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Quantification of brain oxygen extraction and metabolism with [(15)O]-gas PET: A technical review in the era of PET/MRI

Oxygen extraction fraction (OEF) and the cerebral metabolic rate of oxygen (CMRO(2)) are key cerebral physiological parameters to identify at-risk cerebrovascular patients and understand brain health and function. PET imaging with [(15)O]-oxygen tracers, either through continuous or bolus inhalation...

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Autores principales: Fan, Audrey P., An, Hongyu, Moradi, Farshad, Rosenberg, Jarrett, Ishii, Yosuke, Nariai, Tadashi, Okazawa, Hidehiko, Zaharchuk, Greg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7592419/
https://www.ncbi.nlm.nih.gov/pubmed/32634594
http://dx.doi.org/10.1016/j.neuroimage.2020.117136
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author Fan, Audrey P.
An, Hongyu
Moradi, Farshad
Rosenberg, Jarrett
Ishii, Yosuke
Nariai, Tadashi
Okazawa, Hidehiko
Zaharchuk, Greg
author_facet Fan, Audrey P.
An, Hongyu
Moradi, Farshad
Rosenberg, Jarrett
Ishii, Yosuke
Nariai, Tadashi
Okazawa, Hidehiko
Zaharchuk, Greg
author_sort Fan, Audrey P.
collection PubMed
description Oxygen extraction fraction (OEF) and the cerebral metabolic rate of oxygen (CMRO(2)) are key cerebral physiological parameters to identify at-risk cerebrovascular patients and understand brain health and function. PET imaging with [(15)O]-oxygen tracers, either through continuous or bolus inhalation, provides non-invasive assessment of OEF and CMRO(2). Numerous tracer delivery, PET acquisition, and kinetic modeling approaches have been adopted to map brain oxygenation. The purpose of this technical review is to critically evaluate different methods for [(15)O]-gas PET and its impact on the accuracy and reproducibility of OEF and CMRO(2) measurements. We perform a meta-analysis of brain oxygenation PET studies in healthy volunteers and compare between continuous and bolus inhalation techniques. We also describe OEF metrics that have been used to detect hemodynamic impairment in cerebrovascular disease. For these patients, advanced techniques to accelerate the PET scans and potential synthesis with MRI to avoid arterial blood sampling would facilitate broader use of [(15)O]-oxygen PET for brain physiological assessment.
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spelling pubmed-75924192020-10-28 Quantification of brain oxygen extraction and metabolism with [(15)O]-gas PET: A technical review in the era of PET/MRI Fan, Audrey P. An, Hongyu Moradi, Farshad Rosenberg, Jarrett Ishii, Yosuke Nariai, Tadashi Okazawa, Hidehiko Zaharchuk, Greg Neuroimage Article Oxygen extraction fraction (OEF) and the cerebral metabolic rate of oxygen (CMRO(2)) are key cerebral physiological parameters to identify at-risk cerebrovascular patients and understand brain health and function. PET imaging with [(15)O]-oxygen tracers, either through continuous or bolus inhalation, provides non-invasive assessment of OEF and CMRO(2). Numerous tracer delivery, PET acquisition, and kinetic modeling approaches have been adopted to map brain oxygenation. The purpose of this technical review is to critically evaluate different methods for [(15)O]-gas PET and its impact on the accuracy and reproducibility of OEF and CMRO(2) measurements. We perform a meta-analysis of brain oxygenation PET studies in healthy volunteers and compare between continuous and bolus inhalation techniques. We also describe OEF metrics that have been used to detect hemodynamic impairment in cerebrovascular disease. For these patients, advanced techniques to accelerate the PET scans and potential synthesis with MRI to avoid arterial blood sampling would facilitate broader use of [(15)O]-oxygen PET for brain physiological assessment. 2020-07-04 2020-10-15 /pmc/articles/PMC7592419/ /pubmed/32634594 http://dx.doi.org/10.1016/j.neuroimage.2020.117136 Text en This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Fan, Audrey P.
An, Hongyu
Moradi, Farshad
Rosenberg, Jarrett
Ishii, Yosuke
Nariai, Tadashi
Okazawa, Hidehiko
Zaharchuk, Greg
Quantification of brain oxygen extraction and metabolism with [(15)O]-gas PET: A technical review in the era of PET/MRI
title Quantification of brain oxygen extraction and metabolism with [(15)O]-gas PET: A technical review in the era of PET/MRI
title_full Quantification of brain oxygen extraction and metabolism with [(15)O]-gas PET: A technical review in the era of PET/MRI
title_fullStr Quantification of brain oxygen extraction and metabolism with [(15)O]-gas PET: A technical review in the era of PET/MRI
title_full_unstemmed Quantification of brain oxygen extraction and metabolism with [(15)O]-gas PET: A technical review in the era of PET/MRI
title_short Quantification of brain oxygen extraction and metabolism with [(15)O]-gas PET: A technical review in the era of PET/MRI
title_sort quantification of brain oxygen extraction and metabolism with [(15)o]-gas pet: a technical review in the era of pet/mri
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7592419/
https://www.ncbi.nlm.nih.gov/pubmed/32634594
http://dx.doi.org/10.1016/j.neuroimage.2020.117136
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