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Overview of the possible role of vitamin C in management of COVID-19
The mainstay of management of coronavirus disease 2019 (COVID-19) is mainly supportive as to date there is no effective antiviral treatment, apart from remdesivir which has been approved by Food and Drug administration (FDA) for treatment of COVID-19, or vaccine. Supplementation with micronutrients,...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7592143/ https://www.ncbi.nlm.nih.gov/pubmed/33113146 http://dx.doi.org/10.1007/s43440-020-00176-1 |
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author | Abobaker, Anis Alzwi, Aboubaker Alraied, Alsalheen Hamed A. |
author_facet | Abobaker, Anis Alzwi, Aboubaker Alraied, Alsalheen Hamed A. |
author_sort | Abobaker, Anis |
collection | PubMed |
description | The mainstay of management of coronavirus disease 2019 (COVID-19) is mainly supportive as to date there is no effective antiviral treatment, apart from remdesivir which has been approved by Food and Drug administration (FDA) for treatment of COVID-19, or vaccine. Supplementation with micronutrients, such as vitamins and minerals, has gained an increasing interest as part of the supportive management of COVID-19. Vitamin C levels in serum and leukocytes are depleted during the acute stage of infection owing to increased metabolic demands. High-dose vitamin C supplement helps to normalise both serum and leukocytes vitamin C levels. Vitamin C has multiple pharmacological characteristics, antiviral, anti-oxidant, anti-inflammatory and immunomodulatory effects, which make it a potential therapeutic option in management of COVID-19. The use of high dose of intravenous vitamin C for management of COVID-19 in China and the United Stated has shown promising results. There were no reported adverse reactions with the short-term use of high dose of vitamin C. Given the fact that vitamin C is cheap, available and safe drug with beneficial effects in management of viral infections and critically ill patients reported in previous clinical trials, it is sensible to add it to COVID-19 management protocol particularly if the current ongoing clinical trials testing the effect of vitamin C in management of COVID-19 show positive results. |
format | Online Article Text |
id | pubmed-7592143 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-75921432020-10-28 Overview of the possible role of vitamin C in management of COVID-19 Abobaker, Anis Alzwi, Aboubaker Alraied, Alsalheen Hamed A. Pharmacol Rep Review The mainstay of management of coronavirus disease 2019 (COVID-19) is mainly supportive as to date there is no effective antiviral treatment, apart from remdesivir which has been approved by Food and Drug administration (FDA) for treatment of COVID-19, or vaccine. Supplementation with micronutrients, such as vitamins and minerals, has gained an increasing interest as part of the supportive management of COVID-19. Vitamin C levels in serum and leukocytes are depleted during the acute stage of infection owing to increased metabolic demands. High-dose vitamin C supplement helps to normalise both serum and leukocytes vitamin C levels. Vitamin C has multiple pharmacological characteristics, antiviral, anti-oxidant, anti-inflammatory and immunomodulatory effects, which make it a potential therapeutic option in management of COVID-19. The use of high dose of intravenous vitamin C for management of COVID-19 in China and the United Stated has shown promising results. There were no reported adverse reactions with the short-term use of high dose of vitamin C. Given the fact that vitamin C is cheap, available and safe drug with beneficial effects in management of viral infections and critically ill patients reported in previous clinical trials, it is sensible to add it to COVID-19 management protocol particularly if the current ongoing clinical trials testing the effect of vitamin C in management of COVID-19 show positive results. Springer International Publishing 2020-10-28 2020 /pmc/articles/PMC7592143/ /pubmed/33113146 http://dx.doi.org/10.1007/s43440-020-00176-1 Text en © Maj Institute of Pharmacology Polish Academy of Sciences 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Review Abobaker, Anis Alzwi, Aboubaker Alraied, Alsalheen Hamed A. Overview of the possible role of vitamin C in management of COVID-19 |
title | Overview of the possible role of vitamin C in management of COVID-19 |
title_full | Overview of the possible role of vitamin C in management of COVID-19 |
title_fullStr | Overview of the possible role of vitamin C in management of COVID-19 |
title_full_unstemmed | Overview of the possible role of vitamin C in management of COVID-19 |
title_short | Overview of the possible role of vitamin C in management of COVID-19 |
title_sort | overview of the possible role of vitamin c in management of covid-19 |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7592143/ https://www.ncbi.nlm.nih.gov/pubmed/33113146 http://dx.doi.org/10.1007/s43440-020-00176-1 |
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