Cargando…
Serum Levels of Gamma-Glutamyltransferase During Stable and Acute Exacerbations of Chronic Obstructive Pulmonary Disease
BACKGROUND: One of the most important factors in the pathogenesis of COPD (chronic obstructive pulmonary disease) is oxidative stress. GGT (gamma-glutamyltransferase) has been regarded as a novel marker of oxidative stress over the last few years. This study aimed to compare the serum levels of GGT...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scientific Literature, Inc.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7590526/ https://www.ncbi.nlm.nih.gov/pubmed/33087693 http://dx.doi.org/10.12659/MSM.927771 |
_version_ | 1783600819407421440 |
---|---|
author | Sun, Desheng Liu, Hongyan Ouyang, Yao Liu, Xiansheng Xu, Yongjian |
author_facet | Sun, Desheng Liu, Hongyan Ouyang, Yao Liu, Xiansheng Xu, Yongjian |
author_sort | Sun, Desheng |
collection | PubMed |
description | BACKGROUND: One of the most important factors in the pathogenesis of COPD (chronic obstructive pulmonary disease) is oxidative stress. GGT (gamma-glutamyltransferase) has been regarded as a novel marker of oxidative stress over the last few years. This study aimed to compare the serum levels of GGT during stable and acute exacerbations of COPD at a single center. MATERIAL/METHODS: The research included 117 patients with AECOPD (acute exacerbation of chronic obstructive pulmonary disease), 107 patients with stable COPD, and 112 control subjects. Serum GGT, spirometry function, and other clinical parameters (anthropometric and biochemical measurements) were evaluated and compared among the subjects. RESULTS: Serum GGT was elevated in patients with stable COPD in comparison to the control subjects. Its level was inversely related to lung function. It was also significantly higher in AECOPD patients compared to stable COPD patients. We also found that a GGT level of 21.2 IU/L displays a reliable diagnostic prediction of COPD and that a GGT level of 26.5 IU/L can be applied to predict the exacerbation of COPD. CONCLUSIONS: Our research demonstrates that serum GGT level is inversely associated with pulmonary function and may serve as a biomarker during the progression of COPD. The monitoring of GGT values can be applied to evaluating COPD and its exacerbation risk. |
format | Online Article Text |
id | pubmed-7590526 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | International Scientific Literature, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-75905262020-10-28 Serum Levels of Gamma-Glutamyltransferase During Stable and Acute Exacerbations of Chronic Obstructive Pulmonary Disease Sun, Desheng Liu, Hongyan Ouyang, Yao Liu, Xiansheng Xu, Yongjian Med Sci Monit Clinical Research BACKGROUND: One of the most important factors in the pathogenesis of COPD (chronic obstructive pulmonary disease) is oxidative stress. GGT (gamma-glutamyltransferase) has been regarded as a novel marker of oxidative stress over the last few years. This study aimed to compare the serum levels of GGT during stable and acute exacerbations of COPD at a single center. MATERIAL/METHODS: The research included 117 patients with AECOPD (acute exacerbation of chronic obstructive pulmonary disease), 107 patients with stable COPD, and 112 control subjects. Serum GGT, spirometry function, and other clinical parameters (anthropometric and biochemical measurements) were evaluated and compared among the subjects. RESULTS: Serum GGT was elevated in patients with stable COPD in comparison to the control subjects. Its level was inversely related to lung function. It was also significantly higher in AECOPD patients compared to stable COPD patients. We also found that a GGT level of 21.2 IU/L displays a reliable diagnostic prediction of COPD and that a GGT level of 26.5 IU/L can be applied to predict the exacerbation of COPD. CONCLUSIONS: Our research demonstrates that serum GGT level is inversely associated with pulmonary function and may serve as a biomarker during the progression of COPD. The monitoring of GGT values can be applied to evaluating COPD and its exacerbation risk. International Scientific Literature, Inc. 2020-10-22 /pmc/articles/PMC7590526/ /pubmed/33087693 http://dx.doi.org/10.12659/MSM.927771 Text en © Med Sci Monit, 2020 This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) ) |
spellingShingle | Clinical Research Sun, Desheng Liu, Hongyan Ouyang, Yao Liu, Xiansheng Xu, Yongjian Serum Levels of Gamma-Glutamyltransferase During Stable and Acute Exacerbations of Chronic Obstructive Pulmonary Disease |
title | Serum Levels of Gamma-Glutamyltransferase During Stable and Acute Exacerbations of Chronic Obstructive Pulmonary Disease |
title_full | Serum Levels of Gamma-Glutamyltransferase During Stable and Acute Exacerbations of Chronic Obstructive Pulmonary Disease |
title_fullStr | Serum Levels of Gamma-Glutamyltransferase During Stable and Acute Exacerbations of Chronic Obstructive Pulmonary Disease |
title_full_unstemmed | Serum Levels of Gamma-Glutamyltransferase During Stable and Acute Exacerbations of Chronic Obstructive Pulmonary Disease |
title_short | Serum Levels of Gamma-Glutamyltransferase During Stable and Acute Exacerbations of Chronic Obstructive Pulmonary Disease |
title_sort | serum levels of gamma-glutamyltransferase during stable and acute exacerbations of chronic obstructive pulmonary disease |
topic | Clinical Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7590526/ https://www.ncbi.nlm.nih.gov/pubmed/33087693 http://dx.doi.org/10.12659/MSM.927771 |
work_keys_str_mv | AT sundesheng serumlevelsofgammaglutamyltransferaseduringstableandacuteexacerbationsofchronicobstructivepulmonarydisease AT liuhongyan serumlevelsofgammaglutamyltransferaseduringstableandacuteexacerbationsofchronicobstructivepulmonarydisease AT ouyangyao serumlevelsofgammaglutamyltransferaseduringstableandacuteexacerbationsofchronicobstructivepulmonarydisease AT liuxiansheng serumlevelsofgammaglutamyltransferaseduringstableandacuteexacerbationsofchronicobstructivepulmonarydisease AT xuyongjian serumlevelsofgammaglutamyltransferaseduringstableandacuteexacerbationsofchronicobstructivepulmonarydisease |