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Association of Cigarette Smoking with Sleep Disturbance and Neurotransmitters in Cerebrospinal Fluid

BACKGROUND: Cigarette smoking has shown to be associated with sleep disturbance, especially prolonged sleep onset latency (SOL). Cigarette smoking stimulates the release of dopamine (DA) and serotonin (5-HT), which might promote awakening and inhibit rapid eye movement sleep. Dopamine transporter (D...

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Autores principales: Li, Hui, Liu, Yanlong, Xing, Lifei, Yang, Xiaoyu, Xu, Jinzhong, Ren, Qiushi, Su, Kuan-Pin, Lu, Yanye, Wang, Fan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7591043/
https://www.ncbi.nlm.nih.gov/pubmed/33122957
http://dx.doi.org/10.2147/NSS.S272883
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author Li, Hui
Liu, Yanlong
Xing, Lifei
Yang, Xiaoyu
Xu, Jinzhong
Ren, Qiushi
Su, Kuan-Pin
Lu, Yanye
Wang, Fan
author_facet Li, Hui
Liu, Yanlong
Xing, Lifei
Yang, Xiaoyu
Xu, Jinzhong
Ren, Qiushi
Su, Kuan-Pin
Lu, Yanye
Wang, Fan
author_sort Li, Hui
collection PubMed
description BACKGROUND: Cigarette smoking has shown to be associated with sleep disturbance, especially prolonged sleep onset latency (SOL). Cigarette smoking stimulates the release of dopamine (DA) and serotonin (5-HT), which might promote awakening and inhibit rapid eye movement sleep. Dopamine transporter (DAT) and serotonin transporter play a key role in the reuptake of DA and 5-HT from the synaptic cleft into presynaptic neurons. However, the relationship among cigarette smoking, sleep disturbance and neurotransmitters has never been investigated in human cerebrospinal fluid (CSF). METHODS: A total of 159 Chinese male subjects (81 active smokers and 78 non-smokers) who would undergo lumbar puncture before the surgery of anterior cruciate ligament reconstruction were recruited and 5mL-CSF samples were collected incidentally. CSF levels of DA, DAT, 5-HT, and serotonin transporter were measured using radioimmunoassay and ELISA. Sociodemographic data and the Pittsburgh Sleep Quality Index (PSQI) scale were collected before surgery. RESULTS: PSQI global scores, SOL, and CSF DA levels were significantly higher in active smokers compared to non-smokers (2.00 [1.00–4.75] scores vs 4.00 [3.00–6.00] scores, p = 0.001; 10.00 [5.00–15.00] minutes vs 15.00 [10.00–30.00] minutes, p = 0.002; 87.20 [82.31–96.06]ng/mL vs 107.45 [92.78–114.38] ng/mL, p < 0.001), while CSF DAT levels were significantly lower in active smokers (0.35 [0.31–0.39] ng/mL vs 0.29 [0.26–0.34] ng/mL, p < 0.001). CONCLUSION: Cigarette smoking was indeed associated with sleep disturbance, shown by prolonged SOL, higher DA levels and lower DAT levels in CSF of active smokers.
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spelling pubmed-75910432020-10-28 Association of Cigarette Smoking with Sleep Disturbance and Neurotransmitters in Cerebrospinal Fluid Li, Hui Liu, Yanlong Xing, Lifei Yang, Xiaoyu Xu, Jinzhong Ren, Qiushi Su, Kuan-Pin Lu, Yanye Wang, Fan Nat Sci Sleep Original Research BACKGROUND: Cigarette smoking has shown to be associated with sleep disturbance, especially prolonged sleep onset latency (SOL). Cigarette smoking stimulates the release of dopamine (DA) and serotonin (5-HT), which might promote awakening and inhibit rapid eye movement sleep. Dopamine transporter (DAT) and serotonin transporter play a key role in the reuptake of DA and 5-HT from the synaptic cleft into presynaptic neurons. However, the relationship among cigarette smoking, sleep disturbance and neurotransmitters has never been investigated in human cerebrospinal fluid (CSF). METHODS: A total of 159 Chinese male subjects (81 active smokers and 78 non-smokers) who would undergo lumbar puncture before the surgery of anterior cruciate ligament reconstruction were recruited and 5mL-CSF samples were collected incidentally. CSF levels of DA, DAT, 5-HT, and serotonin transporter were measured using radioimmunoassay and ELISA. Sociodemographic data and the Pittsburgh Sleep Quality Index (PSQI) scale were collected before surgery. RESULTS: PSQI global scores, SOL, and CSF DA levels were significantly higher in active smokers compared to non-smokers (2.00 [1.00–4.75] scores vs 4.00 [3.00–6.00] scores, p = 0.001; 10.00 [5.00–15.00] minutes vs 15.00 [10.00–30.00] minutes, p = 0.002; 87.20 [82.31–96.06]ng/mL vs 107.45 [92.78–114.38] ng/mL, p < 0.001), while CSF DAT levels were significantly lower in active smokers (0.35 [0.31–0.39] ng/mL vs 0.29 [0.26–0.34] ng/mL, p < 0.001). CONCLUSION: Cigarette smoking was indeed associated with sleep disturbance, shown by prolonged SOL, higher DA levels and lower DAT levels in CSF of active smokers. Dove 2020-10-23 /pmc/articles/PMC7591043/ /pubmed/33122957 http://dx.doi.org/10.2147/NSS.S272883 Text en © 2020 Li et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Li, Hui
Liu, Yanlong
Xing, Lifei
Yang, Xiaoyu
Xu, Jinzhong
Ren, Qiushi
Su, Kuan-Pin
Lu, Yanye
Wang, Fan
Association of Cigarette Smoking with Sleep Disturbance and Neurotransmitters in Cerebrospinal Fluid
title Association of Cigarette Smoking with Sleep Disturbance and Neurotransmitters in Cerebrospinal Fluid
title_full Association of Cigarette Smoking with Sleep Disturbance and Neurotransmitters in Cerebrospinal Fluid
title_fullStr Association of Cigarette Smoking with Sleep Disturbance and Neurotransmitters in Cerebrospinal Fluid
title_full_unstemmed Association of Cigarette Smoking with Sleep Disturbance and Neurotransmitters in Cerebrospinal Fluid
title_short Association of Cigarette Smoking with Sleep Disturbance and Neurotransmitters in Cerebrospinal Fluid
title_sort association of cigarette smoking with sleep disturbance and neurotransmitters in cerebrospinal fluid
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7591043/
https://www.ncbi.nlm.nih.gov/pubmed/33122957
http://dx.doi.org/10.2147/NSS.S272883
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