Interleukin 35 Delays Hindlimb Ischemia-Induced Angiogenesis Through Regulating ROS-Extracellular Matrix but Spares Later Regenerative Angiogenesis

Interleukin (IL) 35 is a novel immunosuppressive heterodimeric cytokine in IL-12 family. Whether and how IL-35 regulates ischemia-induced angiogenesis in peripheral artery diseases are unrevealed. To fill this important knowledge gap, we used loss-of-function, gain-of-function, omics data analysis,...

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Detalles Bibliográficos
Autores principales: Fu, Hangfei, Sun, Yu, Shao, Ying, Saredy, Jason, Cueto, Ramon, Liu, Lu, Drummer, Charles, Johnson, Candice, Xu, Keman, Lu, Yifan, Li, Xinyuan, Meng, Shu, Xue, Eric R., Tan, Judy, Jhala, Nirag C., Yu, Daohai, Zhou, Yan, Bayless, Kayla J., Yu, Jun, Rogers, Thomas J., Hu, Wenhui, Snyder, Nathaniel W., Sun, Jianxin, Qin, Xuebin, Jiang, Xiaohua, Wang, Hong, Yang, Xiaofeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7591706/
https://www.ncbi.nlm.nih.gov/pubmed/33154757
http://dx.doi.org/10.3389/fimmu.2020.595813

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