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Distinct integrin activation pathways for effector and regulatory T cell trafficking and function

Integrin activation mediates lymphocyte trafficking and immune functions. Conventional T cell (Tconv cell) integrin activation requires Rap1-interacting adaptor molecule (RIAM). Here, we report that Apbb1ip(−/−) (RIAM-null) mice are protected from spontaneous colitis due to IL-10 deficiency, a model...

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Detalles Bibliográficos
Autores principales:	Sun, Hao, Lagarrigue, Frederic, Wang, Hsin, Fan, Zhichao, Lopez-Ramirez, Miguel Alejandro, Chang, John T., Ginsberg, Mark H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7590511/ https://www.ncbi.nlm.nih.gov/pubmed/33104169 http://dx.doi.org/10.1084/jem.20201524

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