Cargando…
Distinct Roles of IL-1β and IL-18 in NLRC4-Induced Autoinflammation
The NLRC4 inflammasome assembles in response to detection of bacterial invasion, and NLRC4 activation leads to the production of IL-1β and IL-18 together with pyroptosis-mediated cell death. Missense activating mutations in NLRC4 cause autoinflammatory disorders whose symptoms are distinctly depende...
| Autores principales: | , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2020
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7592392/ https://www.ncbi.nlm.nih.gov/pubmed/33178225 http://dx.doi.org/10.3389/fimmu.2020.591713 |