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Structure of human steroid 5α-reductase 2 with the anti-androgen drug finasteride

Human steroid 5α-reductase 2 (SRD5A2) is an integral membrane enzyme in steroid metabolism and catalyzes the reduction of testosterone to dihydrotestosterone. Mutations in the SRD5A2 gene have been linked to 5α-reductase deficiency and prostate cancer. Finasteride and dutasteride, as SRD5A2 inhibito...

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Detalles Bibliográficos
Autores principales:	Xiao, Qingpin, Wang, Lei, Supekar, Shreyas, Shen, Tao, Liu, Heng, Ye, Fei, Huang, Junzhou, Fan, Hao, Wei, Zhiyi, Zhang, Cheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7591894/ https://www.ncbi.nlm.nih.gov/pubmed/33110062 http://dx.doi.org/10.1038/s41467-020-19249-z

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