High expression of CD34 and α6-integrin contributes to the cancer-initiating cell behaviour in ultraviolet-induced mouse skin squamous cell carcinoma

Squamous cell carcinoma caused by ultraviolet light exposure represents over 40% of all malignant diseases. It is one of the most commonly found human tumours. Tumour mass within squamous cell carcinoma consists of various cell types, including cancer-initiating cells that are responsible for tumour...

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Autores principales: Ke, Hengning, Yang, YvYing, Lin, Yuan, Liu, Li, Sun, Jianmin, Massoumi, Ramin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7592010/
https://www.ncbi.nlm.nih.gov/pubmed/33123267
http://dx.doi.org/10.7150/jca.45819
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author Ke, Hengning
Yang, YvYing
Lin, Yuan
Liu, Li
Sun, Jianmin
Massoumi, Ramin
author_facet Ke, Hengning
Yang, YvYing
Lin, Yuan
Liu, Li
Sun, Jianmin
Massoumi, Ramin
author_sort Ke, Hengning
collection PubMed
description Squamous cell carcinoma caused by ultraviolet light exposure represents over 40% of all malignant diseases. It is one of the most commonly found human tumours. Tumour mass within squamous cell carcinoma consists of various cell types, including cancer-initiating cells that are responsible for tumour progression, metastasis and chemoresistance and implicated in clinical relapse. In the present study, we aimed to characterise whether the cell population with high CD34 and α6-integrin expression behave as cancer-initiating cells within ultraviolet-induced squamous cell carcinoma in mouse skin. CD34(high)α6-integrin(high) compared to CD34(low)α6-integrin(high) cells isolated from ultraviolet-induced squamous cell carcinoma could propagate effectively by displaying greater tumour initiating and self-renewal abilities. Our study suggests that CD34(high)α6-integrin(high) cells act as initiators upon ultraviolet-induced skin squamous cell carcinoma.
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spelling pubmed-75920102020-10-28 High expression of CD34 and α6-integrin contributes to the cancer-initiating cell behaviour in ultraviolet-induced mouse skin squamous cell carcinoma Ke, Hengning Yang, YvYing Lin, Yuan Liu, Li Sun, Jianmin Massoumi, Ramin J Cancer Research Paper Squamous cell carcinoma caused by ultraviolet light exposure represents over 40% of all malignant diseases. It is one of the most commonly found human tumours. Tumour mass within squamous cell carcinoma consists of various cell types, including cancer-initiating cells that are responsible for tumour progression, metastasis and chemoresistance and implicated in clinical relapse. In the present study, we aimed to characterise whether the cell population with high CD34 and α6-integrin expression behave as cancer-initiating cells within ultraviolet-induced squamous cell carcinoma in mouse skin. CD34(high)α6-integrin(high) compared to CD34(low)α6-integrin(high) cells isolated from ultraviolet-induced squamous cell carcinoma could propagate effectively by displaying greater tumour initiating and self-renewal abilities. Our study suggests that CD34(high)α6-integrin(high) cells act as initiators upon ultraviolet-induced skin squamous cell carcinoma. Ivyspring International Publisher 2020-09-30 /pmc/articles/PMC7592010/ /pubmed/33123267 http://dx.doi.org/10.7150/jca.45819 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Ke, Hengning
Yang, YvYing
Lin, Yuan
Liu, Li
Sun, Jianmin
Massoumi, Ramin
High expression of CD34 and α6-integrin contributes to the cancer-initiating cell behaviour in ultraviolet-induced mouse skin squamous cell carcinoma
title High expression of CD34 and α6-integrin contributes to the cancer-initiating cell behaviour in ultraviolet-induced mouse skin squamous cell carcinoma
title_full High expression of CD34 and α6-integrin contributes to the cancer-initiating cell behaviour in ultraviolet-induced mouse skin squamous cell carcinoma
title_fullStr High expression of CD34 and α6-integrin contributes to the cancer-initiating cell behaviour in ultraviolet-induced mouse skin squamous cell carcinoma
title_full_unstemmed High expression of CD34 and α6-integrin contributes to the cancer-initiating cell behaviour in ultraviolet-induced mouse skin squamous cell carcinoma
title_short High expression of CD34 and α6-integrin contributes to the cancer-initiating cell behaviour in ultraviolet-induced mouse skin squamous cell carcinoma
title_sort high expression of cd34 and α6-integrin contributes to the cancer-initiating cell behaviour in ultraviolet-induced mouse skin squamous cell carcinoma
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7592010/
https://www.ncbi.nlm.nih.gov/pubmed/33123267
http://dx.doi.org/10.7150/jca.45819
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