Cargando…

Synthesis, Cytotoxic Analysis, and Molecular Docking Studies of Tetrazole Derivatives via N-Mannich Base Condensation as Potential Antimicrobials

PURPOSE: A new series of tetrazole derivatives, which are renowned antimicrobials possessing a five-membered aromatic heterocyclic group, are synthesized herein and subjected to antimicrobial and cytotoxicity screening. METHODS: The tetrazole derivatives were synthesized via ultrasonication using Ma...

Descripción completa

Detalles Bibliográficos
Autores principales:	Atef Hatamleh, Ashraf, Al Farraj, Dunia, Salah Al-Saif, Sarah, Chidambaram, SathishKumar, Radhakrishnan, Surendrakumar, Akbar, Idhayadhulla
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2020
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7591006/ https://www.ncbi.nlm.nih.gov/pubmed/33122891 http://dx.doi.org/10.2147/DDDT.S270896

Ejemplares similares

In silico molecular docking: Evaluation of coumarin based derivatives against SARS-CoV-2
por: Chidambaram, Sathish Kumar, et al.
Publicado: (2020)

Larvicidal activity of novel anthraquinone analogues and their molecular docking studies
por: Selvaraj, Keerthana, et al.
Publicado: (2021)

Synthesis of novel coumarin analogues: Investigation of molecular docking interaction of SARS-CoV-2 proteins with natural and synthetic coumarin analogues and their pharmacokinetics studies
por: Chidambaram, Sathishkumar, et al.
Publicado: (2021)

Design of 1,4-Dihydropyridine Hybrid Benzamide Derivatives: Synthesis and Evaluation of Analgesic Activity and Their Molecular Docking Studies
por: Akbar, Idhayadhulla, et al.
Publicado: (2022)

Antioxidant Activity of Telmisartan–Cu(II) Nanoparticles Connected 2-Pyrimidinamine and Their Evaluation of Cytotoxicity Activities
por: Surendrakumar, Radhakrishnan, et al.
Publicado: (2020)

Tyrosinase-mediated synthesis of larvicidal active 1,5-diphenyl pent-4-en-1-one derivatives against Culex quinquefasciatus and investigation of their ichthyotoxicity
por: Chidambaram, SathishKumar, et al.
Publicado: (2021)

Synthesis of novel benzopyran-connected pyrimidine and pyrazole derivatives via a green method using Cu(ii)-tyrosinase enzyme catalyst as potential larvicidal, antifeedant activities
por: Abdel-Fattah Mostafa, Ashraf, et al.
Publicado: (2019)

New Chitosan Polymer Scaffold Schiff Bases as Potential Cytotoxic Activity: Synthesis, Molecular Docking, and Physiochemical Characterization
por: Packialakshmi, Ponnusamy, et al.
Publicado: (2022)

Mosquito larvicidal activity of pyrrolidine-2,4-dione derivatives: An investigation against Culex quinquefasciatus and molecular docking studies
por: Al-Zharani, Mohammed, et al.
Publicado: (2022)

Cu (II)-catalyzed: synthesis of imidazole derivatives and evaluating their larvicidal, antimicrobial activities with DFT and molecular docking studies
por: Mullaivendhan, Janani, et al.
Publicado: (2023)

Synthesis and Cytotoxic Activity of Novel Indole Derivatives and Their in silico Screening on Spike Glycoprotein of SARS-CoV-2
por: Gobinath, Perumal, et al.
Publicado: (2021)

Corrigendum: Synthesis and Cytotoxic Activity of Novel Indole Derivatives and Their in silico Screening on Spike Glycoprotein of SARS-CoV-2
por: Gobinath, Perumal, et al.
Publicado: (2021)

Synthesis and Characterization of a Minophosphonate Containing Chitosan Polymer Derivatives: Investigations of Cytotoxic Activity and in Silico Study of SARS-CoV-19
por: Packialakshmi, Ponnusamy, et al.
Publicado: (2021)

Grindstone Chemistry: Design, One-Pot Synthesis, and Promising Anticancer Activity of Spiro[acridine-9,2′-indoline]-1,3,8-trione Derivatives against the MCF-7 Cancer Cell Line
por: Gobinath, Perumal, et al.
Publicado: (2020)

Correction: Gobinath, P., et al. Grindstone Chemistry: Design, One-Pot Synthesis, and Promising Anticancer Activity of Spiro[acridine-9,2′-indoline]-1,3,8-trione Derivatives against the MCF-7 Cancer Cell Line. Molecules 2020, 25, 5862
por: Gobinath, Perumal, et al.
Publicado: (2021)

Nanobased Antibacterial Drug Discovery to Treat Skin Infections of Staphylococcus aureus Using Moringa oleifera-Assisted Zinc Oxide Nanoparticle and Molecular Simulation Study
por: Gobinath, Perumal, et al.
Publicado: (2022)

Host associated mixed probiotic bacteria induced digestive enzymes in the gut of tiger shrimp Penaeus monodon
por: Wang, Yin, et al.
Publicado: (2020)

Antimicrobial, anticoagulant, and cytotoxic evaluation of multidrug resistance of new 1,4-dihydropyridine derivatives
por: Ahamed, Anis, et al.
Publicado: (2018)

Cytotoxic, larvicidal, nematicidal, and antifeedant activities of piperidin-connected 2-thioxoimidazolidin-4-one derivatives
por: Arif, Ibrahim A., et al.
Publicado: (2019)

Synthesis, single crystal analysis, biological and docking evaluation of tetrazole derivatives
por: Aziz, Hamid, et al.
Publicado: (2018)

The Redox-Mannich Reaction
por: Chen, Weijie, et al.
Publicado: (2014)

Chiral Lewis acid-bonded picolinaldehyde enables enantiodivergent carbonyl catalysis in the Mannich/condensation reaction of glycine ester
por: Zhong, Xia, et al.
Publicado: (2021)

Cytotoxic Potential of Alternaria tenuissima AUMC14342 Mycoendophyte Extract: A Study Combined with LC-MS/MS Metabolic Profiling and Molecular Docking Simulation
por: Al Mousa, Amal A., et al.
Publicado: (2022)

Interactome Analysis and Docking Sites of MutS Homologs Reveal New Physiological Roles in Arabidopsis thaliana
por: AbdelGawwad, Mohamed Ragab, et al.
Publicado: (2019)

Study of 2-aminoquinolin-4(1H)-one under Mannich and retro-Mannich reaction
por: Funk, Petr, et al.
Publicado: (2017)

Investigations of Electronic, Structural, and In Silico Anticancer Potential of Persuasive Phytoestrogenic Isoflavene-Based Mannich Bases
por: Mutahir, Sadaf, et al.
Publicado: (2023)

Synthesis and characterization of N-Mannich based prodrugs of ciprofloxacin and norfloxacin: In vitro anthelmintic and cytotoxic evaluation
por: Piplani, Mona, et al.
Publicado: (2017)

Synthesis, Characterization, Antitubercular Activity, and Molecular Docking Studies of Pyrazolylpyrazoline-Clubbed Triazole and Tetrazole Hybrids
por: Zala, Mayursinh, et al.
Publicado: (2023)

The association between sociodemographic, hormonal, tubo-ovarian factors and bacterial count in Chlamydia and Mycoplasma infections with infertility
por: Al-Farraj, Dunia A., et al.
Publicado: (2019)

Virulence and cytotoxicity of seafood borne Aeromonas hydrophila
por: Illanchezian, Seethalakshmi, et al.
Publicado: (2010)

Synthesis of polybrominated benzimidazole and benzotriazole derivatives containing a tetrazole ring and their cytotoxic activity
por: Łukowska-Chojnacka, Edyta, et al.
Publicado: (2016)

A combined crystallographic and theoretical investigation of noncovalent interactions in 1,3,4-oxadiazole-2-thione-N-Mannich derivatives: in vitro bioactivity and molecular docking
por: Al-Wahaibi, Lamya H., et al.
Publicado: (2023)

New Approach for Using of Mentha longifolia L. and Citrus reticulata L. Essential Oils as Wood-Biofungicides: GC-MS, SEM, and MNDO Quantum Chemical Studies
por: Ali, Hayssam M., et al.
Publicado: (2021)

Dopamine-Mediated Vanillin Multicomponent Derivative Synthesis via Grindstone Method: Application of Antioxidant, Anti-Tyrosinase, and Cytotoxic Activities
por: Mani, Arunadevi, et al.
Publicado: (2021)

Studies on the Anthelmintic Property of Aminobenzylated Mannich Bases
por: Chaluvaraju, KC, et al.
Publicado: (2011)

Iridium-Catalyzed Reductive Nitro-Mannich Cyclization
por: Gregory, Alex W, et al.
Publicado: (2015)

Mannich Bases: An Important Pharmacophore in Present Scenario
por: Bala, Suman, et al.
Publicado: (2014)

Mannich bases in medicinal chemistry and drug design
por: Roman, Gheorghe
Publicado: (2015)

Three-component radical homo Mannich reaction
por: Shi, Shuai, et al.
Publicado: (2021)

Enantio- and diastereoselective conjugate borylation/Mannich cyclization
por: Larin, Egor M., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_ofsls9qi1650a6bcmb8tub6ou8