to address this critical question. Finally, we discuss new opportunities in developing novel therapeutics by targeting activated brain endothelium and inflammatory neutrophils to improve the current therapies for ischemic stroke.
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spelling pubmed-75902202020-10-29 Nanomedicine for Ischemic Stroke Dong, Xinyue Gao, Jin Su, Yujie Wang, Zhenjia Int J Mol Sci Review Stroke is a severe brain disease leading to disability and death. Ischemic stroke dominates in stroke cases, and there are no effective therapies in clinic, partly due to the challenges in delivering therapeutics to ischemic sites in the brain. This review is focused on the current knowledge of pathogenesis in ischemic stroke, and its potential therapies and diagnosis. Furthermore, we present recent advances in developments of nanoparticle-based therapeutics for improved treatment of ischemic stroke using polymeric NPs, liposomes and cell-derived nanovesicles. We also address several critical questions in ischemic stroke, such as understanding how nanoparticles cross the blood brain barrier and developing in vivo imaging technologies to address this critical question. Finally, we discuss new opportunities in developing novel therapeutics by targeting activated brain endothelium and inflammatory neutrophils to improve the current therapies for ischemic stroke. MDPI 2020-10-14 /pmc/articles/PMC7590220/ /pubmed/33066616 http://dx.doi.org/10.3390/ijms21207600 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Dong, Xinyue
Gao, Jin
Su, Yujie
Wang, Zhenjia
Nanomedicine for Ischemic Stroke
title Nanomedicine for Ischemic Stroke
title_full Nanomedicine for Ischemic Stroke
title_fullStr Nanomedicine for Ischemic Stroke
title_full_unstemmed Nanomedicine for Ischemic Stroke
title_short Nanomedicine for Ischemic Stroke
title_sort nanomedicine for ischemic stroke
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7590220/
https://www.ncbi.nlm.nih.gov/pubmed/33066616
http://dx.doi.org/10.3390/ijms21207600
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