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Case report of a neonate with high viral SARSCoV-2 loads and long-term virus shedding
BACKGROUND: SARS-CoV-2 has spread globally. Currently, literature of SARS-CoV-2 in neonates is scarce. We present a case of a neonate with a high viral load and prolonged virus shedding. METHODS: Epidemiology, clinical characteristics, treatment, laboratory data and follow-up information and the tre...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Authors. Published by Elsevier Ltd on behalf of King Saud Bin Abdulaziz University for Health Sciences.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7590917/ https://www.ncbi.nlm.nih.gov/pubmed/33158806 http://dx.doi.org/10.1016/j.jiph.2020.10.013 |
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author | Slaats, Monique A.L.J. Versteylen, Maud Gast, Karin B. Oude Munnink, Bas B. Pas, Suzan D. Bentvelsen, Robbert G. van Beek, Ron |
author_facet | Slaats, Monique A.L.J. Versteylen, Maud Gast, Karin B. Oude Munnink, Bas B. Pas, Suzan D. Bentvelsen, Robbert G. van Beek, Ron |
author_sort | Slaats, Monique A.L.J. |
collection | PubMed |
description | BACKGROUND: SARS-CoV-2 has spread globally. Currently, literature of SARS-CoV-2 in neonates is scarce. We present a case of a neonate with a high viral load and prolonged virus shedding. METHODS: Epidemiology, clinical characteristics, treatment, laboratory data and follow-up information and the treatment of a neonate with COVID-19 were recorded. RESULTS: A 7-day-old boy was admitted to the hospital with fever, lethargy and apnoea. He was found SARS-CoV-2 RNA positive with an exceptionally high viral load in nasopharyngeal swab and stool. The father and two maternity nurses at home had detectable SARS-CoV-2 RNA as well. Sequencing showed all strains belonged to the same cluster. The father was asymptomatic and the maternity nurses developed symptoms after visiting. In the mother, no SARS-CoV-2 RNA could be found. Six days after admission, the neonate was discharged after clinical improvement with oral antibiotics because of a possible pyelonephritis. Monitoring the course of this infection showed that SARS-CoV-2 RNA was detectable in the nasopharynx until day 19 and in stool until day 42 after symptom onset. CONCLUSIONS: This case shows that neonates can have a high viral load of SARS-CoV-2 and can shed the virus for over one month in stool. Despite the high viral load in the neonate, the mother and a sibling did not get infected. |
format | Online Article Text |
id | pubmed-7590917 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | The Authors. Published by Elsevier Ltd on behalf of King Saud Bin Abdulaziz University for Health Sciences. |
record_format | MEDLINE/PubMed |
spelling | pubmed-75909172020-10-28 Case report of a neonate with high viral SARSCoV-2 loads and long-term virus shedding Slaats, Monique A.L.J. Versteylen, Maud Gast, Karin B. Oude Munnink, Bas B. Pas, Suzan D. Bentvelsen, Robbert G. van Beek, Ron J Infect Public Health Case Report BACKGROUND: SARS-CoV-2 has spread globally. Currently, literature of SARS-CoV-2 in neonates is scarce. We present a case of a neonate with a high viral load and prolonged virus shedding. METHODS: Epidemiology, clinical characteristics, treatment, laboratory data and follow-up information and the treatment of a neonate with COVID-19 were recorded. RESULTS: A 7-day-old boy was admitted to the hospital with fever, lethargy and apnoea. He was found SARS-CoV-2 RNA positive with an exceptionally high viral load in nasopharyngeal swab and stool. The father and two maternity nurses at home had detectable SARS-CoV-2 RNA as well. Sequencing showed all strains belonged to the same cluster. The father was asymptomatic and the maternity nurses developed symptoms after visiting. In the mother, no SARS-CoV-2 RNA could be found. Six days after admission, the neonate was discharged after clinical improvement with oral antibiotics because of a possible pyelonephritis. Monitoring the course of this infection showed that SARS-CoV-2 RNA was detectable in the nasopharynx until day 19 and in stool until day 42 after symptom onset. CONCLUSIONS: This case shows that neonates can have a high viral load of SARS-CoV-2 and can shed the virus for over one month in stool. Despite the high viral load in the neonate, the mother and a sibling did not get infected. The Authors. Published by Elsevier Ltd on behalf of King Saud Bin Abdulaziz University for Health Sciences. 2020-12 2020-10-27 /pmc/articles/PMC7590917/ /pubmed/33158806 http://dx.doi.org/10.1016/j.jiph.2020.10.013 Text en © 2020 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Case Report Slaats, Monique A.L.J. Versteylen, Maud Gast, Karin B. Oude Munnink, Bas B. Pas, Suzan D. Bentvelsen, Robbert G. van Beek, Ron Case report of a neonate with high viral SARSCoV-2 loads and long-term virus shedding |
title | Case report of a neonate with high viral SARSCoV-2 loads and long-term virus shedding |
title_full | Case report of a neonate with high viral SARSCoV-2 loads and long-term virus shedding |
title_fullStr | Case report of a neonate with high viral SARSCoV-2 loads and long-term virus shedding |
title_full_unstemmed | Case report of a neonate with high viral SARSCoV-2 loads and long-term virus shedding |
title_short | Case report of a neonate with high viral SARSCoV-2 loads and long-term virus shedding |
title_sort | case report of a neonate with high viral sarscov-2 loads and long-term virus shedding |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7590917/ https://www.ncbi.nlm.nih.gov/pubmed/33158806 http://dx.doi.org/10.1016/j.jiph.2020.10.013 |
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