CD14 genotype and functional dichotomy of CD14+ and CD14- cells are associated with activated immune response and development of Chagas dilated cardiomyopathy

We aimed to investigate the association of CD14 -260C/T (rs2569190) polymorphism and Chagas cardiomyopathy and the functional characteristics of CD14+ and CD14- monocytes upon infection with Trypanosoma cruzi. We observed an association between the T- genotype (absence of allele -260T) related to lo...

Descripción completa

Detalles Bibliográficos
Autores principales: Costa, Germano Carneiro, Rocha, Manoel Otávio da Costa, de Souza, Paulo Eduardo Alencar, Melo, Diego Felipe SA, Moreira, Paula Rocha, Gollob, Kenneth John, Nunes, Maria do Carmo Pereira, Dutra, Walderez Ornelas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Instituto Oswaldo Cruz, Ministério da Saúde 2020
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7592494/
https://www.ncbi.nlm.nih.gov/pubmed/33146244
http://dx.doi.org/10.1590/0074-02760200110
_version_ 1783601197668630528
author Costa, Germano Carneiro
Rocha, Manoel Otávio da Costa
de Souza, Paulo Eduardo Alencar
Melo, Diego Felipe SA
Moreira, Paula Rocha
Gollob, Kenneth John
Nunes, Maria do Carmo Pereira
Dutra, Walderez Ornelas
author_facet Costa, Germano Carneiro
Rocha, Manoel Otávio da Costa
de Souza, Paulo Eduardo Alencar
Melo, Diego Felipe SA
Moreira, Paula Rocha
Gollob, Kenneth John
Nunes, Maria do Carmo Pereira
Dutra, Walderez Ornelas
author_sort Costa, Germano Carneiro
collection PubMed
description We aimed to investigate the association of CD14 -260C/T (rs2569190) polymorphism and Chagas cardiomyopathy and the functional characteristics of CD14+ and CD14- monocytes upon infection with Trypanosoma cruzi. We observed an association between the T- genotype (absence of allele -260T) related to low CD14 expression and the dilated cardiomyopathy type of Chagas disease. Furthermore, we observed that CD14- monocytes showed a more activated profile upon in vitro infection with T. cruzi than CD14+ monocytes. Our findings suggest that T- genotype is associated with susceptibility to develop Chagas dilated cardiomyopathy, likely linked to the T. cruzi-induced inflammatory profile of CD14- monocytes.
format Online
Article
Text
id pubmed-7592494
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Instituto Oswaldo Cruz, Ministério da Saúde
record_format MEDLINE/PubMed
spelling pubmed-75924942020-11-10 CD14 genotype and functional dichotomy of CD14+ and CD14- cells are associated with activated immune response and development of Chagas dilated cardiomyopathy Costa, Germano Carneiro Rocha, Manoel Otávio da Costa de Souza, Paulo Eduardo Alencar Melo, Diego Felipe SA Moreira, Paula Rocha Gollob, Kenneth John Nunes, Maria do Carmo Pereira Dutra, Walderez Ornelas Mem Inst Oswaldo Cruz Short Communication We aimed to investigate the association of CD14 -260C/T (rs2569190) polymorphism and Chagas cardiomyopathy and the functional characteristics of CD14+ and CD14- monocytes upon infection with Trypanosoma cruzi. We observed an association between the T- genotype (absence of allele -260T) related to low CD14 expression and the dilated cardiomyopathy type of Chagas disease. Furthermore, we observed that CD14- monocytes showed a more activated profile upon in vitro infection with T. cruzi than CD14+ monocytes. Our findings suggest that T- genotype is associated with susceptibility to develop Chagas dilated cardiomyopathy, likely linked to the T. cruzi-induced inflammatory profile of CD14- monocytes. Instituto Oswaldo Cruz, Ministério da Saúde 2020-10-28 /pmc/articles/PMC7592494/ /pubmed/33146244 http://dx.doi.org/10.1590/0074-02760200110 Text en https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License
spellingShingle Short Communication
Costa, Germano Carneiro
Rocha, Manoel Otávio da Costa
de Souza, Paulo Eduardo Alencar
Melo, Diego Felipe SA
Moreira, Paula Rocha
Gollob, Kenneth John
Nunes, Maria do Carmo Pereira
Dutra, Walderez Ornelas
CD14 genotype and functional dichotomy of CD14+ and CD14- cells are associated with activated immune response and development of Chagas dilated cardiomyopathy
title CD14 genotype and functional dichotomy of CD14+ and CD14- cells are associated with activated immune response and development of Chagas dilated cardiomyopathy
title_full CD14 genotype and functional dichotomy of CD14+ and CD14- cells are associated with activated immune response and development of Chagas dilated cardiomyopathy
title_fullStr CD14 genotype and functional dichotomy of CD14+ and CD14- cells are associated with activated immune response and development of Chagas dilated cardiomyopathy
title_full_unstemmed CD14 genotype and functional dichotomy of CD14+ and CD14- cells are associated with activated immune response and development of Chagas dilated cardiomyopathy
title_short CD14 genotype and functional dichotomy of CD14+ and CD14- cells are associated with activated immune response and development of Chagas dilated cardiomyopathy
title_sort cd14 genotype and functional dichotomy of cd14+ and cd14- cells are associated with activated immune response and development of chagas dilated cardiomyopathy
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7592494/
https://www.ncbi.nlm.nih.gov/pubmed/33146244
http://dx.doi.org/10.1590/0074-02760200110
work_keys_str_mv AT costagermanocarneiro cd14genotypeandfunctionaldichotomyofcd14andcd14cellsareassociatedwithactivatedimmuneresponseanddevelopmentofchagasdilatedcardiomyopathy
AT rochamanoelotaviodacosta cd14genotypeandfunctionaldichotomyofcd14andcd14cellsareassociatedwithactivatedimmuneresponseanddevelopmentofchagasdilatedcardiomyopathy
AT desouzapauloeduardoalencar cd14genotypeandfunctionaldichotomyofcd14andcd14cellsareassociatedwithactivatedimmuneresponseanddevelopmentofchagasdilatedcardiomyopathy
AT melodiegofelipesa cd14genotypeandfunctionaldichotomyofcd14andcd14cellsareassociatedwithactivatedimmuneresponseanddevelopmentofchagasdilatedcardiomyopathy
AT moreirapaularocha cd14genotypeandfunctionaldichotomyofcd14andcd14cellsareassociatedwithactivatedimmuneresponseanddevelopmentofchagasdilatedcardiomyopathy
AT gollobkennethjohn cd14genotypeandfunctionaldichotomyofcd14andcd14cellsareassociatedwithactivatedimmuneresponseanddevelopmentofchagasdilatedcardiomyopathy
AT nunesmariadocarmopereira cd14genotypeandfunctionaldichotomyofcd14andcd14cellsareassociatedwithactivatedimmuneresponseanddevelopmentofchagasdilatedcardiomyopathy
AT dutrawalderezornelas cd14genotypeandfunctionaldichotomyofcd14andcd14cellsareassociatedwithactivatedimmuneresponseanddevelopmentofchagasdilatedcardiomyopathy

Ejemplares similares