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A model-based evaluation of the efficacy of COVID-19 social distancing, testing and hospital triage policies

A stochastic compartmental network model of SARS-CoV-2 spread explores the simultaneous effects of policy choices in three domains: social distancing, hospital triaging, and testing. Considering policy domains together provides insight into how different policy decisions interact. The model incorpor...

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Detalles Bibliográficos
Autores principales: McCombs, Audrey, Kadelka, Claus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7591016/
https://www.ncbi.nlm.nih.gov/pubmed/33057438
http://dx.doi.org/10.1371/journal.pcbi.1008388
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author McCombs, Audrey
Kadelka, Claus
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Kadelka, Claus
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description A stochastic compartmental network model of SARS-CoV-2 spread explores the simultaneous effects of policy choices in three domains: social distancing, hospital triaging, and testing. Considering policy domains together provides insight into how different policy decisions interact. The model incorporates important characteristics of COVID-19, the disease caused by SARS-CoV-2, such as heterogeneous risk factors and asymptomatic transmission, and enables a reliable qualitative comparison of policy choices despite the current uncertainty in key virus and disease parameters. Results suggest possible refinements to current policies, including emphasizing the need to reduce random encounters more than personal contacts, and testing low-risk symptomatic individuals before high-risk symptomatic individuals. The strength of social distancing of symptomatic individuals affects the degree to which asymptomatic cases drive the epidemic as well as the level of population-wide contact reduction needed to keep hospitals below capacity. The relative importance of testing and triaging also depends on the overall level of social distancing.
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spelling pubmed-75910162020-10-30 A model-based evaluation of the efficacy of COVID-19 social distancing, testing and hospital triage policies McCombs, Audrey Kadelka, Claus PLoS Comput Biol Research Article A stochastic compartmental network model of SARS-CoV-2 spread explores the simultaneous effects of policy choices in three domains: social distancing, hospital triaging, and testing. Considering policy domains together provides insight into how different policy decisions interact. The model incorporates important characteristics of COVID-19, the disease caused by SARS-CoV-2, such as heterogeneous risk factors and asymptomatic transmission, and enables a reliable qualitative comparison of policy choices despite the current uncertainty in key virus and disease parameters. Results suggest possible refinements to current policies, including emphasizing the need to reduce random encounters more than personal contacts, and testing low-risk symptomatic individuals before high-risk symptomatic individuals. The strength of social distancing of symptomatic individuals affects the degree to which asymptomatic cases drive the epidemic as well as the level of population-wide contact reduction needed to keep hospitals below capacity. The relative importance of testing and triaging also depends on the overall level of social distancing. Public Library of Science 2020-10-15 /pmc/articles/PMC7591016/ /pubmed/33057438 http://dx.doi.org/10.1371/journal.pcbi.1008388 Text en © 2020 McCombs, Kadelka http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
McCombs, Audrey
Kadelka, Claus
A model-based evaluation of the efficacy of COVID-19 social distancing, testing and hospital triage policies
title A model-based evaluation of the efficacy of COVID-19 social distancing, testing and hospital triage policies
title_full A model-based evaluation of the efficacy of COVID-19 social distancing, testing and hospital triage policies
title_fullStr A model-based evaluation of the efficacy of COVID-19 social distancing, testing and hospital triage policies
title_full_unstemmed A model-based evaluation of the efficacy of COVID-19 social distancing, testing and hospital triage policies
title_short A model-based evaluation of the efficacy of COVID-19 social distancing, testing and hospital triage policies
title_sort model-based evaluation of the efficacy of covid-19 social distancing, testing and hospital triage policies
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7591016/
https://www.ncbi.nlm.nih.gov/pubmed/33057438
http://dx.doi.org/10.1371/journal.pcbi.1008388
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