PIWI-interacting RNAs and PIWI proteins in glioma: molecular pathogenesis and role as biomarkers

Glioma is the most common primary brain tumor, and is a major health problem throughout the world. Today, researchers have discovered many risk factors that are associated with the initiation and progression of gliomas. Studies have shown that PIWI-interacting RNAs (piRNAs) and PIWI proteins are inv...

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Autores principales: Tamtaji, Omid Reza, Behnam, Mohammad, Pourattar, Mohammad Ali, Hamblin, Michael R., Mahjoubin-Tehran, Maryam, Mirzaei, Hamed, Asemi, Zatollah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7590611/
https://www.ncbi.nlm.nih.gov/pubmed/33109195
http://dx.doi.org/10.1186/s12964-020-00657-z
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author Tamtaji, Omid Reza
Behnam, Mohammad
Pourattar, Mohammad Ali
Hamblin, Michael R.
Mahjoubin-Tehran, Maryam
Mirzaei, Hamed
Asemi, Zatollah
author_facet Tamtaji, Omid Reza
Behnam, Mohammad
Pourattar, Mohammad Ali
Hamblin, Michael R.
Mahjoubin-Tehran, Maryam
Mirzaei, Hamed
Asemi, Zatollah
author_sort Tamtaji, Omid Reza
collection PubMed
description Glioma is the most common primary brain tumor, and is a major health problem throughout the world. Today, researchers have discovered many risk factors that are associated with the initiation and progression of gliomas. Studies have shown that PIWI-interacting RNAs (piRNAs) and PIWI proteins are involved in tumorigenesis by epigenetic mechanisms. Hence, it seems that piRNAs and PIWI proteins may be potential prognostic, diagnostic or therapeutic biomarkers in the treatment of glioma. Previous studies have demonstrated a relationship between piRNAs and PIWI proteins and some of the molecular and cellular pathways in glioma. Here, we summarize recent evidence and evaluate the molecular mechanisms by which piRNAs and PIWI proteins are involved in glioma.
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spelling pubmed-75906112020-10-27 PIWI-interacting RNAs and PIWI proteins in glioma: molecular pathogenesis and role as biomarkers Tamtaji, Omid Reza Behnam, Mohammad Pourattar, Mohammad Ali Hamblin, Michael R. Mahjoubin-Tehran, Maryam Mirzaei, Hamed Asemi, Zatollah Cell Commun Signal Review Glioma is the most common primary brain tumor, and is a major health problem throughout the world. Today, researchers have discovered many risk factors that are associated with the initiation and progression of gliomas. Studies have shown that PIWI-interacting RNAs (piRNAs) and PIWI proteins are involved in tumorigenesis by epigenetic mechanisms. Hence, it seems that piRNAs and PIWI proteins may be potential prognostic, diagnostic or therapeutic biomarkers in the treatment of glioma. Previous studies have demonstrated a relationship between piRNAs and PIWI proteins and some of the molecular and cellular pathways in glioma. Here, we summarize recent evidence and evaluate the molecular mechanisms by which piRNAs and PIWI proteins are involved in glioma. BioMed Central 2020-10-27 /pmc/articles/PMC7590611/ /pubmed/33109195 http://dx.doi.org/10.1186/s12964-020-00657-z Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Tamtaji, Omid Reza
Behnam, Mohammad
Pourattar, Mohammad Ali
Hamblin, Michael R.
Mahjoubin-Tehran, Maryam
Mirzaei, Hamed
Asemi, Zatollah
PIWI-interacting RNAs and PIWI proteins in glioma: molecular pathogenesis and role as biomarkers
title PIWI-interacting RNAs and PIWI proteins in glioma: molecular pathogenesis and role as biomarkers
title_full PIWI-interacting RNAs and PIWI proteins in glioma: molecular pathogenesis and role as biomarkers
title_fullStr PIWI-interacting RNAs and PIWI proteins in glioma: molecular pathogenesis and role as biomarkers
title_full_unstemmed PIWI-interacting RNAs and PIWI proteins in glioma: molecular pathogenesis and role as biomarkers
title_short PIWI-interacting RNAs and PIWI proteins in glioma: molecular pathogenesis and role as biomarkers
title_sort piwi-interacting rnas and piwi proteins in glioma: molecular pathogenesis and role as biomarkers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7590611/
https://www.ncbi.nlm.nih.gov/pubmed/33109195
http://dx.doi.org/10.1186/s12964-020-00657-z
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