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Maternal DNMT3A-dependent de novo methylation of the paternal genome inhibits gene expression in the early embryo

De novo DNA methylation (DNAme) during mammalian spermatogenesis yields a densely methylated genome, with the exception of CpG islands (CGIs), which are hypomethylated in sperm. While the paternal genome undergoes widespread DNAme loss before the first S-phase following fertilization, recent mass sp...

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Detalles Bibliográficos
Autores principales:	Richard Albert, Julien, Au Yeung, Wan Kin, Toriyama, Keisuke, Kobayashi, Hisato, Hirasawa, Ryutaro, Brind’Amour, Julie, Bogutz, Aaron, Sasaki, Hiroyuki, Lorincz, Matthew
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7591512/ https://www.ncbi.nlm.nih.gov/pubmed/33110091 http://dx.doi.org/10.1038/s41467-020-19279-7

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