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Wnt signaling in kidney: the initiator or terminator?

The kidney is a key organ in the human body that excretes toxins and sustains the water–electrolyte balance. During embryonic development and disease progression, the kidney undergoes enormous changes in macrostructure, accompanied by a variety of microstructural histological changes, such as glomer...

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Autores principales: Meng, Ping, Zhu, Mingsheng, Ling, Xian, Zhou, Lili
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7591426/
https://www.ncbi.nlm.nih.gov/pubmed/32939578
http://dx.doi.org/10.1007/s00109-020-01978-9
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author Meng, Ping
Zhu, Mingsheng
Ling, Xian
Zhou, Lili
author_facet Meng, Ping
Zhu, Mingsheng
Ling, Xian
Zhou, Lili
author_sort Meng, Ping
collection PubMed
description The kidney is a key organ in the human body that excretes toxins and sustains the water–electrolyte balance. During embryonic development and disease progression, the kidney undergoes enormous changes in macrostructure, accompanied by a variety of microstructural histological changes, such as glomerular formation and sclerosis, tubule elongation and atrophy, interstitial establishment, and fibrosis progression. All of these rely on the frequent occurrence of cell death and growth. Notably, to overcome disease, some cells regenerate through self-repair or progenitor cell differentiation. However, the signaling mechanisms underlying kidney development and regeneration have not been elucidated. Recently, Wnt signaling has been noted to play an important role. Although it is a well-known developmental signal, the role of Wnt signaling in kidney development and regeneration is not well recognized. In this review, we review the role of Wnt signaling in kidney embryonic development, tissue repair, cell division, and progenitor cell differentiation after injury. Moreover, we briefly highlight advances in our understanding of the pathogenic mechanisms of Wnt signaling in mediating cellular senescence in kidney parenchymal and stem cells, an irreversible arrest of cell proliferation blocking tissue repair and regeneration. We also highlight the therapeutic targets of Wnt signaling in kidney diseases and provide important clues for clinical strategies.
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spelling pubmed-75914262020-10-29 Wnt signaling in kidney: the initiator or terminator? Meng, Ping Zhu, Mingsheng Ling, Xian Zhou, Lili J Mol Med (Berl) Review The kidney is a key organ in the human body that excretes toxins and sustains the water–electrolyte balance. During embryonic development and disease progression, the kidney undergoes enormous changes in macrostructure, accompanied by a variety of microstructural histological changes, such as glomerular formation and sclerosis, tubule elongation and atrophy, interstitial establishment, and fibrosis progression. All of these rely on the frequent occurrence of cell death and growth. Notably, to overcome disease, some cells regenerate through self-repair or progenitor cell differentiation. However, the signaling mechanisms underlying kidney development and regeneration have not been elucidated. Recently, Wnt signaling has been noted to play an important role. Although it is a well-known developmental signal, the role of Wnt signaling in kidney development and regeneration is not well recognized. In this review, we review the role of Wnt signaling in kidney embryonic development, tissue repair, cell division, and progenitor cell differentiation after injury. Moreover, we briefly highlight advances in our understanding of the pathogenic mechanisms of Wnt signaling in mediating cellular senescence in kidney parenchymal and stem cells, an irreversible arrest of cell proliferation blocking tissue repair and regeneration. We also highlight the therapeutic targets of Wnt signaling in kidney diseases and provide important clues for clinical strategies. Springer Berlin Heidelberg 2020-09-17 2020 /pmc/articles/PMC7591426/ /pubmed/32939578 http://dx.doi.org/10.1007/s00109-020-01978-9 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review
Meng, Ping
Zhu, Mingsheng
Ling, Xian
Zhou, Lili
Wnt signaling in kidney: the initiator or terminator?
title Wnt signaling in kidney: the initiator or terminator?
title_full Wnt signaling in kidney: the initiator or terminator?
title_fullStr Wnt signaling in kidney: the initiator or terminator?
title_full_unstemmed Wnt signaling in kidney: the initiator or terminator?
title_short Wnt signaling in kidney: the initiator or terminator?
title_sort wnt signaling in kidney: the initiator or terminator?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7591426/
https://www.ncbi.nlm.nih.gov/pubmed/32939578
http://dx.doi.org/10.1007/s00109-020-01978-9
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