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Overview of the possible role of vitamin C in management of COVID-19

The mainstay of management of coronavirus disease 2019 (COVID-19) is mainly supportive as to date there is no effective antiviral treatment, apart from remdesivir which has been approved by Food and Drug administration (FDA) for treatment of COVID-19, or vaccine. Supplementation with micronutrients,...

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Autores principales: Abobaker, Anis, Alzwi, Aboubaker, Alraied, Alsalheen Hamed A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7592143/
https://www.ncbi.nlm.nih.gov/pubmed/33113146
http://dx.doi.org/10.1007/s43440-020-00176-1
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author Abobaker, Anis
Alzwi, Aboubaker
Alraied, Alsalheen Hamed A.
author_facet Abobaker, Anis
Alzwi, Aboubaker
Alraied, Alsalheen Hamed A.
author_sort Abobaker, Anis
collection PubMed
description The mainstay of management of coronavirus disease 2019 (COVID-19) is mainly supportive as to date there is no effective antiviral treatment, apart from remdesivir which has been approved by Food and Drug administration (FDA) for treatment of COVID-19, or vaccine. Supplementation with micronutrients, such as vitamins and minerals, has gained an increasing interest as part of the supportive management of COVID-19. Vitamin C levels in serum and leukocytes are depleted during the acute stage of infection owing to increased metabolic demands. High-dose vitamin C supplement helps to normalise both serum and leukocytes vitamin C levels. Vitamin C has multiple pharmacological characteristics, antiviral, anti-oxidant, anti-inflammatory and immunomodulatory effects, which make it a potential therapeutic option in management of COVID-19. The use of high dose of intravenous vitamin C for management of COVID-19 in China and the United Stated has shown promising results. There were no reported adverse reactions with the short-term use of high dose of vitamin C. Given the fact that vitamin C is cheap, available and safe drug with beneficial effects in management of viral infections and critically ill patients reported in previous clinical trials, it is sensible to add it to COVID-19 management protocol particularly if the current ongoing clinical trials testing the effect of vitamin C in management of COVID-19 show positive results.
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spelling pubmed-75921432020-10-28 Overview of the possible role of vitamin C in management of COVID-19 Abobaker, Anis Alzwi, Aboubaker Alraied, Alsalheen Hamed A. Pharmacol Rep Review The mainstay of management of coronavirus disease 2019 (COVID-19) is mainly supportive as to date there is no effective antiviral treatment, apart from remdesivir which has been approved by Food and Drug administration (FDA) for treatment of COVID-19, or vaccine. Supplementation with micronutrients, such as vitamins and minerals, has gained an increasing interest as part of the supportive management of COVID-19. Vitamin C levels in serum and leukocytes are depleted during the acute stage of infection owing to increased metabolic demands. High-dose vitamin C supplement helps to normalise both serum and leukocytes vitamin C levels. Vitamin C has multiple pharmacological characteristics, antiviral, anti-oxidant, anti-inflammatory and immunomodulatory effects, which make it a potential therapeutic option in management of COVID-19. The use of high dose of intravenous vitamin C for management of COVID-19 in China and the United Stated has shown promising results. There were no reported adverse reactions with the short-term use of high dose of vitamin C. Given the fact that vitamin C is cheap, available and safe drug with beneficial effects in management of viral infections and critically ill patients reported in previous clinical trials, it is sensible to add it to COVID-19 management protocol particularly if the current ongoing clinical trials testing the effect of vitamin C in management of COVID-19 show positive results. Springer International Publishing 2020-10-28 2020 /pmc/articles/PMC7592143/ /pubmed/33113146 http://dx.doi.org/10.1007/s43440-020-00176-1 Text en © Maj Institute of Pharmacology Polish Academy of Sciences 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Review
Abobaker, Anis
Alzwi, Aboubaker
Alraied, Alsalheen Hamed A.
Overview of the possible role of vitamin C in management of COVID-19
title Overview of the possible role of vitamin C in management of COVID-19
title_full Overview of the possible role of vitamin C in management of COVID-19
title_fullStr Overview of the possible role of vitamin C in management of COVID-19
title_full_unstemmed Overview of the possible role of vitamin C in management of COVID-19
title_short Overview of the possible role of vitamin C in management of COVID-19
title_sort overview of the possible role of vitamin c in management of covid-19
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7592143/
https://www.ncbi.nlm.nih.gov/pubmed/33113146
http://dx.doi.org/10.1007/s43440-020-00176-1
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