Experimental glioma with high bHLH expression harbor increased replicative stress and are sensitive toward ATR inhibition

BACKGROUND: The overexpression of (basic)helix-loop-helix ((b)HLH) transcription factors (TFs) is frequent in malignant glioma. We investigated molecular effects upon disruption of the (b)HLH network by a dominant-negative variant of the E47 protein (dnE47). Our goal was to identify novel molecular...

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Detalles Bibliográficos
Autores principales: Koch, Marilin Sophia, Czemmel, Stefan, Lennartz, Felix, Beyeler, Sarah, Rajaraman, Srinath, Przystal, Justyna Magdalena, Govindarajan, Parameswari, Canjuga, Denis, Neumann, Manfred, Rizzu, Patrizia, Zwirner, Stefan, Hoetker, Michael Stefan, Zender, Lars, Walter, Bianca, Tatagiba, Marcos, Raineteau, Olivier, Heutink, Peter, Nahnsen, Sven, Tabatabai, Ghazaleh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Basic and Translational Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7592426/
https://www.ncbi.nlm.nih.gov/pubmed/33134924
http://dx.doi.org/10.1093/noajnl/vdaa115

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