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PRosettaC: Rosetta Based Modeling of PROTAC Mediated Ternary Complexes
[Image: see text] Proteolysis-targeting chimeras (PROTACs), which induce degradation by recruitment of an E3 ligase to a target protein, are gaining much interest as a new pharmacological modality. However, designing PROTACs is challenging. Formation of a ternary complex between the protein target,...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7592117/ https://www.ncbi.nlm.nih.gov/pubmed/32976709 http://dx.doi.org/10.1021/acs.jcim.0c00589 |