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Left ventricular thrombus and pulmonary embolism: A case series of thrombosis in COVID‐19 in Thai patients
Thrombosis in COVID‐19 is increasingly recognized and is generally associated with a high mortality rate. The key clinical question of this report was whether COVID‐19 could be complicated with cardiac thrombus and pulmonary embolism in Asian population. We demonstrated the case series of thrombosis...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7590338/ https://www.ncbi.nlm.nih.gov/pubmed/33134788 http://dx.doi.org/10.1002/rth2.12435 |
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author | Nanthatanti, Nithita Phusanti, Sithakom Chantrathammachart, Pichika Thammavaranucupt, Kanin Angchaisuksiri, Pantep Sungkanuparph, Somnuek |
author_facet | Nanthatanti, Nithita Phusanti, Sithakom Chantrathammachart, Pichika Thammavaranucupt, Kanin Angchaisuksiri, Pantep Sungkanuparph, Somnuek |
author_sort | Nanthatanti, Nithita |
collection | PubMed |
description | Thrombosis in COVID‐19 is increasingly recognized and is generally associated with a high mortality rate. The key clinical question of this report was whether COVID‐19 could be complicated with cardiac thrombus and pulmonary embolism in Asian population. We demonstrated the case series of thrombosis in Thai patients with confirmed severe acute respiratory syndrome coronavirus 2 infection. One patient had the first case of a large left ventricular thrombus, and three other patients had pulmonary embolism. All patients were male and had low absolute lymphocyte count, while lactate dehydrogenase level and d‐dimer were markedly elevated, especially at the time when the thrombosis was diagnosed. All patients had severe COVID‐19 with pneumonia. Two patients who needed mechanical ventilation were successfully extubated. After hospitalization for 13‐49 days, pneumonia and thrombosis improved and all of them could be discharged from the hospital. Thrombosis is common in COVID‐19 and could present in both arterial and venous sites even in Asian populations. d‐dimer is a strong marker to predict thrombosis and could be a prognostic predictor for severity of COVID‐19. |
format | Online Article Text |
id | pubmed-7590338 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-75903382020-10-30 Left ventricular thrombus and pulmonary embolism: A case series of thrombosis in COVID‐19 in Thai patients Nanthatanti, Nithita Phusanti, Sithakom Chantrathammachart, Pichika Thammavaranucupt, Kanin Angchaisuksiri, Pantep Sungkanuparph, Somnuek Res Pract Thromb Haemost Case Report Thrombosis in COVID‐19 is increasingly recognized and is generally associated with a high mortality rate. The key clinical question of this report was whether COVID‐19 could be complicated with cardiac thrombus and pulmonary embolism in Asian population. We demonstrated the case series of thrombosis in Thai patients with confirmed severe acute respiratory syndrome coronavirus 2 infection. One patient had the first case of a large left ventricular thrombus, and three other patients had pulmonary embolism. All patients were male and had low absolute lymphocyte count, while lactate dehydrogenase level and d‐dimer were markedly elevated, especially at the time when the thrombosis was diagnosed. All patients had severe COVID‐19 with pneumonia. Two patients who needed mechanical ventilation were successfully extubated. After hospitalization for 13‐49 days, pneumonia and thrombosis improved and all of them could be discharged from the hospital. Thrombosis is common in COVID‐19 and could present in both arterial and venous sites even in Asian populations. d‐dimer is a strong marker to predict thrombosis and could be a prognostic predictor for severity of COVID‐19. John Wiley and Sons Inc. 2020-10-13 /pmc/articles/PMC7590338/ /pubmed/33134788 http://dx.doi.org/10.1002/rth2.12435 Text en © 2020 The Authors. Research and Practice in Thrombosis and Haemostasis published by Wiley Periodicals LLC on behalf of International Society on Thrombosis and Haemostasis (ISTH). This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Case Report Nanthatanti, Nithita Phusanti, Sithakom Chantrathammachart, Pichika Thammavaranucupt, Kanin Angchaisuksiri, Pantep Sungkanuparph, Somnuek Left ventricular thrombus and pulmonary embolism: A case series of thrombosis in COVID‐19 in Thai patients |
title | Left ventricular thrombus and pulmonary embolism: A case series of thrombosis in COVID‐19 in Thai patients |
title_full | Left ventricular thrombus and pulmonary embolism: A case series of thrombosis in COVID‐19 in Thai patients |
title_fullStr | Left ventricular thrombus and pulmonary embolism: A case series of thrombosis in COVID‐19 in Thai patients |
title_full_unstemmed | Left ventricular thrombus and pulmonary embolism: A case series of thrombosis in COVID‐19 in Thai patients |
title_short | Left ventricular thrombus and pulmonary embolism: A case series of thrombosis in COVID‐19 in Thai patients |
title_sort | left ventricular thrombus and pulmonary embolism: a case series of thrombosis in covid‐19 in thai patients |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7590338/ https://www.ncbi.nlm.nih.gov/pubmed/33134788 http://dx.doi.org/10.1002/rth2.12435 |
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