Lysosomal cathepsin creates chimeric epitopes for diabetogenic CD4 T cells via transpeptidation

The identification of the peptide epitopes presented by major histocompatibility complex class II (MHCII) molecules that drive the CD4 T cell component of autoimmune diseases has presented a formidable challenge over several decades. In type 1 diabetes (T1D), recent insight into this problem has com...

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Detalles Bibliográficos
Autores principales: Reed, Brendan, Crawford, Frances, Hill, Ryan C., Jin, Niyun, White, Janice, Krovi, S. Harsha, Marrack, Philippa, Hansen, Kirk, Kappler, John W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7590512/
https://www.ncbi.nlm.nih.gov/pubmed/33095259
http://dx.doi.org/10.1084/jem.20192135

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7590512/
https://www.ncbi.nlm.nih.gov/pubmed/33095259
http://dx.doi.org/10.1084/jem.20192135

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