Recent Clinical Developments of Nanomediated Drug Delivery Systems of Taxanes for the Treatment of Cancer

Conventional taxanes are used as cornerstone of the chemotherapeutical treatment for a variety of malignancies. Nevertheless, a large proportion of patients do not benefit from their treatment while they do suffer from severe adverse events related to the solvent or to the active compound. Cremophor...

Descripción completa

Detalles Bibliográficos
Autores principales: van Eerden, Ruben A G, Mathijssen, Ron H J, Koolen, Stijn L W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7592152/
https://www.ncbi.nlm.nih.gov/pubmed/33132699
http://dx.doi.org/10.2147/IJN.S272529
_version_ 1783601136922525696
author van Eerden, Ruben A G
Mathijssen, Ron H J
Koolen, Stijn L W
author_facet van Eerden, Ruben A G
Mathijssen, Ron H J
Koolen, Stijn L W
author_sort van Eerden, Ruben A G
collection PubMed
description Conventional taxanes are used as cornerstone of the chemotherapeutical treatment for a variety of malignancies. Nevertheless, a large proportion of patients do not benefit from their treatment while they do suffer from severe adverse events related to the solvent or to the active compound. Cremophor EL and polysorbate 80 free formulations, conjugates, oral formulations and different types of drug delivery systems are some examples of the several attempts to improve the treatment with taxanes. In this review article, we discuss recent clinical developments of nanomediated drug delivery systems of taxanes for the treatment of cancer. Targeting mechanisms of drug delivery systems and characteristics of the most commonly used taxane-containing drug delivery systems in the clinical setting will be discussed in this review.
format Online
Article
Text
id pubmed-7592152
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Dove
record_format MEDLINE/PubMed
spelling pubmed-75921522020-10-29 Recent Clinical Developments of Nanomediated Drug Delivery Systems of Taxanes for the Treatment of Cancer van Eerden, Ruben A G Mathijssen, Ron H J Koolen, Stijn L W Int J Nanomedicine Review Conventional taxanes are used as cornerstone of the chemotherapeutical treatment for a variety of malignancies. Nevertheless, a large proportion of patients do not benefit from their treatment while they do suffer from severe adverse events related to the solvent or to the active compound. Cremophor EL and polysorbate 80 free formulations, conjugates, oral formulations and different types of drug delivery systems are some examples of the several attempts to improve the treatment with taxanes. In this review article, we discuss recent clinical developments of nanomediated drug delivery systems of taxanes for the treatment of cancer. Targeting mechanisms of drug delivery systems and characteristics of the most commonly used taxane-containing drug delivery systems in the clinical setting will be discussed in this review. Dove 2020-10-22 /pmc/articles/PMC7592152/ /pubmed/33132699 http://dx.doi.org/10.2147/IJN.S272529 Text en © 2020 van Eerden et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
van Eerden, Ruben A G
Mathijssen, Ron H J
Koolen, Stijn L W
Recent Clinical Developments of Nanomediated Drug Delivery Systems of Taxanes for the Treatment of Cancer
title Recent Clinical Developments of Nanomediated Drug Delivery Systems of Taxanes for the Treatment of Cancer
title_full Recent Clinical Developments of Nanomediated Drug Delivery Systems of Taxanes for the Treatment of Cancer
title_fullStr Recent Clinical Developments of Nanomediated Drug Delivery Systems of Taxanes for the Treatment of Cancer
title_full_unstemmed Recent Clinical Developments of Nanomediated Drug Delivery Systems of Taxanes for the Treatment of Cancer
title_short Recent Clinical Developments of Nanomediated Drug Delivery Systems of Taxanes for the Treatment of Cancer
title_sort recent clinical developments of nanomediated drug delivery systems of taxanes for the treatment of cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7592152/
https://www.ncbi.nlm.nih.gov/pubmed/33132699
http://dx.doi.org/10.2147/IJN.S272529
work_keys_str_mv AT vaneerdenrubenag recentclinicaldevelopmentsofnanomediateddrugdeliverysystemsoftaxanesforthetreatmentofcancer
AT mathijssenronhj recentclinicaldevelopmentsofnanomediateddrugdeliverysystemsoftaxanesforthetreatmentofcancer
AT koolenstijnlw recentclinicaldevelopmentsofnanomediateddrugdeliverysystemsoftaxanesforthetreatmentofcancer

Ejemplares similares