Low Adherence Achieves High HCV Cure Rates Among People Who Inject Drugs Treated With Direct-Acting Antiviral Agents

We measured hepatitis C virus (HCV) adherence via electronic blister packs for 145 people who inject drugs treated on-site in a methadone program. The overall sustained virologic response (SVR) rate was 96% (95% CI, 91%–98%), and overall daily adherence was 78% (95% CI, 76%–81%). Participants who ac...

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Autores principales: Norton, Brianna L, Akiyama, Matthew J, Agyemang, Linda, Heo, Moonseong, Pericot-Valverde, Irene-, Litwin, Alain H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7590860/
https://www.ncbi.nlm.nih.gov/pubmed/33134406
http://dx.doi.org/10.1093/ofid/ofaa377
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author Norton, Brianna L
Akiyama, Matthew J
Agyemang, Linda
Heo, Moonseong
Pericot-Valverde, Irene-
Litwin, Alain H
author_facet Norton, Brianna L
Akiyama, Matthew J
Agyemang, Linda
Heo, Moonseong
Pericot-Valverde, Irene-
Litwin, Alain H
author_sort Norton, Brianna L
collection PubMed
description We measured hepatitis C virus (HCV) adherence via electronic blister packs for 145 people who inject drugs treated on-site in a methadone program. The overall sustained virologic response (SVR) rate was 96% (95% CI, 91%–98%), and overall daily adherence was 78% (95% CI, 76%–81%). Participants who achieved at least 50% adherence had an overall SVR rate of 99%, with each 5% adherence interval >50% achieving at least 90% adherence. Suboptimal adherence may still lead to cure in the direct-acting antiviral era.
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spelling pubmed-75908602020-10-30 Low Adherence Achieves High HCV Cure Rates Among People Who Inject Drugs Treated With Direct-Acting Antiviral Agents Norton, Brianna L Akiyama, Matthew J Agyemang, Linda Heo, Moonseong Pericot-Valverde, Irene- Litwin, Alain H Open Forum Infect Dis Brief Reports We measured hepatitis C virus (HCV) adherence via electronic blister packs for 145 people who inject drugs treated on-site in a methadone program. The overall sustained virologic response (SVR) rate was 96% (95% CI, 91%–98%), and overall daily adherence was 78% (95% CI, 76%–81%). Participants who achieved at least 50% adherence had an overall SVR rate of 99%, with each 5% adherence interval >50% achieving at least 90% adherence. Suboptimal adherence may still lead to cure in the direct-acting antiviral era. Oxford University Press 2020-08-26 /pmc/articles/PMC7590860/ /pubmed/33134406 http://dx.doi.org/10.1093/ofid/ofaa377 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Reports
Norton, Brianna L
Akiyama, Matthew J
Agyemang, Linda
Heo, Moonseong
Pericot-Valverde, Irene-
Litwin, Alain H
Low Adherence Achieves High HCV Cure Rates Among People Who Inject Drugs Treated With Direct-Acting Antiviral Agents
title Low Adherence Achieves High HCV Cure Rates Among People Who Inject Drugs Treated With Direct-Acting Antiviral Agents
title_full Low Adherence Achieves High HCV Cure Rates Among People Who Inject Drugs Treated With Direct-Acting Antiviral Agents
title_fullStr Low Adherence Achieves High HCV Cure Rates Among People Who Inject Drugs Treated With Direct-Acting Antiviral Agents
title_full_unstemmed Low Adherence Achieves High HCV Cure Rates Among People Who Inject Drugs Treated With Direct-Acting Antiviral Agents
title_short Low Adherence Achieves High HCV Cure Rates Among People Who Inject Drugs Treated With Direct-Acting Antiviral Agents
title_sort low adherence achieves high hcv cure rates among people who inject drugs treated with direct-acting antiviral agents
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7590860/
https://www.ncbi.nlm.nih.gov/pubmed/33134406
http://dx.doi.org/10.1093/ofid/ofaa377
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