Long Noncoding RNA HOXB-AS1 Is Upregulated in Endometrial Carcinoma and Sponged miR-149-3p to Upregulate Wnt10b

The functions of Long noncoding RNA (lncRNA) HOXB-AS1 have been investigated in glioblastoma and multiple myeloma. However, the role of lncRNA HOXB-AS1 in endometrial carcinoma (EC) remains largely unknown. This study investigated the underlying mechanisms of the lncRNA HOXB-AS1 on the progression o...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Da, Qiu, Min, Jiang, Lili, Liu, Kuiran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7592328/
https://www.ncbi.nlm.nih.gov/pubmed/33073693
http://dx.doi.org/10.1177/1533033820967462
_version_ 1783601164129927168
author Liu, Da
Qiu, Min
Jiang, Lili
Liu, Kuiran
author_facet Liu, Da
Qiu, Min
Jiang, Lili
Liu, Kuiran
author_sort Liu, Da
collection PubMed
description The functions of Long noncoding RNA (lncRNA) HOXB-AS1 have been investigated in glioblastoma and multiple myeloma. However, the role of lncRNA HOXB-AS1 in endometrial carcinoma (EC) remains largely unknown. This study investigated the underlying mechanisms of the lncRNA HOXB-AS1 on the progression of EC. In this study, We found that HOXB-AS1 expression was significantly upregulated in EC tissue samples and was associated with shorter survival time. Furthermore, upregulation of HOXB-AS1 promoted proliferation, invasion, and migration of EC cell. HOXB-AS1 and Wnt10b directly bound to miR-149-3p. HOXB-AS1 increased the expression of Wnt10b by binding to miR-149-3p. We further verified the upregulation of β-catenin, cyclin D1, and c-myc induced by HOXB-AS1. In conclusion, our results indicated that HOXB-AS1 exerted oncogenic function as competing endogenous RNA (ceRNA) of miR-149-3p to release Wnt10b and activated Wnt/β-catenin pathway.
format Online
Article
Text
id pubmed-7592328
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher SAGE Publications
record_format MEDLINE/PubMed
spelling pubmed-75923282020-11-10 Long Noncoding RNA HOXB-AS1 Is Upregulated in Endometrial Carcinoma and Sponged miR-149-3p to Upregulate Wnt10b Liu, Da Qiu, Min Jiang, Lili Liu, Kuiran Technol Cancer Res Treat Original Article The functions of Long noncoding RNA (lncRNA) HOXB-AS1 have been investigated in glioblastoma and multiple myeloma. However, the role of lncRNA HOXB-AS1 in endometrial carcinoma (EC) remains largely unknown. This study investigated the underlying mechanisms of the lncRNA HOXB-AS1 on the progression of EC. In this study, We found that HOXB-AS1 expression was significantly upregulated in EC tissue samples and was associated with shorter survival time. Furthermore, upregulation of HOXB-AS1 promoted proliferation, invasion, and migration of EC cell. HOXB-AS1 and Wnt10b directly bound to miR-149-3p. HOXB-AS1 increased the expression of Wnt10b by binding to miR-149-3p. We further verified the upregulation of β-catenin, cyclin D1, and c-myc induced by HOXB-AS1. In conclusion, our results indicated that HOXB-AS1 exerted oncogenic function as competing endogenous RNA (ceRNA) of miR-149-3p to release Wnt10b and activated Wnt/β-catenin pathway. SAGE Publications 2020-10-19 /pmc/articles/PMC7592328/ /pubmed/33073693 http://dx.doi.org/10.1177/1533033820967462 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Article
Liu, Da
Qiu, Min
Jiang, Lili
Liu, Kuiran
Long Noncoding RNA HOXB-AS1 Is Upregulated in Endometrial Carcinoma and Sponged miR-149-3p to Upregulate Wnt10b
title Long Noncoding RNA HOXB-AS1 Is Upregulated in Endometrial Carcinoma and Sponged miR-149-3p to Upregulate Wnt10b
title_full Long Noncoding RNA HOXB-AS1 Is Upregulated in Endometrial Carcinoma and Sponged miR-149-3p to Upregulate Wnt10b
title_fullStr Long Noncoding RNA HOXB-AS1 Is Upregulated in Endometrial Carcinoma and Sponged miR-149-3p to Upregulate Wnt10b
title_full_unstemmed Long Noncoding RNA HOXB-AS1 Is Upregulated in Endometrial Carcinoma and Sponged miR-149-3p to Upregulate Wnt10b
title_short Long Noncoding RNA HOXB-AS1 Is Upregulated in Endometrial Carcinoma and Sponged miR-149-3p to Upregulate Wnt10b
title_sort long noncoding rna hoxb-as1 is upregulated in endometrial carcinoma and sponged mir-149-3p to upregulate wnt10b
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7592328/
https://www.ncbi.nlm.nih.gov/pubmed/33073693
http://dx.doi.org/10.1177/1533033820967462
work_keys_str_mv AT liuda longnoncodingrnahoxbas1isupregulatedinendometrialcarcinomaandspongedmir1493ptoupregulatewnt10b
AT qiumin longnoncodingrnahoxbas1isupregulatedinendometrialcarcinomaandspongedmir1493ptoupregulatewnt10b
AT jianglili longnoncodingrnahoxbas1isupregulatedinendometrialcarcinomaandspongedmir1493ptoupregulatewnt10b
AT liukuiran longnoncodingrnahoxbas1isupregulatedinendometrialcarcinomaandspongedmir1493ptoupregulatewnt10b

Ejemplares similares