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Estimation of the risk of fibrosis in children with nonalcoholic fatty liver disease
AIM OF THE STUDY: Assessment of liver fibrosis as a predictive factor of liver-related mortality in children with nonalcoholic fatty liver disease (NAFLD) is crucial. This study aims to estimate the risk of fibrosis using noninvasive markers. MATERIAL AND METHODS: The study group of 49 children with...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Termedia Publishing House
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7592087/ https://www.ncbi.nlm.nih.gov/pubmed/33145428 http://dx.doi.org/10.5114/ceh.2020.99515 |
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author | Małecki, Paweł Figlerowicz, Magdalena Kemnitz, Paweł Mazur-Melewska, Katarzyna Służewski, Wojciech Mania, Anna |
author_facet | Małecki, Paweł Figlerowicz, Magdalena Kemnitz, Paweł Mazur-Melewska, Katarzyna Służewski, Wojciech Mania, Anna |
author_sort | Małecki, Paweł |
collection | PubMed |
description | AIM OF THE STUDY: Assessment of liver fibrosis as a predictive factor of liver-related mortality in children with nonalcoholic fatty liver disease (NAFLD) is crucial. This study aims to estimate the risk of fibrosis using noninvasive markers. MATERIAL AND METHODS: The study group of 49 children with NAFLD (age range 3-16, mean 10.51 ±3.18 years) was created. The diagnosis was based on clinical picture, abdominal ultrasound, and laboratory tests; four children underwent liver biopsy. Then homeostatic model assessment (HOMA-IR) and noninvasive hepatic fibrosis scores were calculated, and patients were divided into four groups depending on body mass index (BMI, obese vs. lean) and aminotransferases. RESULTS: 71.43% of patients were obese, and 14.29% were overweight. We found that overweight children had lower mean corpuscular volume (MCV) than lean patients. In a group of patients with a high risk of fibrosis or significant fibrosis due to pediatric NAFLD fibrosis score (PNFS), higher alanine aminotransferase (ALT) to platelet ratio (APRI) values were observed. The highest values of APRI were found in a group of lean patients with elevated aminotransferases and the highest value of PNFS – among obese patients with elevated aminotransferases. A strong significant correlation between APRI and PNFS was found (r = 0.88). CONCLUSIONS: Apart from aminotransferase activity, complete blood count should be assessed looking for lower MCV caused by iron deficiency. In contrast to FIB-4 (fibrosis score), PNFS and APRI proved to be more accurate in our group. PNFS seems to be appropriate to evaluate fibrosis in a noninvasive diagnostic algorithm. |
format | Online Article Text |
id | pubmed-7592087 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Termedia Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-75920872020-11-02 Estimation of the risk of fibrosis in children with nonalcoholic fatty liver disease Małecki, Paweł Figlerowicz, Magdalena Kemnitz, Paweł Mazur-Melewska, Katarzyna Służewski, Wojciech Mania, Anna Clin Exp Hepatol Original Paper AIM OF THE STUDY: Assessment of liver fibrosis as a predictive factor of liver-related mortality in children with nonalcoholic fatty liver disease (NAFLD) is crucial. This study aims to estimate the risk of fibrosis using noninvasive markers. MATERIAL AND METHODS: The study group of 49 children with NAFLD (age range 3-16, mean 10.51 ±3.18 years) was created. The diagnosis was based on clinical picture, abdominal ultrasound, and laboratory tests; four children underwent liver biopsy. Then homeostatic model assessment (HOMA-IR) and noninvasive hepatic fibrosis scores were calculated, and patients were divided into four groups depending on body mass index (BMI, obese vs. lean) and aminotransferases. RESULTS: 71.43% of patients were obese, and 14.29% were overweight. We found that overweight children had lower mean corpuscular volume (MCV) than lean patients. In a group of patients with a high risk of fibrosis or significant fibrosis due to pediatric NAFLD fibrosis score (PNFS), higher alanine aminotransferase (ALT) to platelet ratio (APRI) values were observed. The highest values of APRI were found in a group of lean patients with elevated aminotransferases and the highest value of PNFS – among obese patients with elevated aminotransferases. A strong significant correlation between APRI and PNFS was found (r = 0.88). CONCLUSIONS: Apart from aminotransferase activity, complete blood count should be assessed looking for lower MCV caused by iron deficiency. In contrast to FIB-4 (fibrosis score), PNFS and APRI proved to be more accurate in our group. PNFS seems to be appropriate to evaluate fibrosis in a noninvasive diagnostic algorithm. Termedia Publishing House 2020-09-30 2020-09 /pmc/articles/PMC7592087/ /pubmed/33145428 http://dx.doi.org/10.5114/ceh.2020.99515 Text en Copyright © 2020 Clinical and Experimental Hepatology http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0). License (http://creativecommons.org/licenses/by-nc-sa/4.0/) |
spellingShingle | Original Paper Małecki, Paweł Figlerowicz, Magdalena Kemnitz, Paweł Mazur-Melewska, Katarzyna Służewski, Wojciech Mania, Anna Estimation of the risk of fibrosis in children with nonalcoholic fatty liver disease |
title | Estimation of the risk of fibrosis in children with nonalcoholic fatty liver disease |
title_full | Estimation of the risk of fibrosis in children with nonalcoholic fatty liver disease |
title_fullStr | Estimation of the risk of fibrosis in children with nonalcoholic fatty liver disease |
title_full_unstemmed | Estimation of the risk of fibrosis in children with nonalcoholic fatty liver disease |
title_short | Estimation of the risk of fibrosis in children with nonalcoholic fatty liver disease |
title_sort | estimation of the risk of fibrosis in children with nonalcoholic fatty liver disease |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7592087/ https://www.ncbi.nlm.nih.gov/pubmed/33145428 http://dx.doi.org/10.5114/ceh.2020.99515 |
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