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Design and synthesis of multi-target directed 1,2,3-triazole-dimethylaminoacryloyl-chromenone derivatives with potential use in Alzheimer's disease
To discover multifunctional agents for the treatment of Alzheimer's disease (AD), a new series of 1,2,3-triazole-chromenone derivatives were designed and synthesized based on the multi target-directed ligands approach. The in vitro biological activities included acetylcholinesterase (AChE) and...
Autores principales: | Karimi Askarani, Hajar, Iraji, Aida, Rastegari, Arezoo, Abbas Bukhari, Syed Nasir, Firuzi, Omidreza, Akbarzadeh, Tahmineh, Saeedi, Mina |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7592376/ https://www.ncbi.nlm.nih.gov/pubmed/33134975 http://dx.doi.org/10.1186/s13065-020-00715-0 |
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