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Disease burden and clinical severity of the first pandemic wave of COVID-19 in Wuhan, China
The novel coronavirus disease 2019 (COVID-19) was first reported in Wuhan, China, where the initial wave of intense community transmissions was cut short by interventions. Using multiple data sources, here we estimate the disease burden and clinical severity by age of COVID-19 in Wuhan from December...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7591855/ https://www.ncbi.nlm.nih.gov/pubmed/33110070 http://dx.doi.org/10.1038/s41467-020-19238-2 |
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author | Yang, Juan Chen, Xinhua Deng, Xiaowei Chen, Zhiyuan Gong, Hui Yan, Han Wu, Qianhui Shi, Huilin Lai, Shengjie Ajelli, Marco Viboud, Cecile Yu, Prof Hongjie |
author_facet | Yang, Juan Chen, Xinhua Deng, Xiaowei Chen, Zhiyuan Gong, Hui Yan, Han Wu, Qianhui Shi, Huilin Lai, Shengjie Ajelli, Marco Viboud, Cecile Yu, Prof Hongjie |
author_sort | Yang, Juan |
collection | PubMed |
description | The novel coronavirus disease 2019 (COVID-19) was first reported in Wuhan, China, where the initial wave of intense community transmissions was cut short by interventions. Using multiple data sources, here we estimate the disease burden and clinical severity by age of COVID-19 in Wuhan from December 1, 2019 to March 31, 2020. Our estimates account for the sensitivity of the laboratory assays, prospective community screenings, and healthcare seeking behaviors. Rates of symptomatic cases, medical consultations, hospitalizations and deaths were estimated at 796 (95% CI: 703–977), 489 (472–509), 370 (358–384), and 36.2 (35.0–37.3) per 100,000 persons, respectively. The COVID-19 outbreak in Wuhan had a higher burden than the 2009 influenza pandemic or seasonal influenza in terms of hospitalization and mortality rates, and clinical severity was similar to that of the 1918 influenza pandemic. Our comparison puts the COVID-19 pandemic into context and could be helpful to guide intervention strategies and preparedness for the potential resurgence of COVID-19. |
format | Online Article Text |
id | pubmed-7591855 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-75918552020-11-10 Disease burden and clinical severity of the first pandemic wave of COVID-19 in Wuhan, China Yang, Juan Chen, Xinhua Deng, Xiaowei Chen, Zhiyuan Gong, Hui Yan, Han Wu, Qianhui Shi, Huilin Lai, Shengjie Ajelli, Marco Viboud, Cecile Yu, Prof Hongjie Nat Commun Article The novel coronavirus disease 2019 (COVID-19) was first reported in Wuhan, China, where the initial wave of intense community transmissions was cut short by interventions. Using multiple data sources, here we estimate the disease burden and clinical severity by age of COVID-19 in Wuhan from December 1, 2019 to March 31, 2020. Our estimates account for the sensitivity of the laboratory assays, prospective community screenings, and healthcare seeking behaviors. Rates of symptomatic cases, medical consultations, hospitalizations and deaths were estimated at 796 (95% CI: 703–977), 489 (472–509), 370 (358–384), and 36.2 (35.0–37.3) per 100,000 persons, respectively. The COVID-19 outbreak in Wuhan had a higher burden than the 2009 influenza pandemic or seasonal influenza in terms of hospitalization and mortality rates, and clinical severity was similar to that of the 1918 influenza pandemic. Our comparison puts the COVID-19 pandemic into context and could be helpful to guide intervention strategies and preparedness for the potential resurgence of COVID-19. Nature Publishing Group UK 2020-10-27 /pmc/articles/PMC7591855/ /pubmed/33110070 http://dx.doi.org/10.1038/s41467-020-19238-2 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Yang, Juan Chen, Xinhua Deng, Xiaowei Chen, Zhiyuan Gong, Hui Yan, Han Wu, Qianhui Shi, Huilin Lai, Shengjie Ajelli, Marco Viboud, Cecile Yu, Prof Hongjie Disease burden and clinical severity of the first pandemic wave of COVID-19 in Wuhan, China |
title | Disease burden and clinical severity of the first pandemic wave of COVID-19 in Wuhan, China |
title_full | Disease burden and clinical severity of the first pandemic wave of COVID-19 in Wuhan, China |
title_fullStr | Disease burden and clinical severity of the first pandemic wave of COVID-19 in Wuhan, China |
title_full_unstemmed | Disease burden and clinical severity of the first pandemic wave of COVID-19 in Wuhan, China |
title_short | Disease burden and clinical severity of the first pandemic wave of COVID-19 in Wuhan, China |
title_sort | disease burden and clinical severity of the first pandemic wave of covid-19 in wuhan, china |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7591855/ https://www.ncbi.nlm.nih.gov/pubmed/33110070 http://dx.doi.org/10.1038/s41467-020-19238-2 |
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