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Left ventricular thrombus and pulmonary embolism: A case series of thrombosis in COVID‐19 in Thai patients

Thrombosis in COVID‐19 is increasingly recognized and is generally associated with a high mortality rate. The key clinical question of this report was whether COVID‐19 could be complicated with cardiac thrombus and pulmonary embolism in Asian population. We demonstrated the case series of thrombosis...

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Autores principales: Nanthatanti, Nithita, Phusanti, Sithakom, Chantrathammachart, Pichika, Thammavaranucupt, Kanin, Angchaisuksiri, Pantep, Sungkanuparph, Somnuek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7590338/
https://www.ncbi.nlm.nih.gov/pubmed/33134788
http://dx.doi.org/10.1002/rth2.12435
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author Nanthatanti, Nithita
Phusanti, Sithakom
Chantrathammachart, Pichika
Thammavaranucupt, Kanin
Angchaisuksiri, Pantep
Sungkanuparph, Somnuek
author_facet Nanthatanti, Nithita
Phusanti, Sithakom
Chantrathammachart, Pichika
Thammavaranucupt, Kanin
Angchaisuksiri, Pantep
Sungkanuparph, Somnuek
author_sort Nanthatanti, Nithita
collection PubMed
description Thrombosis in COVID‐19 is increasingly recognized and is generally associated with a high mortality rate. The key clinical question of this report was whether COVID‐19 could be complicated with cardiac thrombus and pulmonary embolism in Asian population. We demonstrated the case series of thrombosis in Thai patients with confirmed severe acute respiratory syndrome coronavirus 2 infection. One patient had the first case of a large left ventricular thrombus, and three other patients had pulmonary embolism. All patients were male and had low absolute lymphocyte count, while lactate dehydrogenase level and d‐dimer were markedly elevated, especially at the time when the thrombosis was diagnosed. All patients had severe COVID‐19 with pneumonia. Two patients who needed mechanical ventilation were successfully extubated. After hospitalization for 13‐49 days, pneumonia and thrombosis improved and all of them could be discharged from the hospital. Thrombosis is common in COVID‐19 and could present in both arterial and venous sites even in Asian populations. d‐dimer is a strong marker to predict thrombosis and could be a prognostic predictor for severity of COVID‐19.
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spelling pubmed-75903382020-10-30 Left ventricular thrombus and pulmonary embolism: A case series of thrombosis in COVID‐19 in Thai patients Nanthatanti, Nithita Phusanti, Sithakom Chantrathammachart, Pichika Thammavaranucupt, Kanin Angchaisuksiri, Pantep Sungkanuparph, Somnuek Res Pract Thromb Haemost Case Report Thrombosis in COVID‐19 is increasingly recognized and is generally associated with a high mortality rate. The key clinical question of this report was whether COVID‐19 could be complicated with cardiac thrombus and pulmonary embolism in Asian population. We demonstrated the case series of thrombosis in Thai patients with confirmed severe acute respiratory syndrome coronavirus 2 infection. One patient had the first case of a large left ventricular thrombus, and three other patients had pulmonary embolism. All patients were male and had low absolute lymphocyte count, while lactate dehydrogenase level and d‐dimer were markedly elevated, especially at the time when the thrombosis was diagnosed. All patients had severe COVID‐19 with pneumonia. Two patients who needed mechanical ventilation were successfully extubated. After hospitalization for 13‐49 days, pneumonia and thrombosis improved and all of them could be discharged from the hospital. Thrombosis is common in COVID‐19 and could present in both arterial and venous sites even in Asian populations. d‐dimer is a strong marker to predict thrombosis and could be a prognostic predictor for severity of COVID‐19. John Wiley and Sons Inc. 2020-10-13 /pmc/articles/PMC7590338/ /pubmed/33134788 http://dx.doi.org/10.1002/rth2.12435 Text en © 2020 The Authors. Research and Practice in Thrombosis and Haemostasis published by Wiley Periodicals LLC on behalf of International Society on Thrombosis and Haemostasis (ISTH). This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Case Report
Nanthatanti, Nithita
Phusanti, Sithakom
Chantrathammachart, Pichika
Thammavaranucupt, Kanin
Angchaisuksiri, Pantep
Sungkanuparph, Somnuek
Left ventricular thrombus and pulmonary embolism: A case series of thrombosis in COVID‐19 in Thai patients
title Left ventricular thrombus and pulmonary embolism: A case series of thrombosis in COVID‐19 in Thai patients
title_full Left ventricular thrombus and pulmonary embolism: A case series of thrombosis in COVID‐19 in Thai patients
title_fullStr Left ventricular thrombus and pulmonary embolism: A case series of thrombosis in COVID‐19 in Thai patients
title_full_unstemmed Left ventricular thrombus and pulmonary embolism: A case series of thrombosis in COVID‐19 in Thai patients
title_short Left ventricular thrombus and pulmonary embolism: A case series of thrombosis in COVID‐19 in Thai patients
title_sort left ventricular thrombus and pulmonary embolism: a case series of thrombosis in covid‐19 in thai patients
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7590338/
https://www.ncbi.nlm.nih.gov/pubmed/33134788
http://dx.doi.org/10.1002/rth2.12435
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