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Polygonum minus essential oil modulates cisplatin-induced hepatotoxicity through inflammatory and apoptotic pathways

Oxidative stress, inflammation and apoptosis are thought as primary mediators of cisplatin-induced hepatotoxicity. The objective of this study was to determine the protective effect of Polygonum minus essential oil in cisplatin-induced hepatotoxicity. A total of forty-two male rats were randomly div...

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Autores principales: Abd Rashid, Norhashima, Hussan, Farida, Hamid, Asmah, Adib Ridzuan, Nurul Raudzah, Halim, Syarifah Aisyah Syed Abd, Abdul Jalil, Nahdia Afiifah, Najib, Nor Haliza Mohamad, Teoh, Seong Lin, Budin, Siti Balkis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Leibniz Research Centre for Working Environment and Human Factors 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7590832/
https://www.ncbi.nlm.nih.gov/pubmed/33122975
http://dx.doi.org/10.17179/excli2020-2355
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author Abd Rashid, Norhashima
Hussan, Farida
Hamid, Asmah
Adib Ridzuan, Nurul Raudzah
Halim, Syarifah Aisyah Syed Abd
Abdul Jalil, Nahdia Afiifah
Najib, Nor Haliza Mohamad
Teoh, Seong Lin
Budin, Siti Balkis
author_facet Abd Rashid, Norhashima
Hussan, Farida
Hamid, Asmah
Adib Ridzuan, Nurul Raudzah
Halim, Syarifah Aisyah Syed Abd
Abdul Jalil, Nahdia Afiifah
Najib, Nor Haliza Mohamad
Teoh, Seong Lin
Budin, Siti Balkis
author_sort Abd Rashid, Norhashima
collection PubMed
description Oxidative stress, inflammation and apoptosis are thought as primary mediators of cisplatin-induced hepatotoxicity. The objective of this study was to determine the protective effect of Polygonum minus essential oil in cisplatin-induced hepatotoxicity. A total of forty-two male rats were randomly divided into seven groups: control, cisplatin, β-caryophyllene 150 mg/kg (BCP), PmEO 100 mg/kg + cisplatin (PmEO100CP), PmEO 200 mg/kg + cisplatin (PmEO200CP), PmEO 400 mg/kg + cisplatin (PmEO400CP) and PmEO 400 mg/kg (PmEO400). Rats in the BCP, PmEO100CP, PmEO200CP, PmEO400CP and PmEO400 group received respective treatment orally for 14 consecutive days prior to cisplatin injection. All animals except for those in the control group and PmEO400 were administered with a single dose of cisplatin (10 mg/kg) intraperitoneally on day 15 and all animals were sacrificed on day 18. PmEO100CP pretreatment protected against cisplatin-induced hepatotoxicity by decreasing CYP2E1 and indicators of oxidative stress including malondialdehyde, 8-OHdG and protein carbonyl which was accompanied by increased antioxidant status (glutathione, glutathione peroxidase, superoxide dismutase and catalase) as compared to cisplatin group. PmEO100CP pretreatment also modulated changes in liver inflammatory markers (TNF-α, IL-1α, IL-1β, IL-6 and IL-10). PmEO100CP administration also notably reduced cisplatin-induced apoptosis significantly as compared to cisplatin group. In conclusion, our results suggested that P. minus essential oil at a dose of 100 mg/kg may protect against cisplatin-induced hepatotoxicity possibly via inhibition of oxidative stress, inflammation and apoptosis.
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spelling pubmed-75908322020-10-28 Polygonum minus essential oil modulates cisplatin-induced hepatotoxicity through inflammatory and apoptotic pathways Abd Rashid, Norhashima Hussan, Farida Hamid, Asmah Adib Ridzuan, Nurul Raudzah Halim, Syarifah Aisyah Syed Abd Abdul Jalil, Nahdia Afiifah Najib, Nor Haliza Mohamad Teoh, Seong Lin Budin, Siti Balkis EXCLI J Original Article Oxidative stress, inflammation and apoptosis are thought as primary mediators of cisplatin-induced hepatotoxicity. The objective of this study was to determine the protective effect of Polygonum minus essential oil in cisplatin-induced hepatotoxicity. A total of forty-two male rats were randomly divided into seven groups: control, cisplatin, β-caryophyllene 150 mg/kg (BCP), PmEO 100 mg/kg + cisplatin (PmEO100CP), PmEO 200 mg/kg + cisplatin (PmEO200CP), PmEO 400 mg/kg + cisplatin (PmEO400CP) and PmEO 400 mg/kg (PmEO400). Rats in the BCP, PmEO100CP, PmEO200CP, PmEO400CP and PmEO400 group received respective treatment orally for 14 consecutive days prior to cisplatin injection. All animals except for those in the control group and PmEO400 were administered with a single dose of cisplatin (10 mg/kg) intraperitoneally on day 15 and all animals were sacrificed on day 18. PmEO100CP pretreatment protected against cisplatin-induced hepatotoxicity by decreasing CYP2E1 and indicators of oxidative stress including malondialdehyde, 8-OHdG and protein carbonyl which was accompanied by increased antioxidant status (glutathione, glutathione peroxidase, superoxide dismutase and catalase) as compared to cisplatin group. PmEO100CP pretreatment also modulated changes in liver inflammatory markers (TNF-α, IL-1α, IL-1β, IL-6 and IL-10). PmEO100CP administration also notably reduced cisplatin-induced apoptosis significantly as compared to cisplatin group. In conclusion, our results suggested that P. minus essential oil at a dose of 100 mg/kg may protect against cisplatin-induced hepatotoxicity possibly via inhibition of oxidative stress, inflammation and apoptosis. Leibniz Research Centre for Working Environment and Human Factors 2020-09-09 /pmc/articles/PMC7590832/ /pubmed/33122975 http://dx.doi.org/10.17179/excli2020-2355 Text en Copyright © 2020 Abd Rashid et al. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (http://creativecommons.org/licenses/by/4.0/) You are free to copy, distribute and transmit the work, provided the original author and source are credited.
spellingShingle Original Article
Abd Rashid, Norhashima
Hussan, Farida
Hamid, Asmah
Adib Ridzuan, Nurul Raudzah
Halim, Syarifah Aisyah Syed Abd
Abdul Jalil, Nahdia Afiifah
Najib, Nor Haliza Mohamad
Teoh, Seong Lin
Budin, Siti Balkis
Polygonum minus essential oil modulates cisplatin-induced hepatotoxicity through inflammatory and apoptotic pathways
title Polygonum minus essential oil modulates cisplatin-induced hepatotoxicity through inflammatory and apoptotic pathways
title_full Polygonum minus essential oil modulates cisplatin-induced hepatotoxicity through inflammatory and apoptotic pathways
title_fullStr Polygonum minus essential oil modulates cisplatin-induced hepatotoxicity through inflammatory and apoptotic pathways
title_full_unstemmed Polygonum minus essential oil modulates cisplatin-induced hepatotoxicity through inflammatory and apoptotic pathways
title_short Polygonum minus essential oil modulates cisplatin-induced hepatotoxicity through inflammatory and apoptotic pathways
title_sort polygonum minus essential oil modulates cisplatin-induced hepatotoxicity through inflammatory and apoptotic pathways
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7590832/
https://www.ncbi.nlm.nih.gov/pubmed/33122975
http://dx.doi.org/10.17179/excli2020-2355
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