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Characterization of AAV-Specific Affinity Ligands: Consequences for Vector Purification and Development Strategies

Affinity-based purification of adeno-associated virus (AAV) vectors has replaced density-based methods for vectors used in clinical settings. This method utilizes camelid single-domain antibodies recognizing AAV capsids. These include AVB Sepharose (AVB) and POROS CaptureSelect affinity ligand for A...

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Detalles Bibliográficos
Autores principales:	Mietzsch, Mario, Smith, J. Kennon, Yu, Jennifer C., Banala, Vibhu, Emmanuel, Shanan N., Jose, Ariana, Chipman, Paul, Bhattacharya, Nilakshee, McKenna, Robert, Agbandje-McKenna, Mavis
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2020
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7591348/ https://www.ncbi.nlm.nih.gov/pubmed/33145372 http://dx.doi.org/10.1016/j.omtm.2020.10.001

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