Cargando…

Complete loss of ATM function augments replication catastrophe induced by ATR inhibition and gemcitabine in pancreatic cancer models

BACKGROUND: Personalised medicine strategies may improve outcomes in pancreatic ductal adenocarcinoma (PDAC), but validation of predictive biomarkers is required. Having developed a clinical trial to assess the ATR inhibitor, AZD6738, in combination with gemcitabine (ATRi/gem), we investigated ATM l...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dunlop, Charles R., Wallez, Yann, Johnson, Timothy Isaac, Bernaldo de Quirós Fernández, Sandra, Durant, Stephen T., Cadogan, Elaine B., Lau, Alan, Richards, Frances M., Jodrell, Duncan I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7591912/ https://www.ncbi.nlm.nih.gov/pubmed/32741974 http://dx.doi.org/10.1038/s41416-020-1016-2

Ejemplares similares

Quantifying cell cycle-dependent drug sensitivities in cancer using a high throughput synchronisation and screening approach
por: Johnson, Timothy I., et al.
Publicado: (2021)

Functional analyses of ATM, ATR and Fanconi anemia proteins in lung carcinoma: ATM, ATR and FA in lung carcinoma
por: Beumer, Jan H., et al.
Publicado: (2015)

Versatility of the Mec1(ATM/ATR) signaling network in mediating resistance to replication, genotoxic, and proteotoxic stresses
por: Corcoles-Saez, Isaac, et al.
Publicado: (2019)

ATM and ATR Activities Maintain Replication Fork Integrity during SV40 Chromatin Replication
por: Sowd, Gregory A., et al.
Publicado: (2013)

"ATR activation in response to ionizing radiation: still ATM territory"
por: Cuadrado, Myriam, et al.
Publicado: (2006)

pRAD50: a novel and clinically applicable pharmacodynamic biomarker of both ATM and ATR inhibition identified using mass spectrometry and immunohistochemistry
por: Jones, Gemma N., et al.
Publicado: (2018)

A Replication stress biomarker is associated with response to gemcitabine versus combined gemcitabine and ATR inhibitor therapy in ovarian cancer
por: Konstantinopoulos, Panagiotis A., et al.
Publicado: (2021)

Pharmacologic ATM but not ATR kinase inhibition abrogates p21-dependent G1 arrest and promotes gastrointestinal syndrome after total body irradiation
por: Vendetti, Frank P., et al.
Publicado: (2017)

Cancer genome datamining and functional genetic analysis implicate mechanisms of ATM/ATR dysfunction underpinning carcinogenesis
por: Waskiewicz, Erik, et al.
Publicado: (2021)

Stabilization of quadruplex DNA perturbs telomere replication leading to the activation of an ATR-dependent ATM signaling pathway
por: Rizzo, Angela, et al.
Publicado: (2009)

Distinct roles for DNA-PK, ATM and ATR in RPA phosphorylation and checkpoint activation in response to replication stress
por: Liu, Shengqin, et al.
Publicado: (2012)

ATM and ATR Expression Potentiates HBV Replication and Contributes to Reactivation of HBV Infection upon DNA Damage
por: Kostyusheva, Anastasiya, et al.
Publicado: (2019)

Replisome dysfunction upon inducible TIMELESS degradation synergizes with ATR inhibition to trigger replication catastrophe
por: Patel, Jinal A, et al.
Publicado: (2023)

ATR Inhibitor AZD6738 (Ceralasertib) Exerts Antitumor Activity as a Monotherapy and in Combination with Chemotherapy and the PARP Inhibitor Olaparib
por: Wilson, Zena, et al.
Publicado: (2022)

ATR Contributes More Than ATM in Intra-S-Phase Checkpoint Activation after IR, and DNA-PKcs Facilitates Recovery: Evidence for Modular Integration of ATM/ATR/DNA-PKcs Functions
por: Soni, Aashish, et al.
Publicado: (2022)

DNA Damage Activates the SAC in an ATM/ATR-Dependent Manner, Independently of the Kinetochore
por: Kim, Eun Mi, et al.
Publicado: (2008)

ATM regulates ATR chromatin loading in response to DNA double-strand breaks
por: Cuadrado, Myriam, et al.
Publicado: (2006)

Disparate roles of ATR and ATM in immunoglobulin class switch recombination and somatic hypermutation
por: Pan-Hammarström, Qiang, et al.
Publicado: (2006)

Analysis of the ATR-Chk1 and ATM-Chk2 pathways in male breast cancer revealed the prognostic significance of ATR expression
por: Di Benedetto, Anna, et al.
Publicado: (2017)

Depletion of Macrophages Improves Therapeutic Response to Gemcitabine in Murine Pancreas Cancer
por: Buchholz, Soeren M., et al.
Publicado: (2020)

Shift in G(1)-Checkpoint from ATM-Alone to a Cooperative ATM Plus ATR Regulation with Increasing Dose of Radiation
por: Li, Fanghua, et al.
Publicado: (2021)

Combined PARP and ATR inhibition potentiates genome instability and cell death in ATM-deficient cancer cells
por: Lloyd, Rebecca L., et al.
Publicado: (2020)

SPOP mutation induces replication over-firing by impairing Geminin ubiquitination and triggers replication catastrophe upon ATR inhibition
por: Ma, Jian, et al.
Publicado: (2021)

Drosophila ATM and ATR have distinct activities in the regulation of meiotic DNA damage and repair
por: Joyce, Eric F., et al.
Publicado: (2011)

Distinct roles of ATM and ATR in the regulation of ARP8 phosphorylation to prevent chromosome translocations
por: Sun, Jiying, et al.
Publicado: (2018)

The Importance of ATM and ATR in Physcomitrella patens DNA Damage Repair, Development, and Gene Targeting
por: Martens, Martin, et al.
Publicado: (2020)

ATM, ATR and DNA-PKcs kinases—the lessons from the mouse models: inhibition ≠ deletion
por: Menolfi, Demis, et al.
Publicado: (2020)

Phosphorylation of seryl-tRNA synthetase by ATM/ATR is essential for hypoxia-induced angiogenesis
por: Shi, Yi, et al.
Publicado: (2020)

ATR inhibition overcomes platinum tolerance associated with ERCC1- and p53-deficiency by inducing replication catastrophe
por: Heyza, Joshua R, et al.
Publicado: (2023)

Cytosolic 5′-nucleotidase 1A is overexpressed in pancreatic cancer and mediates gemcitabine resistance by reducing intracellular gemcitabine metabolites
por: Patzak, Melanie S., et al.
Publicado: (2019)

Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling
por: Quin, Jaclyn, et al.
Publicado: (2016)

A novel method for quantification of gemcitabine and its metabolites 2′,2′-difluorodeoxyuridine and gemcitabine triphosphate in tumour tissue by LC–MS/MS: comparison with (19)F NMR spectroscopy
por: Bapiro, Tashinga E., et al.
Publicado: (2011)

Roles of ATM and ATR-Mediated DNA Damage Responses during Lytic BK Polyomavirus Infection
por: Jiang, Mengxi, et al.
Publicado: (2012)

CUX1 transcription factor is required for optimal ATM/ATR-mediated responses to DNA damage
por: Vadnais, Charles, et al.
Publicado: (2012)

The ATM- and ATR-related SCD domain is over-represented in proteins involved in nervous system development
por: Cara, Lukas, et al.
Publicado: (2016)

ATM, ATR and DNA-PKcs expressions correlate to adverse clinical outcomes in epithelial ovarian cancers
por: Abdel-Fatah, Tarek M.A., et al.
Publicado: (2014)

Selective human inhibitors of ATR and ATM render Leishmania major promastigotes sensitive to oxidative damage
por: da Silva, Raíssa Bernardes, et al.
Publicado: (2018)

Trial Watch: Targeting ATM–CHK2 and ATR–CHK1 pathways for anticancer therapy
por: Manic, Gwenola, et al.
Publicado: (2015)

β-HPV 8E6 Attenuates ATM and ATR Signaling in Response to UV Damage
por: Snow, Jazmine A., et al.
Publicado: (2019)

Aldehyde dehydrogenase inhibitors promote DNA damage in ovarian cancer and synergize with ATM/ATR inhibitors
por: Grimley, Edward, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_g79pfmk83u7jiqrd1jh25sibva