Cargando…

Quantification of Thioguanine in DNA Using Liquid Chromatography-Tandem Mass Spectrometry for Routine Thiopurine Drug Monitoring in Patients With Pediatric Acute Lymphoblastic Leukemia

BACKGROUND: We developed an assay to measure DNA-incorporated 6-thioguanine (DNA-TG) and validated its clinical applicability in Korean pediatric patients with acute lymphoblastic leukemia (ALL) in order to improve individualized thiopurine treatment and reduce the life-threatening cytotoxicity. MET...

Descripción completa

Detalles Bibliográficos
Autores principales:	Choi, Rihwa, Chun, Mi Ryung, Park, Jisook, Lee, Ji Won, Ju, Hee Young, Cho, Hee Won, Hyun, Ju Kyung, Koo, Hong Hoe, Yi, Eun Sang, Lee, Soo-Youn
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Korean Society for Laboratory Medicine 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7591283/ https://www.ncbi.nlm.nih.gov/pubmed/33063676 http://dx.doi.org/10.3343/alm.2021.41.2.145

Ejemplares similares

DNA-thioguanine nucleotide as a treatment marker in acute lymphoblastic leukemia patients with NUDT15 variant genotypes
por: Ju, Hee Young, et al.
Publicado: (2021)

Increments in DNA-thioguanine level during thiopurine-enhanced maintenance therapy of acute lymphoblastic leukemia
por: Larsen, Rikke Hebo, et al.
Publicado: (2021)

Quantification of Thiopurine Nucleotides in Erythrocytes and Clinical Application to Pediatric Acute Lymphoblastic Leukemia
por: Moon, Soo Young, et al.
Publicado: (2019)

Identification and Quantification of Glucosinolates in Kimchi by Liquid Chromatography-Electrospray Tandem Mass Spectrometry
por: Kim, Ho Jin, et al.
Publicado: (2017)

Dried Blood Spot Multiplexed Steroid Profiling Using Liquid Chromatography Tandem Mass Spectrometry in Korean Neonates
por: Choi, Rihwa, et al.
Publicado: (2019)

Relationship Between Thiopurine S-Methyltransferase Genotype/Phenotype and 6-Thioguanine Nucleotide Levels in 316 Patients With Inflammatory Bowel Disease on 6-Thioguanine
por: Bayoumy, Ahmed B., et al.
Publicado: (2021)

Quantification of Human Plasma-Busulfan Concentration by Liquid Chromatography-Tandem Mass Spectrometry
por: Moon, Soo Young, et al.
Publicado: (2014)

Thiopurine Methyltransferase Predicts the Extent of Cytotoxicty and DNA Damage in Astroglial Cells after Thioguanine Exposure
por: Hosni-Ahmed, Amira, et al.
Publicado: (2011)

Quantification of apixaban in human plasma using ultra performance liquid chromatography coupled with tandem mass spectrometry
por: Jeong, Hyeon-Cheol, et al.
Publicado: (2019)

Identification and Quantification of Dimethylamylamine in Geranium by Liquid Chromatography Tandem Mass Spectrometry
por: Li, J.S., et al.
Publicado: (2012)

Development and Validation of Liquid Chromatography-Tandem Mass Spectrometry Method for Quantification of Plasma Metanephrines for Differential Diagnosis of Adrenal Incidentaloma
por: Lee, Sae-Mi, et al.
Publicado: (2015)

Clinical Usefulness of Ultraperformance Liquid Chromatography-Tandem Mass Spectrometry Method for Low Serum Testosterone Measurement
por: Cho, Sung-Eun, et al.
Publicado: (2023)

Liquid Chromatography Tandem Mass Spectrometry Quantification of (13)C-Labeling in Sugars
por: Cocuron, Jean-Christophe, et al.
Publicado: (2020)

Quantification of nitromethane in mainstream smoke using gas chromatography and tandem mass spectrometry
por: Junco, Juliana Giraldo, et al.
Publicado: (2021)

Excited-State Dynamics of the Thiopurine Prodrug 6-Thioguanine: Can N9-Glycosylation Affect Its Phototoxic Activity?
por: Ashwood, Brennan, et al.
Publicado: (2017)

Normal Ranges of Thiopurine Methyltransferase Activity Do Not Affect Thioguanine Nucleotide Concentrations With Azathioprine Therapy in Inflammatory Bowel Disease
por: Jonason, David E, et al.
Publicado: (2020)

Liquid chromatography–mass spectrometry for measuring deoxythioguanosine in DNA from thiopurine-treated patients
por: Coulthard, Sally A., et al.
Publicado: (2016)

NUDT15 Variants Cause Hematopoietic Toxicity with Low 6-TGN Levels in Children with Acute Lymphoblastic Leukemia
por: Yi, Eun Sang, et al.
Publicado: (2018)

Simultaneous determination of cardiovascular drugs in dried blood spot by liquid chromatography-tandem mass spectrometry
por: Kim, Hyung Min, et al.
Publicado: (2019)

Quantification of artemisinin in human plasma using liquid chromatography coupled to tandem mass spectrometry
por: Lindegardh, N., et al.
Publicado: (2009)

Simultaneous Quantification of Multiple Urinary Naphthalene Metabolites by Liquid Chromatography Tandem Mass Spectrometry
por: Ayala, Daniel C., et al.
Publicado: (2015)

Simultaneous quantification of amiloride and hydrochlorothiazide in human plasma by liquid chromatography–tandem mass spectrometry
por: Shah, Jaivik V., et al.
Publicado: (2017)

Quantification of total dinutuximab concentrations in neuroblastoma patients with liquid chromatography tandem mass spectrometry
por: El Amrani, Mohsin, et al.
Publicado: (2018)

Simultaneous Quantification of Trace and Micro Phenolic Compounds by Liquid Chromatography Tandem-Mass Spectrometry
por: Wang, Dandan, et al.
Publicado: (2021)

Simple and fast quantification of cannabinoids in animal feeds by liquid chromatography–tandem mass spectrometry
por: Xu, Xin, et al.
Publicado: (2023)

Concomitant 5-aminosalicylic acid treatment does not affect 6-thioguanine nucleotide levels in patients with inflammatory bowel disease on thiopurines
por: Looser, Rahel, et al.
Publicado: (2023)

Simultaneous Quantification of 22 Glucosinolates in 12 Brassicaceae Vegetables by Hydrophilic Interaction Chromatography–Tandem Mass Spectrometry
por: Liang, Xu, et al.
Publicado: (2018)

Simultaneous Quantification of Chloramphenicol, Thiamphenicol, Florfenicol, and Florfenicol Amine in Animal and Aquaculture Products Using Liquid Chromatography-Tandem Mass Spectrometry
por: Jung, Hae-Ni, et al.
Publicado: (2022)

Quantification of thioguanine-resistant lymphocytes from mice irradiated in vivo.
por: Lorenz, R, et al.
Publicado: (1990)

Assessment of Thiopurine–based drugs according to Thiopurine S-methyltransferase genotype in patients with Acute Lymphoblastic Leukemia
por: Azimi, F, et al.
Publicado: (2014)

Thiopurine dose intensity and treatment outcome in childhood lymphoblastic leukaemia: the influence of thiopurine methyltransferase pharmacogenetics
por: Lennard, Lynne, et al.
Publicado: (2014)

Quantification of Morpholine in Peel and Pulp of Apples and Oranges by Gas Chromatography−Mass Spectrometry
por: An, Kunho, et al.
Publicado: (2020)

Uncertainty Evaluation for the Quantification of Urinary Amphetamine and 4-Hydroxyamphetamine Using Liquid Chromatography–Tandem Mass Spectrometry: Comparison of the Guide to the Expression of Uncertainty in Measurement Approach and the Monte Carlo Method with R
por: Kim, Seon Yeong, et al.
Publicado: (2023)

Determination of Heterocyclic Amines and Acrylamide in Agricultural Products with Liquid Chromatography-Tandem Mass Spectrometry
por: Lee, Kyung-Jun, et al.
Publicado: (2015)

Quantification of isocyanates and amines in polyurethane foams and coated products by liquid chromatography–tandem mass spectrometry
por: Mutsuga, Motoh, et al.
Publicado: (2014)

A Review on Liquid Chromatography-Tandem Mass Spectrometry Methods for Rapid Quantification of Oncology Drugs
por: Wong, Andrea Li-Ann, et al.
Publicado: (2018)

High-Throughput Liquid Chromatography–Tandem Mass Spectrometry Quantification of Glycosaminoglycans as Biomarkers of Mucopolysaccharidosis II
por: Wang, Junhua, et al.
Publicado: (2020)

Simultaneous quantification of estrogens and glucocorticoids in human adipose tissue by liquid-chromatography-tandem mass spectrometry
por: Laforest, Sofia, et al.
Publicado: (2019)

Quantification of Colistin in Plasma by Liquid Chromatography-Tandem Mass Spectrometry: Application to a Pharmacokinetic Study
por: Matar, Kamal M., et al.
Publicado: (2020)

Liquid chromatography-tandem mass spectrometry analysis for identification and quantification of antimicrobial compounds in distillery wastewater
por: Hou, Waner, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_96beusou1tcfsgajo1tp5v0de7