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High‐sugar diet intake, physical activity, and gut microbiota crosstalk: Implications for obesity in rats

This study aims to evaluate the effect of long‐term high‐sugar diet (HSD) intake and regular physical activity on gut microbiota as well as its health impact. Weaned male Wistar rats were fed with standard chow diet (SSD) or HSD ad libitum and subjected or not to regular swimming training with a wor...

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Autores principales: de Oliveira Neves, Viviano Gomes, de Oliveira, Daiane Teixeira, Oliveira, Deborah Campos, Oliveira Perucci, Luiza, dos Santos, Talita Adriana Pereira, da Costa Fernandes, Isabela, de Sousa, Graziele Galdino, Barboza, Natália Rocha, Guerra‐Sá, Renata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7590324/
https://www.ncbi.nlm.nih.gov/pubmed/33133570
http://dx.doi.org/10.1002/fsn3.1842
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author de Oliveira Neves, Viviano Gomes
de Oliveira, Daiane Teixeira
Oliveira, Deborah Campos
Oliveira Perucci, Luiza
dos Santos, Talita Adriana Pereira
da Costa Fernandes, Isabela
de Sousa, Graziele Galdino
Barboza, Natália Rocha
Guerra‐Sá, Renata
author_facet de Oliveira Neves, Viviano Gomes
de Oliveira, Daiane Teixeira
Oliveira, Deborah Campos
Oliveira Perucci, Luiza
dos Santos, Talita Adriana Pereira
da Costa Fernandes, Isabela
de Sousa, Graziele Galdino
Barboza, Natália Rocha
Guerra‐Sá, Renata
author_sort de Oliveira Neves, Viviano Gomes
collection PubMed
description This study aims to evaluate the effect of long‐term high‐sugar diet (HSD) intake and regular physical activity on gut microbiota as well as its health impact. Weaned male Wistar rats were fed with standard chow diet (SSD) or HSD ad libitum and subjected or not to regular swimming training with a workload (2% of body weight) for 15 weeks. Feces samples were used on microbiome analysis using 16S rRNA amplicon sequencing. HSD increased body mass, adipose cushions, and the serum levels of triglycerides and VLDL, also changed the bacteria taxons associated with metabolic disorders (increase taxons belonging to Proteobacteria phylum and decrease Pediococcus genus); the swim training reverted these changes. SSD intake increased the abundance of bacteria associated with metabolization of dietary fiber. Training in association with SSD consumption beneficially modulated the microbiota, increasing the Bacteroidetes, Bacteroidaceae, Porphyromonadaceae, Parabacteroides, and Lactobacillaceae, and decreasing the Firmicute/Bacteroidetes ratio; training was not able to maintain this profile in animals SHD‐fed. Physical training modulates the gut microbiota reversing the obesogenic response caused by SHD. However, training itself is not efficient for up‐regulating the probiotic bacteria in comparison to its association with a balanced diet.
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spelling pubmed-75903242020-10-30 High‐sugar diet intake, physical activity, and gut microbiota crosstalk: Implications for obesity in rats de Oliveira Neves, Viviano Gomes de Oliveira, Daiane Teixeira Oliveira, Deborah Campos Oliveira Perucci, Luiza dos Santos, Talita Adriana Pereira da Costa Fernandes, Isabela de Sousa, Graziele Galdino Barboza, Natália Rocha Guerra‐Sá, Renata Food Sci Nutr Original Research This study aims to evaluate the effect of long‐term high‐sugar diet (HSD) intake and regular physical activity on gut microbiota as well as its health impact. Weaned male Wistar rats were fed with standard chow diet (SSD) or HSD ad libitum and subjected or not to regular swimming training with a workload (2% of body weight) for 15 weeks. Feces samples were used on microbiome analysis using 16S rRNA amplicon sequencing. HSD increased body mass, adipose cushions, and the serum levels of triglycerides and VLDL, also changed the bacteria taxons associated with metabolic disorders (increase taxons belonging to Proteobacteria phylum and decrease Pediococcus genus); the swim training reverted these changes. SSD intake increased the abundance of bacteria associated with metabolization of dietary fiber. Training in association with SSD consumption beneficially modulated the microbiota, increasing the Bacteroidetes, Bacteroidaceae, Porphyromonadaceae, Parabacteroides, and Lactobacillaceae, and decreasing the Firmicute/Bacteroidetes ratio; training was not able to maintain this profile in animals SHD‐fed. Physical training modulates the gut microbiota reversing the obesogenic response caused by SHD. However, training itself is not efficient for up‐regulating the probiotic bacteria in comparison to its association with a balanced diet. John Wiley and Sons Inc. 2020-09-09 /pmc/articles/PMC7590324/ /pubmed/33133570 http://dx.doi.org/10.1002/fsn3.1842 Text en © 2020 The Authors. Food Science & Nutrition published by Wiley Periodicals LLC. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
de Oliveira Neves, Viviano Gomes
de Oliveira, Daiane Teixeira
Oliveira, Deborah Campos
Oliveira Perucci, Luiza
dos Santos, Talita Adriana Pereira
da Costa Fernandes, Isabela
de Sousa, Graziele Galdino
Barboza, Natália Rocha
Guerra‐Sá, Renata
High‐sugar diet intake, physical activity, and gut microbiota crosstalk: Implications for obesity in rats
title High‐sugar diet intake, physical activity, and gut microbiota crosstalk: Implications for obesity in rats
title_full High‐sugar diet intake, physical activity, and gut microbiota crosstalk: Implications for obesity in rats
title_fullStr High‐sugar diet intake, physical activity, and gut microbiota crosstalk: Implications for obesity in rats
title_full_unstemmed High‐sugar diet intake, physical activity, and gut microbiota crosstalk: Implications for obesity in rats
title_short High‐sugar diet intake, physical activity, and gut microbiota crosstalk: Implications for obesity in rats
title_sort high‐sugar diet intake, physical activity, and gut microbiota crosstalk: implications for obesity in rats
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7590324/
https://www.ncbi.nlm.nih.gov/pubmed/33133570
http://dx.doi.org/10.1002/fsn3.1842
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